Capecitabine

Capecitabine

Innovator Name- Xeloda

API- Capecitabine

Packaging- 10×10 Tablets

Strength- 500mg

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Description

Capecitabine is a specific nucleoside metabolic inhibitor with antineoplastic activity indicated for:

  • Adjuvant Colon Cancer: Patients with Dukes’ C colon cancer.
  • Patient With Metastatic Colorectal Cancer:  First-line as monotherapy when treatment with fluoropyrimidine therapy alone is preferred. 
  • Metastatic Breast Cancer: In combination with docetaxel after failure of prior anthracycline containing therapy.
  • As monotherapy in patients resistant to both paclitaxel and an anthracycline-contain.

Dosage and Side Effects

  • Capecitabine should be taken orally at about the same time each day, either with or without food (within 30 minutes of a meal).
  • Capecitabine 500 mg tablet should be swallowed whole with water. The capsules should not be opened, dissolved, broken, or chewed.

Common side effects of Capecitabine include chest pain, shortness of breath, feeling faint, irregular heartbeats or skipping beats, sudden weight gain, swollen ankles or legs, diarrhea, unexpected tiredness, dehydration, vomiting, weakness and abdominal pain.

Warning and Precautions

  • Patients with mild as well as moderate renal impairment at baseline should be carefully monitored for adverse reactions.
  • Severe mucocutaneous reactions, some with fatal outcomes, such as Stevens-Johnson syndrome and Toxic Epidermal Necrolysis (TEN) can occur in patients treated with Capecitabine.
  • Patients receiving therapy with Capecitabine should be monitored under the experienced physician.
  • Females of childbearing potential must be advised to avoid pregnancy while on Capecitabine.
  • Diarrhea carrying patients should be carefully monitored and given fluid and electrolyte replacement if they become dehydrated.

FAQ's

How does Capecitabine work in the body?

Capecitabine is converted into 5-fluorouracil (5-FU), and cells metabolize it into 5-fluoro-2’-deoxyuridine monophosphate and 5-fluorouridine triphosphate, which stops cell making and damage the repairing of DNA and cancer cells need to make DNA to grow and multiply.

What are the other ingredients in medicine containing Capecitabine?

Capecitabine is the active ingredient and other inactive ingredients: are anhydrous lactose, croscarmellose sodium, hydroxypropyl methylcellulose, microcrystalline cellulose, magnesium stearate.

What are the uses of Capecitabine 500 mg tablet?

Capecitabine is used in the treatment of Colorectal Cancer, Breast Cancer and Gastric Cancer (off-label in the USA).
 
Who should not take Capecitabine?
Patients who are allergic to the ingredients of the medicine should not take Capecitabine. Patients with severe kidney problems.
 
From where i can buy Capecitabine?

  • Capecitabine price is low if you buy generic brand over Innovator, You can buy it from any authorized whole seller after getting prescription from a qualified doctor. It is always better to check the credential of the whole seller/supplier/exporter before buying the product.
  • The buyer should check the existing law in their home country before importing the product.

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