Zoledronic Acid

API-Zoledronic acid

Packaging-Single-use Vial


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ZOLDRIA or Zoledronic acid is a bisphosphonate family of the drug, indicated for the treatment of a patient suffering from:

  • Hypercalcemia of Malignancy
  • Multiple Myeloma and Bone Metastases of Solid Tumors.

Dosage and Side Effects

ZOLDRIA injection is given as an infusion into a vein for 15 minutes by a healthcare practitioner. Your healthcare practitioner will ask you to drink at least two glasses of water (500 mL or 2 cups) prior to and following the treatment.

Most common side effects include dyspnea, bone pain, fever, nausea, anemia, fatigue, constipation, and vomiting.

Warning and Precautions

  • Patients taking zoledronic injection must be rehydrated on a prior basis and monitoring of electrolytes should be on a regular basis.
  • Patients having renal toxicity problems should not take this drug.
  • Use of zoledronic acid 4mg may cause Osteonecrosis of the jaw. Avoid any dental procedure during the treatment.
  • Several types of joint, bone, or muscle pain may occur due to the use of injection. If any severe symptoms occur discontinue the use of zoledronate immediately.
  • This medication can cause serious damage to the fetus. Men or women should use the proper contraceptive measure to avoid pregnancy during the treatment.
  • Hypocalcemia should be treated before starting the treatment with Zoldria. A sufficient amount of Vitamin and calcium should be given.


From which class of drug zoledronic belongs? 

Zoledronic acid belongs to the bisphosphonate family of drugs.

What are the ingredients of the medicine Zoledronic Acid?

The medicine’s active ingredient is Zoledronic acid monohydrate, and the inactive ingredient is sodium chloride, 220 mg of mannitol, 100 mL water for injection, and sodium citrate.

Who should not have Zoledronic acid?

  • People who should not have Zoledronic acid are as follows:
  • Patients who are allergic to the ingredients of the medicine.
  • Patients who are already taking medications have the same active ingredients.
  • Patients with renal impairment.
  • Patients with asthma.
  • Patients with heart-related problems.
  • Pregnant or planning to become pregnant.

What are the commonly reported side effects of Zoledronate? 

Nausea, diarrhea, bone pain, fever, fatigue, and vomiting.

How should zoledronate be administered? 

The medication must be administered only by injection slowly into a vein. Avoid giving by injection into a muscle or under the skin.