{"id":4437,"date":"2024-02-28T12:03:18","date_gmt":"2024-02-28T12:03:18","guid":{"rendered":"https:\/\/indiangenericmedicines.com\/?post_type=product&#038;p=4437"},"modified":"2024-02-28T12:16:12","modified_gmt":"2024-02-28T12:16:12","slug":"ebunat-eribulin-mesylate","status":"publish","type":"product","link":"https:\/\/indiangenericmedicines.com\/pt\/oncology\/ebunat-eribulin-mesylate\/","title":{"rendered":"Ebunat (Eribulin Mesylate)"},"content":{"rendered":"<p style=\"text-align: justify;\"><span style=\"font-weight: 400;\"><strong>Eribulin Mesylate<\/strong>, supplied generically under the brand <\/span><span style=\"font-weight: 400;\"><strong>Ebunat<\/strong>,<\/span><span style=\"font-weight: 400;\"> is a microtubule inhibitor used for the treatment of patients with:<\/span><\/p>\n<ul style=\"text-align: justify;\">\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Metastatic breast cancer who have previously been treated with at least two chemotherapeutic regimens for their metastatic disease. Before starting this therapy, patients should have already received a type of chemotherapy called an anthracycline and another type called a taxane.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Unresectable or metastatic liposarcoma who have previously been treated with an anthracycline-containing regimen.\u00a0<\/span><\/li>\n<\/ul>\n<p style=\"text-align: justify;\"><b>Dosage and Side Effects: <\/b><span style=\"font-weight: 400;\">The recommended dosage of <\/span><span style=\"font-weight: 400;\">Eribulin Mesylate<\/span><span style=\"font-weight: 400;\"> is 1.4 mg per square meter of body surface administered intravenously (IV) over 2-5 minutes on Days 1 and 8 of a 21-day cycle. Reduce the dose of <\/span><span style=\"font-weight: 400;\">Eribulin <\/span><span style=\"font-weight: 400;\">in patients with hepatic impairment or with moderate or severe renal impairment. It is not advisable to mix it with other medicines or administer it with dextrose-containing solutions.\u00a0<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-weight: 400;\">The most common <strong>side effects of <\/strong><\/span><strong>Eribulin Mesylate<\/strong><span style=\"font-weight: 400;\"> in metastatic breast cancer are anemia, neutropenia, nausea, fatigue, peripheral neuropathy, alopecia, and constipation.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-weight: 400;\">The most common side effects of <\/span><span style=\"font-weight: 400;\">Eribulin Mesylate<\/span><span style=\"font-weight: 400;\"> in liposarcoma and leiomyosarcoma are constipation, fatigue, nausea, alopecia, abdominal pain, peripheral neuropathy, and pyrexia.<\/span><\/p>\n<p style=\"text-align: justify;\"><b>Warning and Precautions:<\/b><\/p>\n<ul>\n<li style=\"font-weight: 400; text-align: justify;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Patients with alanine aminotransferase (ALT) or aspartate aminotransferase (AST) &gt;3 x upper limit of normal (ULN) experienced an increased incidence of Grade 4 neutropenia and febrile neutropenia. Monitor complete blood counts (CBC) before each dose; increase the frequency of monitoring in those who develop Grade 3\/4 cytopenias.<\/span><\/li>\n<li style=\"font-weight: 400; text-align: justify;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Peripheral neuropathy may develop in patients with metastatic breast cancer (MBC) receiving treatment with <\/span><span style=\"font-weight: 400;\">Eribulin<\/span><span style=\"font-weight: 400;\">. Monitor patients precisely for signs of peripheral motor and sensory neuropathy. Withhold <\/span><span style=\"font-weight: 400;\">Eribulin<\/span><span style=\"font-weight: 400;\"> in those who experience Grade 3\/4 peripheral neuropathy, until resolution to Grade 2 or less.<\/span><\/li>\n<li style=\"font-weight: 400; text-align: justify;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Findings and mechanism of action suggest that <\/span><span style=\"font-weight: 400;\">Eribulin 1 mg per 2 mL (0.5 mg per mL)<\/span> <span style=\"font-weight: 400;\">can cause fetal harm if administered to a pregnant woman. Women who could become pregnant should use birth control during treatment and for 2 weeks after the last dose.<\/span><\/li>\n<li style=\"font-weight: 400; text-align: justify;\" aria-level=\"1\"><span style=\"font-weight: 400;\">QT prolongation may occur. ECG monitoring is required if therapy is initiated in individuals with congestive heart failure, bradyarrhythmias, or drugs known to prolong the QT interval. Correct hypokalemia or hypomagnesemia before initiating <\/span><span style=\"font-weight: 400;\">Eribulin<\/span><span style=\"font-weight: 400;\"> and monitor these electrolytes periodically during therapy. Avoid the use of Eribulin in those with congenital long QT syndrome.<\/span><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<ul>\n<li><b>Medicine Name-<\/b><span style=\"font-weight: 400;\"> Ebunat<\/span><\/li>\n<li><b>API-<\/b> <span style=\"font-weight: 400;\">Eribulin Mesylate<\/span><\/li>\n<li><b>Packaging-<\/b> <span style=\"font-weight: 400;\">Single-use vial<\/span><\/li>\n<li><b>Strength- <\/b><span style=\"font-weight: 400;\">0.5 mg\/mL<\/span><\/li>\n<li><b>Manufactured by- <\/b><span style=\"font-weight: 400;\">Natco<\/span><\/li>\n<\/ul>","protected":false},"featured_media":4438,"template":"","meta":[],"product_brand":[],"product_cat":[18],"product_tag":[],"class_list":["post-4437","product","type-product","status-publish","has-post-thumbnail","product_cat-oncology","first","instock","shipping-taxable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/indiangenericmedicines.com\/pt\/wp-json\/wp\/v2\/product\/4437","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/indiangenericmedicines.com\/pt\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/indiangenericmedicines.com\/pt\/wp-json\/wp\/v2\/types\/product"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/indiangenericmedicines.com\/pt\/wp-json\/wp\/v2\/media\/4438"}],"wp:attachment":[{"href":"https:\/\/indiangenericmedicines.com\/pt\/wp-json\/wp\/v2\/media?parent=4437"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/indiangenericmedicines.com\/pt\/wp-json\/wp\/v2\/product_brand?post=4437"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/indiangenericmedicines.com\/pt\/wp-json\/wp\/v2\/product_cat?post=4437"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/indiangenericmedicines.com\/pt\/wp-json\/wp\/v2\/product_tag?post=4437"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}