Who is the manufacturer of Cetuximab?
Cetuximab is manufactured and marketed by Merck Limited.
Is Cetuximab approved by USA FDA?
Yes, Cetuximab is approved by FDA. The product was approved in 2014.
What are the storage conditions of Cetuximab?
The product should be Stored at 2° to 8°C. Cetuximab vials should be protected from light. Do not freeze or shake.
How Cetuximab is supplied?
Cetuximab is supplied as Single Vial for Injection of 100mg and 500mg as single vial for injection.
How does Cetuximab work?
The epidermal growth factor receptor (EGFR, HER1, c-ErbB-1) is a transmembrane glycoprotein that is a member of a subfamily of type I receptor tyrosine kinases including EGFR, HER2, HER3, and HER4. The EGFR is constitutively expressed in many normal epithelial tissues, including the skin and hair follicle. Expression of EGFR is also detected in many human cancers including those of the head and neck, colon, and rectum. Cetuximab binds specifically to the EGFR on both normal and tumor cells, and competitively inhibits the binding of epidermal growth factor (EGF) and other ligands, such as transforming growth factor-alpha. In vitro assays and in vivo animal studies have shown that binding of cetuximab to the EGFR blocks phosphorylation and activation of receptor-associated kinases, resulting in inhibition of cell growth, induction of apoptosis, and decreased matrix metalloproteinase and vascular endothelial growth factor production. Signal transduction through the EGFR results in activation of wild-type KRAS protein. However, in cells with activating KRAS somatic mutations, the mutant KRAS protein is continuously active and appears independent of EGFR regulation.
What is Cetuximab used for?
Squamous Cell Carcinoma of the Head and Neck (SCCHN)
Cetuximab® is indicated in combination with radiation therapy for the initial treatment of locally or regionally advanced squamous cell carcinoma of the head and neck.
Cetuximab, as a single agent, is indicated for the treatment of epidermal growth factor receptor (EGFR)-expressing metastatic colorectal cancer after failure of both irinotecan and oxaliplatin-based regimens.
How many brands of Cetuximab are available in India?
Cetuximab is an innovator medicine. There are no other brands available for Cetuximab.
Is there any generic or bio similar available for Cetuximab.
There are no generic or biosimilar available for Cetuximab.
What is the price of Cetuximab in India?
You can call or WhatsApp (+91) 9650877511 or send mail to firstname.lastname@example.org to know the price.
Other information about Cetuximab
The European Court of Justice has determined that Roche’s Cetuximab may be reimbursed for ARMD- despite Novartis and Bayer’s challenge.
Is it safe to buy Cetuximab in India from local distributor?
It is always better to check the credential of the person / distributor before confirming.
As per the legal guidelines, only patients can import the product after getting proper Documentation.