Pazopanib

  • API- Pazopanib hydrochloride
  • Packaging- Tablets
  • Pack Size- 30 Tablets
  • Strength- 200 mg & 400 mg
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Description

Introduction to Pazopanib Tablets

Uses of Medicine: Pazopanib 200 mg/400 mg is an antineoplastic drug that belongs to the class of tyrosine kinase inhibitors. Patients, Healthcare Professionals, or Hospitals can buy Pazopanib 200 mg/400 mg Tablets online from India through Indian Generic Medicines (a trusted Pazopanib Supplier, Exporter, and Contract Manufacturer in India) for the management and treatment of adults with:

  • Advanced renal cell carcinoma (RCC).
  • Advanced soft tissue sarcoma (STS) who have received prior chemotherapy.

Limitations of Use: The efficacy of Pazopanib for the treatment of patients with adipocytic soft tissue sarcoma or gastrointestinal stromal tumors (GISTs) has not been demonstrated.

Pazopanib 200 mg/400 mg tablet works by blocking the enzymes associated with the development and metastasis of cancer cells. It is mainly indicated in the management of some cancers, such as renal cell carcinoma and soft tissue sarcoma. But before initiating this therapy, it is important to tell the physician of any other medical conditions, such as kidney, heart, lung, or liver problems. Also, those with bleeding diathesis or thyroid, or any other abdominal problems should alert the doctor. Treatment with Pazopanib 200 mg/400 mg requires cautious and regular checks of blood pressure because the medication could lead to elevated readings.

Patients with kidney disease do not have any restrictions when it comes to using Pazopanib 200 mg/400 mg in terms of dose adjustment. It is still important, though, to observe the medical doctor on those specific steps to follow regarding the intake of the medicine. As an example of these instructions, you might be informed to discontinue use of the medicine at least 7 days before any surgical or dental operations; this is because of the possibility of impaired healing post-surgery.

Dosage strength of 200 mg/400 mg is advised against in people under the age of 18. Besides that, the medication in question is likely to lead to an impaired ability to conceive, thus asking those who are considering childbearing to consult the physician before its use.

Side effects due to 200 mg/400 mg are typically manageable, it’s essential to keep your healthcare provider informed about any reactions or concerns that may arise during the course of treatment. Always follow your doctor’s advice and attend regular check-ups to ensure the medication is working as expected and to manage any side effects.

Dosage and Side Effects

The recommended dosage of Pazopanib is 800 mg (four 200 mg tablets) orally once daily without food (at least 60 minutes before or 120 minutes after a meal) until there is evidence of disease progression or unacceptable toxicity. Swallow tablets whole. It is not advisable to crush tablets due to the potential for an increased rate of absorption, which may affect systemic exposure. The dosage needs to be modified for hepatic impairment and in those taking certain concomitant medicines. If a dose is missed, it need not be taken if it is < 12 hours until the very next scheduled dose.

The most common side effects of Pazopanib 200 mg/400 mg tablets are:

  • RCC: diarrhea, nausea, hypertension, hair color changes (depigmentation), anorexia, and vomiting.
  • STS: fatigue, nausea, diarrhea, decreased weight, vomiting, hypertension, decreased appetite, headache, tumor pain, hair color changes, musculoskeletal pain, dyspnea, dysgeusia, and skin hypopigmentation.

Warning and Precautions

  • Pazopanib can be responsible for causing liver damage. Liver damage is a possible side effect of pazopanib treatment. Regular monitoring of liver function is advised. Liver toxicity signs – such as jaundice or liver inflammation – should be watched, and treatment may need to be stopped accordingly.
  • This therapeutic drug may be responsible for causing QT interval prolongation. Electrocardiograms (ECGs) need to be monitored regularly as well, particularly in cardiovascular patients and those taking other drugs known to prolong the QT interval.
  • Treatment with this oral therapeutic drug may induce heart failure and a decline in cardiac output. Patients need to be monitored for dyspnea, exhaustion, or edema. Treatment may need to be stopped if heart failure symptoms worsen.
  • The risk of bleeding can be increased with the use of Pazopanib treatment. Patients should be under constant observation for bleeding symptoms such as epistaxis, hematochezia, or hematuria. Any bleeding should be responded to immediately.
  • There is a risk with pazopanib treatment of developing arterial thrombosis, which may result in a heart attack or stroke. Patients should be monitored for chest pain, weakness, and difficulty, and treatment should be sought urgently if they do.
  • Treatment with this therapeutic drug can be responsible for causing deep vein thrombosis or pulmonary embolism. Watch for signs like swelling, pain, or redness in the legs, and shortness of breath. Seek prompt care if any symptoms appear.
  • Pazopanib has been associated with thrombotic microangiopathy (TMA), leading to blood cell damage and organ injury. Monitor kidney function as well as blood cell counts regularly during treatment.
  • This oral therapeutic drug may cause gastrointestinal perforations or fistulas. Monitor patients for signs like vomiting, abdominal pain, or changes in bowel habits, and seek medical attention if these symptoms arise.
  • This medicine may cause interstitial lung disease (ILD) or pneumonitis, which causes breathing difficulties. Report new or worsening cough, fever, or difficulty breathing promptly to a healthcare provider (HCP).
  • Pazopanib can cause high blood pressure. Regular monitoring of blood pressure is required. Antihypertensive treatment should be initiated if blood pressure increases significantly during therapy.
  • In some cases, this therapeutic drug may lead to tumor lysis syndrome (TLS), which can cause kidney failure and electrolyte imbalances. Hydrate patients well and monitor for symptoms like muscle cramps, nausea, and changes in urination.
  • Pazopanib 200 mg/400 mg may damage a developing fetus. Women who are pregnant or wish to become pregnant should not take this drug. Contraceptive measures need to be adhered to during treatment and after the drug is stopped.

