Bosentan

  • Medicine Name- Bosenat
  • API- Bosentan
  • Packaging- Tablets
  • Strength- 62.5 mg/125 mg
  • Manufactured by- Natco Pharma Ltd
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Description

Bosentan is an endothelin receptor antagonist used for the treatment of individuals with certain types of pulmonary arterial hypertension (PAH), which is a high blood pressure in the vessels of the lungs. It can improve the ability to exercise and can slow the worsening of the physical condition and symptoms. This therapeutic drug lowers high blood pressure in the lungs and lets the heart pump blood more efficiently.

Dosage and Side Effects

The recommended dosage for patients >12 years of age and >40 kg: Initiate at 62.5 mg twice daily with or without food for 4 weeks, and then increase to 125 mg twice daily. 

The recommended dosage for patients with low body weight (<40 kg) and >12 years old: Initial and maintenance dose is 62.5 mg twice daily.

The most common side effects of Bosentan tablets are headache, respiratory tract infection, low blood pressure, fainting, flushing, inflamed nose passages (sinusitis), joint pain, and irregular heart beats.

Warning and Precautions

  • Elevations of AST/ALT associated with Bosentan are dose-dependent, occur both early and late in therapy, typically progress gradually, are generally asymptomatic, and usually may be reversible after therapy interruption or cessation. Aminotransferase elevations also may reverse spontaneously while continuing this treatment.

  • Measure liver aminotransferase levels prior to initiation of Bosentan therapy and then monthly and treatment adjusted accordingly. Discontinue treatment if liver aminotransferase elevations are accompanied by clinical signs and symptoms of hepatotoxicity (such as nausea, abdominal pain, vomiting, fever, jaundice, or unusual lethargy or fatigue).

  • Therapy with Bosentan 62.5 mg/125 mg pills can cause a dose-related reduction in hemoglobin and hematocrit. Check hemoglobin concentrations after 1 and 3 months, and every 3 months thereafter. If a marked reduction in hemoglobin concentration occurs, further evaluation must be undertaken to specify the cause and requirement for specific treatment.

  • Obtain a pregnancy test in females of reproductive age/potential prior to Bosenat treatment, monthly throughout treatment and one month after stopping therapy. Initiate treatment with Bosentan in females of reproductive age/potential only after a negative pregnancy test.

FAQ's

What is Bosenat?

Bosenat is a generic of Tracleer which contains Bosentan as the main component. This oral medication is classified as an endothelin receptor antagonist (ERA) and is used for the treatment of pulmonary arterial hypertension (PAH). The goal of this treatment is to improve exercise ability and slow the progression of the condition.

Who has launched the generic Bosenat?

Natco Pharma has launched the generic Bosenat, as 62.5 mg and 125 mg tablets for oral administration.

How do I take Bosentan

Take Bosentan orally, with or without food. There are 2 FDA-approved doses; 62.5 mg (orange-white and round) or 125 mg (orange-white and oval). Patients’ physicians will determine which strength is right for them.

How do I store Bosentan

Store the tablets of Bosentan at 20-25°C (68-77°F). Excursions are permitted between 15°C & 30°C (59°F & 86°F).

How much does Bosentan cost in India?

Bosentan 62.5 mg/125 mg cost in India is reasonable and can vary. To procure it legally, you can call us at (+91) 8130290915, TOLL-FREE: 1800-889-1064, Or Write us at info@indiangenericmedicines.com.

Can Bosentan be used while I’m pregnant?

Bosentan use may be unsafe during pregnancy. Talk to your physician about the best way to control your condition during pregnancy. 

Can Bosentan be used while breastfeeding?

Avoid breastfeeding while on Bosentan. Talk to your physician in case you are breastfeeding or intend to breastfeed.

Where can I get Bosentan at the best Price? 

Order Bosentan at the best price today. We request you to Call/WhatsApp us at (+91) 8130290915 or dial our TOLL-FREE Number: 1800-889-1064 or Write us at info@indiangenericmedicines.com. We are fully committed to providing you with the best Bosentan 62.5 mg/125 mg price in India. That is why we will match the cost or price of any other existing suppliers/distributors in the market who require a medical prescription.

Is the Bosentan available in India?

Bosentan is a (prescription drug, doctor-prescribed medication, or health care professional-prescribed medicine) pharmaceutical drug that can be legally dispensed against a medical prescription. Bosentan can be made available through the network of authorized distributors in India. (Mumbai, Ahmedabad, Kolkata, Hyderabad, Bangalore, Chennai, Delhi, Pune, etc.)

Can You Send the Bosentan to Foreign Destinations?

Buy generic Bosentan online at the best/lowest price from a leading supplier. Indian Generic Medicines (IGM) can assist in the delivery of oral Bosentan; the doctor-prescribed medication to the UK, Canada, China, South Africa, Australia, Philippines, the USA, Saudi Arabia, Thailand, Kazakhstan, Uzbekistan, Sri Lanka, Zambia, Pakistan, Kuwait, Sweden, Hong kong, Turkey, Afghanistan, Malaysia, Singapore, Qatar, UAE, Japan, Nepal, and many other countries.

What is the procedure to buy Bosentan from Indian Generic Medicines

Patients can fill out the order form or send mail to info@indiangenericmedicines.com. Patients can also send WhatsApp messages to +91 8130290915 or can dial the TOLL-FREE Number: 18008891064. We will reply ASAP with the details of the Bosentan 62.5 mg/125 mg price and the procurement procedure.

Note:- The order will be confirmed only after the valid receipt of the prescription from the Physician.

Is it safe to buy Bosentan (Bosenat) online from India?

Yes, one can buy Bosentan (Bosenat) online from India-based Indian Generic Medicines if it is not (yet) registered or is unavailable in their respective country. We can facilitate the Export of generic Bosentan through legal channels.