Zoledronic Acid

  • Medicine Name- Zoldria
  • API- Zoledronic acid
  • Pack Size- 5 ml Single-use Vial
  • Strength- 4 mg
  • Manufactured By- Cipla Ltd
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One medication in the bisphosphonate family Zoledronic acid 4 Mg Injection, is prescribed to treat patients with the following conditions:

  • Hypercalcemia in Cancer
  • Solid tumours with multiple myeloma and bone metastases.

Dosage and Side Effects

A medical professional administers Zoledronic acid injection as an infusion into a vein for a duration of 15 minutes. Before and after the treatment, your healthcare provider will ask you to consume a minimum of two glasses of water (500 mL or two cups).

Dyspnea, bone pain, fever, nausea, anaemia, exhaustion, constipation, and vomiting are the most typical adverse effects.

Warning and Precautions

  • Patients receiving zoledronic acid injections need to be adequately hydrated beforehand, and their electrolyte levels should be regularly monitored. 

  • Those with kidney issues should avoid using this medication due to the risk of renal toxicity. Moreover, the 4mg dose of zoledronic acid can lead to a condition called Osteonecrosis of the jaw, so dental procedures should be avoided while undergoing treatment. 

  • Joint, bone, or muscle pain may occur as a side effect; if severe symptoms manifest, discontinuing the use of zoledronate is necessary. 

  • It’s crucial to take contraceptive measures during treatment to prevent pregnancy, as this medication can cause severe harm to a developing fetus. 

  • Prior treatment for hypocalcemia and ensuring adequate vitamin and calcium intake is essential before starting Zoledronic acid therapy.


What is the purpose of zoledronic acid injections?

Zoledronic acid injections are used to treat conditions like osteoporosis and bone complications related to cancer by reducing bone loss and preventing fractures.

What are the potential side effects of zoledronic acid injections?

Side effects can include flu-like symptoms, joint or muscle pain, and, rarely, more severe complications like osteonecrosis of the jaw or kidney problems.

How often are zoledronic acid injections administered?

The frequency of injections can vary based on the condition being treated. For osteoporosis, it might be given once a year, while for cancer-related bone issues, it could be more frequent.