FAQ's

What is Pazopanib?

Pazopanib is a prescription medication supplied in the form of Tablets: 200 mg and 400 mg. It is used to treat advanced renal cell carcinoma (kidney cancer) and soft tissue sarcoma (cancer of soft tissues).

How should I take Pazopanib 200 mg/400 mg Tablet?

Take Pazopanib 200 mg/400 mg orally with or without food as directed by your doctor, usually once daily. Follow your doctor’s instructions carefully.

How can I store Pazopanib 200 mg/400 mg Tablet?

Store Pazopanib 200 mg/400 mg at 20°C to 25°C (68°F to 77°F), excursions permitted between 15°C and 30°C (59°F and 86°F). Store it away from moisture and heat, in its original container with the lid tightly closed.

How much does Pazopanib 200 mg/400 mg Tablet cost in India?

Pazopanib 200 mg/400 mg Tablets are available in India at a very competitive and reasonable price. The cost may vary depending on the supplier and location. For those looking to buy Pazopanib online legally and without hassle, Indian Generic Medicines (IGM) offers can help. To inquire about the current Pazopanib 200 mg/400 mg price in India, simply call us at +91 8130290915 or dial our TOLL-FREE Number 1800-889-1064. You can also email us at info@indiangenericmedicines.com for detailed pricing information and assistance.

Can Pazopanib 200 mg/400 mg Tablet be used while I’m pregnant?

Pazopanib 200 mg/400 mg Tablet may be unsafe if used during pregnancy. Talk to your doctor about the best way to help control your disease if you want to become pregnant or during pregnancy.

Can Pazopanib 200 mg/400 mg Tablet be used while breastfeeding?

Breastfeeding is not recommended while receiving treatment with Pazopanib 200 mg/400 mg Tablets. Talk to your healthcare provider (HCP) if you are breastfeeding or intend to breastfeed.

Where can I get Pazopanib 200 mg/400 mg Tablet at the best Price?

To ensure you receive Pazopanib 200 mg/400 mg Tablet at the most competitive price, kindly reach out to Indian Generic Medicines (IGM) today. We are committed to offering the best prices for Pazopanib from India. We can match or beat the cost offered by other suppliers or distributors in the market. Contact us via Call/WhatsApp at +91 8130290915, or use our TOLL-FREE Number 1800-889-1064. Alternatively, you can email us at info@indiangenericmedicines.com. Please note that a valid medical prescription is required to buy Pazopanib tablets.

Is Pazopanib 200 mg/400 mg Tablet available in India?

Yes, Pazopanib 200 mg/400 mg tablets are available in India as a prescription medication. This oral pharmaceutical drug can be legally obtained through India’s authorized distributor network, which spans major cities such as Hyderabad, Mumbai, Bangalore, Ahmedabad, Delhi, Kolkata, Chennai, and Pune. To buy generic Pazopanib 200 mg/400 mg online from India, a valid prescription from a healthcare professional (HCP) is required. Indian Generic Medicines (IGM) can assist you in sourcing generic Pazopanib from India’s top suppliers.

Can You Send the Pazopanib 200 mg/400 mg Tablet to Foreign Destinations?

Indian Generic Medicines (IGM) specializes in the export and delivery of generic Pazopanib 200 mg/400 mg Tablets at the lowest prices. We facilitate the shipment of Pazopanib tablets to various countries, including but not limited to the UAE, Australia, the USA, Saudi Arabia, Canada, the UK, Germany, France, Belgium, Bulgaria, Brazil, Kenya, Japan, and South Africa. Whether you are located in Australia, North America, South America, Eastern Europe, Western Europe, the Middle East, Africa, Central America, or Asia, IGM can assist in delivering generic Pazopanib as per your requirements. For more information on international shipping options, contact us today.

What is the procedure to buy Pazopanib 200 mg/400 mg Tablet from Indian Generic Medicines?

To buy Pazopanib tablets online from India through Indian Generic Medicines (IGM), patients need to fill out the order form or send an email to info@indiangenericmedicines.com. Alternatively, you can send a WhatsApp message to +91 8130290915 or call our TOLL-FREE Number 1800-889-1064. After receiving your inquiry, we will provide you with the details regarding the Pazopanib 200 mg/400 mg prices in India and the procurement procedure. Please note that your order will only be confirmed once we receive a valid prescription from your physician.

Is it safe to buy Pazopanib 200 mg/400 mg Tablet online from India?

Yes, one can buy Pazopanib 200 mg/400 mg online from India. Buying Pazopanib tablets online from India through Indian Generic Medicines (IGM) is safe, especially if the drug is not registered or unavailable in your country. IGM facilitates the legal export of Pazopanib to various countries. We ensure that you get genuine therapeutic drugs at the best price. Our service ensures compliance with all necessary regulations. We provide a secure and reliable way to access generic Pazopanib tablets from India.