Crizotinib

  • Medicine Name- Crizalk
  • API- Crizotinib
  • Packaging- Capsules
  • Strength- 200 mg and 250 mg
  • Manufactured by: Pfizer Ltd.
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Description

Crizotinib 250 mg Capsule is approved to treat certain types of lung cancer prevalent in humans. It is a kinase inhibitor used for the treatment of 

    • Patients with metastatic non-small cell lung cancer (NSCLC) whose tumors are ALK/ROS1-positive. 
    • Pediatric patients aged 12 months and older and young adults with relapsed or refractory, systemic anaplastic large cell lymphoma (ALCL) that is ALK-positive. 
    • Adult and pediatric patients aged 12 months and older with unresectable, recurrent, or refractory inflammatory myofibroblastic tumor (IMT) that is ALK-positive.

Dosage and Side Effects of Crizotinib Capsule

  • Metastatic NSCLC: The recommended dosage for patients with metastatic non-small cell lung cancer (NSCLC) is 250 mg. 
  • Systemic ALCL: The recommended dosage for patients with systemic anaplastic large cell lymphoma (ALCL) is 280 mg/m2 based on body surface area. 
  • Unresectable IMT: The recommended dosage for adults is 250 mg and 280 mg/m2 for pediatric patients based on body surface area. 

Take Crizotinib capsules orally twice daily with or without food. Swallow them whole without crushing, chewing, breaking, or opening. If a dose is missed, make up that dose unless the very next dose is due within 6 hours. If vomiting occurs after taking a dose, take the next scheduled dose at the regular time.

The most common side effects of Crizotinib Capsule in adult patients with NSCLC are nausea, diarrhea, vomiting, vision disorders, constipation, decreased appetite, elevated transaminases, fatigue, neuropathy, upper respiratory infection, edema, and dizziness. 

The most common side effects of Crizotinib Capsule in patients with ALCL are vomiting, diarrhea, nausea, vision disorder, musculoskeletal pain, headache, decreased appetite, stomatitis, fatigue, pyrexia, abdominal pain, cough, and pruritus.

The most common side effects of Crizotinib capsules in adult patients with IMT are nausea, edema, and vision disorders.

The most common side effects of Crizotinib Capsule in pediatric patients with IMT are nausea, vomiting, diarrhea, abdominal pain, cough, rash, vision disorder, pyrexia, musculoskeletal pain, fatigue, edema, constipation, upper respiratory tract infection, and headache.

Warning and Precautions

  • Drug-induced hepatotoxicity with fatal outcomes may occur. Monitor liver function tests, including AST, ALT, and total bilirubin, every 14 days during the initial 60 days of therapy, then once monthly, and as clinically required, with more frequent repeat testing for increased liver transaminases, alkaline phosphatase, or total bilirubin in individuals who develop increased transaminases. 
  • Severe, critical, or fatal interstitial lung disease (ILD) or pneumonitis can occur in those treated with Crizotinib 200 mg/250 mg. Monitor individuals for pulmonary signs and symptoms of ILD or pneumonitis. Exclude other probable causes of ILD or pneumonitis, and permanently stop this treatment in those diagnosed with drug-related ILD or pneumonitis.
  • QTc prolongation may be established in those treated with Crizotinib. Avoid the use of this drug in those with congenital long QT syndrome. Monitor electrolytes and ECGs in individuals with bradyarrhythmias, congestive heart failure, electrolyte abnormalities, or who are taking drugs that are known to prolong the QT interval.
  • Crizotinib capsules can cause serious gastrointestinal toxicities in both pediatric and young adult patients with ALCL or pediatric patients with IMT. Provide standard antidiarrheal and antiemetic agents for gastrointestinal toxicities in both pediatric and young adult patients with ALCL or pediatric patients with IMT. Antiemetics are recommended before and throughout treatment to prevent vomiting and nausea.
  • Based on its mechanism of action, this medicinal product can cause fetal harm if administered to a pregnant woman. Females of reproductive age or potential should use effective contraception during treatment and for at least 45 days following the final dose. 

FAQ's

What is Crizotinib?

Crizotinib Capsule is a targeted therapy medicine prescribed to treat patients with metastatic non-small cell lung cancer (NSCLC), relapsed or refractory, systemic anaplastic large cell lymphoma (ALCL), and unresectable, recurrent, or refractory inflammatory myofibroblastic tumor (IMT).

How do I take Crizotinib

Crizotinib is commercially available in 200 mg and 250 mg capsules which are taken by mouth (orally). 

How much does the Crizotinib Capsule cost in India?

The Crizotinib Capsule cost in India is very reasonable and can vary. To procure this therapeutic drug legally, you can call us at (+91) 8130290915, TOLL-FREE: 1800-889-1064, Or Write us at info@indiangenericmedicines.com.

Can Crizotinib be used while I’m pregnant?

Crizotinib Capsules may be not safe in case used during pregnancy. Discuss with your physician about the other ways to help control your disease if you want to become pregnant or during pregnancy. 

Can Crizotinib be used while breastfeeding?

Avoid breastfeeding while on Crizotinib Capsules. Discuss with your physician if you are breastfeeding or intend to breastfeed.

Where can I get Crizotinib at the best Price? 

Order Crizotinib 250 mg Capsules at the best price today. We request you to Call/WhatsApp us at (+91) 8130290915 or dial our TOLL-FREE Number: 1800-889-1064 or Write us at info@indiangenericmedicines.com. We’re fully committed to providing you with the best Crizotinib price from India. That is why we’ll match the cost/price of any other existing facilitators/suppliers/distributors in the market who require a medical prescription.

Is Crizotinib available in India?

Crizotinib Capsules is a (prescription drug, doctor-prescribed medication, or health care professional-prescribed medicine) pharmaceutical drug that can be legally dispensed against a medical prescription. Crizotinib can be made available through the network of authorized distributors in India. (Ahmedabad, Mumbai, Kolkata, Bangalore, Hyderabad, Chennai, Delhi, Pune, etc.)

Can You Send the Crizotinib to a Foreign Destination?

Buy Crizotinib Capsules online at the best/lowest price from a leading supplier. Indian Generic Medicines (IGM) can assist in the delivery of Crizotinib; the doctor-prescribed medication to the UK, Canada, Australia, Philippines, the USA, South Africa, Saudi Arabia, Thailand, China, Kazakhstan, Uzbekistan, Singapore, Zambia, Hong kong, UAE, Pakistan, Kuwait, Sri Lanka, Sweden, Turkey, Afghanistan, Malaysia, Qatar, Nepal, Japan, and many other countries.

What is the procedure to buy Crizotinib from Indian Generic Medicines

Patients can fill out the order form or send mail to info@indiangenericmedicines.com. Patients can also send WhatsApp messages to +91 8130290915 or can dial the TOLL-FREE Number: 18008891064. We will reply ASAP with the details of the Crizotinib 200 mg/250 mg Capsule price as well as the procurement procedure.

Note:- The order will be confirmed only after the valid receipt of the prescription from the Physician.