{"id":3259,"date":"2023-08-17T06:42:48","date_gmt":"2023-08-17T06:42:48","guid":{"rendered":"https:\/\/indiangenericmedicines.com\/?post_type=product&#038;p=3259"},"modified":"2024-06-06T07:20:55","modified_gmt":"2024-06-06T07:20:55","slug":"buy-dabrafenib-online-in-india","status":"publish","type":"product","link":"https:\/\/indiangenericmedicines.com\/de\/oncology\/buy-dabrafenib-online-in-india\/","title":{"rendered":"Dabrafenib"},"content":{"rendered":"<p style=\"text-align: justify\">Indian Generic Medicines assist you in delivering Dabrafenib capsules across the world as per the customer\u2019s prescribed medication and applicable regulatory approval.<\/p>\n<p style=\"text-align: justify\"><strong>Dabrafenib<\/strong> <span style=\"font-weight: 400\">is a kinase inhibitor used alone for treating patients with unresectable or metastatic melanoma with mutation BRAF V600E and together with medicine trametinib, for:<\/span><\/p>\n<ul style=\"text-align: justify\">\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Treating patients with unresectable or metastatic melanoma with mutations BRAF V600E or V600K.<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">The adjuvant treatment of those with melanoma with mutations BRAF V600E or V600K, and enhancement of lymph node(s), after complete resection.<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Treating patients with metastatic non-small cell lung cancer (mNSCLC) with mutation BRAF V600E.<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Treating patients with locally advanced or metastatic anaplastic thyroid cancer (ATC) with mutation BRAF V600E and with no satisfactory locoregional treatment options.<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Treating adult and pediatric patients aged 1 year and older with unresectable or metastatic solid tumors with mutation BRAF V600E who have progressed after prior therapy and have no satisfactory alternative treatment options.<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Treating pediatric patients aged 1 year and older with low-grade glioma (LGG) with a mutation BRAF V600E who require systemic therapy.<\/span><\/li>\n<\/ul>\n<p style=\"text-align: justify\"><b>Limitations of Use:<\/b> <span style=\"font-weight: 400\">Dabrafenib<\/span><span style=\"font-weight: 400\"> is not for treating patients with colorectal cancer due to known intrinsic resistance to BRAF inhibition. <\/span><span style=\"font-weight: 400\">Dabrafenib<\/span><span style=\"font-weight: 400\"> is not for treating patients with wild-type BRAF solid tumors.<\/span><\/p>\n<p style=\"text-align: justify\"><b>Dosage and Side Effects: <\/b><span style=\"font-weight: 400\">The recommended dosage of Dabrafenib in adult patients is 150 mg (two 75 mg capsules) orally twice daily. The recommended dosage for Dabrafenib in pediatric patients is based on body weight. Take the dosage of Dabrafenib at least 60 minutes before or at least 120 minutes after a meal. There is no established recommended dose for Dabrafenib capsules in patients weighing less than 26 kg.<\/span><\/p>\n<p style=\"text-align: justify\"><span style=\"font-weight: 400\">The most common side effects of Dabrafenib capsules as a single agent are headache, pyrexia, arthralgia, hyperkeratosis, papilloma, alopecia, and palmar-plantar erythrodysesthesia syndrome. The most common side effects of Dabrafenib in combination with trametinib include:\u00a0<\/span><\/p>\n<ul style=\"text-align: justify\">\n<li style=\"font-weight: 400\"><b>Unresectable or metastatic melanoma:<\/b><span style=\"font-weight: 400\"> headache, chills, pyrexia, rash, cough, and arthralgia.<\/span><\/li>\n<li style=\"font-weight: 400\"><b>Adjuvant treatment of melanoma:<\/b><span style=\"font-weight: 400\"> headache, rash, nausea, pyrexia, fatigue, chills, arthralgia, vomiting, diarrhea, and myalgia.<\/span><\/li>\n<li style=\"font-weight: 400\"><b>NSCLC:<\/b><span style=\"font-weight: 400\"> vomiting, diarrhea, nausea, pyrexia, fatigue, dry skin, decreased appetite, rash, cough, edema, chills, dyspnea, and hemorrhage.<\/span><\/li>\n<li style=\"font-weight: 400\"><b>Adult patients with solid tumors:<\/b><span style=\"font-weight: 400\"> chills, headache, pyrexia, fatigue, nausea, rash, hemorrhage, myalgia, arthralgia, cough, vomiting, constipation, diarrhea, and edema.