Hepcvir L

  • Medicine Name- Hepcvir L
  • API- Ledipasvir and Sofosbuvir
  • Packaging- 28 Tablets
  • Strength- 90 mg and 400 mg
  • Manufactured by- Cipla Limited
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Description

Hepcvir L Tablet, a generic version of Harvoni, is a fixed-dose combination (FDC) of ledipasvir, a hepatitis C virus (HCV) NS5A inhibitor, and sofosbuvir, an HCV nucleotide analog NS5B polymerase inhibitor, and is used for the treatment of chronic hepatitis C virus (HCV) in adult and pediatric patients aged three years and older:

  • Genotype 1, 4, 5, and/or 6 infection either without cirrhosis or with compensated cirrhosis.
  • Genotype 1 infection with decompensated cirrhosis, together with ribavirin.
  • Genotype 1 and/or 4 infection who are liver transplant recipients either without cirrhosis or with compensated cirrhosis, together with ribavirin.

Dosage and Side Effects

The recommended dosage of Hepcvir L in adult patients with genotype 1, 4, 5, or 6 HCV is one tablet (90 mg ledipasvir and 400 mg sofosbuvir) taken orally once daily with or without food. The daily dosage of ribavirin is weight-based (1000 mg for those <75 kg and 1200 mg for those ≥75 kg) administered orally in 2 divided doses with food. In those with decompensated cirrhosis, the starting dosage of ribavirin is 600 mg and may be titrated up to 1000 mg for those <75 kg and 1200 mg for those ≥75 kg in 2 divided doses with food.

The recommended dosage of Hepcvir L in pediatric patients aged 3 years and older with genotype 1, 4, 5, or 6 HCV using Hepcvir L tablets is based on weight. Pediatric patients weighing at least 35 kg should take one 90 mg/400 mg tablet once daily, patients weighing 17 kg to not more than 35 mg should take one 45 mg/200 mg tablet once daily, patients weighing less than 17 kg should take 33.75 mg/150 mg daily orally with or without food.

The most common side effects of Ledipasvir 90 mg; and Sofosbuvir 400 mg tablets are headache fatigue, and asthenia.

Warning and Precautions

  • Test all patients for evidence of ongoing or prior HBV infection by measuring hepatitis B surface antigen (HBsAg) and hepatitis B core antibody (anti-HBc) prior to initiating HCV treatment with Hepcvir L tablets.
  • Cases of symptomatic bradycardia, as well as serious cardiac arrest and cases that may require pacemaker intervention, may occur when amiodarone is coadministered with Hepcvir L tablets. Coadministration of amiodarone with Hepcvir L is not recommended. 
  • The concomitant use of Ledipasvir; Sofosbuvir and P-gp inducers (such as rifampin and St. John’s wort) may significantly scale down the plasma concentrations of ledipasvir and sofosbuvir and may lead to a decreased therapeutic effect of Hepcvir L tablets. Therefore, the use of this drug with P-gp inducers (such as rifampin or St. John’s wort) is not recommended.
  • Patients taking treatment with Hepcvir L who develop signs or symptoms of bradycardia should seek prompt medical evaluation. Symptoms may include shortness of breath, near-fainting or fainting, chest pains, dizziness or lightheadedness, malaise, weakness, tiredness, confusion, or memory problems.

FAQ's

What is Hepcvir L?

Hepcvir-L is the first once-a-day, fixed-dose oral combination therapy that has been approved for chronic hepatitis C virus (HCV) patients.

Is Hepcvir L a generic brand?

Yes, Hepcvir-L is a generic version of Harvoni tablets. 

Who has launched the generic Hepcvir L?

Cipla has launched the generic Hepcvir-L for treating patients with hepatitis C.

How do I take Hepcvir L

Take Hepcvir L 90mg/400mg tablet in the prescribed dose and duration. Take it with or without food but at the same time daily.

How do I store Ledipasvir and Sofosbuvir?

Store below 30°C (86°F). Dispense this medication only in the original container.  Do not use it if the seal over the bottle opening is missing or broken.

How much does Ledipasvir/Sofosbuvir cost in India?

Ledipasvir; Sofosbuvir cost in India is very reasonable and can vary. To procure it legally, you can call us at (+91) 8130290915, TOLL-FREE: 1800-889-1064, Or Write us at info@indiangenericmedicines.com.

Can Ledipasvir; Sofosbuvir be used while I’m pregnant?

Ledipasvir; Sofosbuvir may be unsafe if used during pregnancy. Talk to your doctor about the best way to control your hepatitis C during pregnancy. 

Can Ledipasvir; Sofosbuvir be used while breastfeeding?

Breastfeeding is not recommended while on Ledipasvir; Sofosbuvir. Talk to your healthcare professional if you are breastfeeding or want to breastfeed.

Where can I get Ledipasvir; Sofosbuvir at the best Price? 

Order Hepcvir L at the best price today. We request you to Call/WhatsApp us at (+91) 8130290915 or dial our TOLL-FREE: 1800-889-1064 or Write us at info@indiangenericmedicines.com. We’re fully committed to providing you with the best Ledipasvir; Sofosbuvir price from India. That is why we’ll match the cost or price of any existing suppliers/facilitators/distributors in the market who require a medical prescription.

Is the Ledipasvir; Sofosbuvir (Hepcvir L) available in India?

Hepcvir L is a (prescription drug, doctor-prescribed medication, or health care professional-prescribed medicine) pharmaceutical drug that can be legally dispensed against a medical prescription. Hepcvir L can be made available through the network of authorized distributors in India. (Mumbai, Ahmedabad, Chennai, Kolkata, Pune, Hyderabad, Bangalore, Delhi, etc.)

Can You Send the Ledipasvir; Sofosbuvir to Foreign Destinations?

Buy Ledipasvir; Sofosbuvir online at the lowest price from a leading supplier. Indian Generic Medicines (IGM) can assist in the delivery of Hepcvir L; the doctor-prescribed medication to the USA, the UK, UAE, Canada, Philippines, Saudi Arabia, Australia, Thailand, South Africa, Kazakhstan, China, Uzbekistan, Sri Lanka, Hong Kong, Zambia, Pakistan, Singapore, Kuwait, Afghanistan, Sweden, Turkey, Malaysia, Qatar, Nepal, Japan, and many other countries.

What is the procedure to buy Hepcvir L from Indian Generic Medicines

Patients can fill out the order form or send mail to info@indiangenericmedicines.com. Patients can also send WhatsApp messages to +91 8130290915 or can dial the TOLL-FREE Number: 18008891064. We will reply ASAP with the details of the generic Hepcvir L price and the procurement procedure.

Note:- The order will be confirmed only after the valid receipt of the prescription from the Physician.

Is it safe to buy Ledipasvir; Sofosbuvir (Hepcvir L) online from India?

Yes, one can buy Ledipasvir; Sofosbuvir (Hepcvir L) online from India-based Indian Generic Medicines if it is not (yet) registered or is unavailable in their respective country. We can facilitate the supply/export of generic Hepcvir L through legal channels.