Description
Introduction to Mitomycin injection
- The alkylating medication Mitomycin is recommended for treating adult patients with low-grade Upper Tract Urothelial Cancer (LG-UTUC).
Dosage and Side Effects
- Usage Guidelines: Jelmyto is meant for use directly in the pyelocalyceal area. It should not be used intravenously, topically, or taken by mouth.Â
- Pre-Instillation Preparation: Take 1.3 grams of sodium bicarbonate orally the night before, in the morning, and 30 minutes before the instillation procedure. This adds up to a total of 3.9 grams.
- Installation Dosage: The recommended dose of Jelmyto to be instilled is 4 milligrams per milliliter through a ureteral catheter or nephrostomy tube. The total instillation volume should be determined using pyelography measurements, capped at 15 milliliters (equivalent to 60 milligrams of Jelmyto).
- Treatment Schedule: Administer Mitomycin 40 mg once a week for six weeks. If a patient shows a complete response three months after starting Jelmyto, subsequent installations may be given once a month for a maximum of 11 additional sessions.
The most frequent side effects (≥20%) include fatigue, nausea, vomiting, dysuria, ureteric blockage, flank discomfort, urinary tract infection, hematuria, and renal failure.