<\/span><\/li>\n<li style=\"font-weight: 400\"><b>Pediatric patients with solid tumors:<\/b><span style=\"font-weight: 400\"> vomiting, fatigue, pyrexia, rash, dry skin, cough, diarrhea, abdominal pain, nausea, dermatitis acneiform, constipation, headache, hemorrhage, and paronychia.<\/span><\/li>\n<li style=\"font-weight: 400\"><b>Pediatric patients with LGG:<\/b><span style=\"font-weight: 400\"> headache, vomiting, pyrexia, rash, musculoskeletal pain, fatigue, diarrhea, dry skin, abdominal pain, nausea, hemorrhage, and dermatitis acneiform.<\/span><\/li>\n<\/ul>\n<p style=\"text-align: justify\"><b>Warning and Precautions:<\/b><\/p>\n<ul>\n<li style=\"font-weight: 400;text-align: justify\"><span style=\"font-weight: 400\">Hemorrhage, including major hemorrhage defined as symptomatic bleeding in a critical area or organ, can occur when Dabrafenib is used with trametinib. Fatal cases may occur. Permanently stop treatment for all Grade 4 hemorrhagic events and for any Grade 3 hemorrhagic events that do not improve. Withhold therapy for Grade 3 hemorrhagic events; if improved, resume at the next lower dose level.<\/span><\/li>\n<li style=\"font-weight: 400;text-align: justify\"><span style=\"font-weight: 400\">Serious febrile reactions and fever of any severity complicated by hypotension, rigors or chills, dehydration, or renal failure, can occur with Dabrafenib. Using Dabrafenib with trametinib increases the likelihood and intensity of fever compared to using Dabrafenib alone.<\/span><\/li>\n<li style=\"font-weight: 400;text-align: justify\"><span style=\"font-weight: 400\">Dabrafenib, when used with trametinib, may lead to severe skin reactions like Stevens-Johnson syndrome and DRESS, which can be life-threatening. Monitor patients for new or worsening serious skin reactions. Permanently discontinue treatment for SCARs.<\/span><\/li>\n<li style=\"font-weight: 400;text-align: justify\"><span style=\"font-weight: 400\">Due to how it works, Dabrafenib might stimulate the growth of cancers that have a mutated or activated RAS gene. Monitor patients receiving this drug for signs or symptoms of non-cutaneous malignancies. Permanently stop therapy for RAS mutation-positive non-cutaneous malignancies.<\/span><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<div class=\"wpb_text_column wpb_content_element\">\n<div class=\"wpb_wrapper\">\n<ul>\n<li><b>Medicine Name-<\/b> <span style=\"font-weight: 400\">Tafinlar<\/span><\/li>\n<li><b>API-<\/b><span style=\"font-weight: 400\"> Dabrafenib<\/span><\/li>\n<li><b>Packaging-<\/b><span style=\"font-weight: 400\"> Capsules<\/span><\/li>\n<li><b>Strength- <\/b><span style=\"font-weight: 400\">50 mg, 75 mg\u00a0<\/span><\/li>\n<li><b>Manufactured by- <\/b><span style=\"font-weight: 400\">Novartis<\/span><\/li>\n<\/ul>\n<\/div>\n<\/div>","protected":false},"featured_media":4737,"template":"","meta":[],"product_brand":[],"product_cat":[18],"product_tag":[719,721,720,718],"class_list":["post-3259","product","type-product","status-publish","has-post-thumbnail","product_cat-oncology","product_tag-buy-dabrafenib-capsules","product_tag-buy-tafinlar-capsules-online","product_tag-cost-of-dabrafenib-capsules","product_tag-dabrafenib-capsules-price","first","instock","shipping-taxable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/indiangenericmedicines.com\/de\/wp-json\/wp\/v2\/product\/3259","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/indiangenericmedicines.com\/de\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/indiangenericmedicines.com\/de\/wp-json\/wp\/v2\/types\/product"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/indiangenericmedicines.com\/de\/wp-json\/wp\/v2\/media\/4737"}],"wp:attachment":[{"href":"https:\/\/indiangenericmedicines.com\/de\/wp-json\/wp\/v2\/media?parent=3259"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/indiangenericmedicines.com\/de\/wp-json\/wp\/v2\/product_brand?post=3259"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/indiangenericmedicines.com\/de\/wp-json\/wp\/v2\/product_cat?post=3259"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/indiangenericmedicines.com\/de\/wp-json\/wp\/v2\/product_tag?post=3259"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}