Nintedanib Capsules

  • Medicine Name- Nintib
  • API- Nintedanib 
  • Packaging- 60 Capsules 
  • Strength- 100 mg, 150 mg
  • Manufactured by- Cipla Ltd.
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Nintedanib capsules received initial U.S. approval in 2014. It’s indicated as a kinase inhibitor for:

    • Idiopathic pulmonary fibrosis (IPF).
    • Chronic fibrosing interstitial lung diseases (ILDs) with a progressive phenotype.
    • To slow pulmonary function decline in systemic sclerosis-associated interstitial lung disease (SSc-ILD).

Dosage and Side Effects of Nintedanib Capsules

The recommended dosage involves taking 150 mg of Nintedanib Capsule twice daily, approximately 12 hours apart with food. Adjustments are necessary for patients with mild hepatic impairment, requiring 100 mg twice daily. Temporary dose reduction, treatment interruption, or discontinuation might be necessary for managing adverse reactions. Liver function tests and pregnancy tests for females of reproductive potential should be conducted before treatment initiation. 

Common adverse reactions include diarrhea, nausea, abdominal pain, vomiting, liver enzyme elevation, decreased appetite, headache, weight decrease, and hypertension.

Warning and Precautions of Nintedanib Capsules

  • Patients with significant liver problems should avoid this medication or seek guidance from a healthcare provider. Adjustments in dosage might be necessary for individuals with mild liver impairment.
  • Females planning to conceive should avoid this medication due to potential harm to fertility. It’s advisable not to use this medication while breastfeeding.
  • Prior to starting Nintedanib, discuss your medical history and family medical background with your healthcare professional.
  • If allergic to this medication or its components, refrain from taking it without consulting a pharmacist or healthcare provider.
  • Patients with a history of gastrointestinal surgeries or certain gastrointestinal conditions should exercise caution. Discontinue the medication if gastrointestinal perforation occurs.


How should Nintedanib be taken?

Nintedanib Capsule is usually taken orally, twice daily, about 12 hours apart. It’s recommended to take it with food.

Can I continue Nintedanib if I miss a dose?

If a dose is missed, take it as soon as remembered on the same day. However, if it’s nearing the time for the next dose, skip the missed dose and resume the regular dosing schedule. Avoid taking a double dose to make up for the missed one.

Are there any notable side effects of Nintedanib?

Common side effects may include gastrointestinal issues (like diarrhea, nausea, liver enzyme elevation, decreased appetite, headaches, and weight changes. Report any unusual or severe side effects to your healthcare provider.

Is it safe to drive or operate heavy machinery while taking Nintedanib?

Nintedanib Capsule might cause dizziness or fatigue in some individuals. Assess your reaction to the medication before engaging in activities requiring alertness. If you experience dizziness or other side effects that might impair your abilities, refrain from driving or operating heavy machinery.

Can I consume alcohol while on Nintedanib?

It’s advisable to avoid alcohol consumption or limit it significantly while taking Nintedanib capsule, as alcohol might exacerbate certain side effects and interact with the medication. Always consult your healthcare provider for personalized advice regarding alcohol use during treatment.