Generic name of Geftinat is Geftinib
Geftinat is manufactured by Natco Pharma Limited, India.
Yes, Geftinat (Geftinib) Is Approved By FDA. The Product Was Approved In 2003.
Geftinat is available as 250 mg orally once daily with or without food until disease progression or unacceptable toxicity.
The product should be Stored at 20° to 25°C (68° to 77°F). Excursions are permitted between 15°C to 30°C (59°F to 86°F)
Geftinat is supplied as pack of 30 tablets, each tablet of 250mg.
The epidermal growth factor receptor (EGFR) is expressed on the cell surface of both normal and cancer cells and plays a role in the processes of cell growth and proliferation. Some EGFR activating mutations (exon 19 deletion or exon 21 point mutation L858R) within NSCLC cells have been identified as contributing to the promotion of tumor cell growth, blocking of apoptosis, increasing the production of angiogenic factors and facilitating the processes of metastasis. Gefitinib reversibly inhibits the kinase activity of wild-type and certain activating mutations of EGFR, preventing autophosphorylation of tyrosine residues associated with the receptor, thereby inhibiting further downstream signalling and blocking EGFR-dependent proliferation. Gefitinib binding affinity for EGFR exon 19 deletion or exon 21 point mutation L858R mutations is higher than its affinity for the wild-type EGFR. Gefitinib also inhibits IGF and PDGF-mediated signalling at clinically relevant concentrations; inhibition of other tyrosine kinase receptors has not been fully characterized.
Geftinib 250 mg is a tyrosine kinase inhibitor indicated for the first-line treatment of patients with metastatic non-small cell lung cancer (NSCLC) whose tumors have epidermal growth factor receptor (EGFR) exon 19 deletions or exon 21 (L858R) substitution mutations as detected by an FDA-approved test.
Geftinat 250 mg (Geftinib) is a branded , affordable generic brand of Geftinib. There are other generic option available for Geftinib from reputed manufacturers.
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Geftinat 250 mg is a (prescription drug, doctor prescribed medication or health care professional prescribed medicine) pharmaceutical drug that can be legally dispensed against a medical prescription.
Geftinat (Geftinib) 250mg can be made available through the network of authorised distributors in India. (Mumbai, Kolkata, Hyderabad, Chennai, Ahmedabad, Delhi, Bangalore and Pune etc.)
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