• Medicine Name- Mekinist
  • API- Trametinib
  • Packaging- Tablets
  • Strength- 0.5 mg, 2 mg 
  • Manufactured by- Novartis
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Trametinib Tablet is a kinase inhibitor used as a single agent to treat BRAF-inhibitor treatment-naïve patients with unresectable or metastatic melanoma with mutations BRAF V600E/V600K. This therapeutic drug is also used, in combination with medicine dabrafenib, for:

    • The treatment of patients with unresectable or metastatic melanoma with mutations BRAF V600E or V600K.
    • The adjuvant treatment of patients with melanoma with mutations BRAF V600E or V600K, and involvement of lymph node(s), after complete resection.
    • The treatment of patients with metastatic non-small cell lung cancer (NSCLC) with mutation BRAF V600E.
    • The treatment of patients with locally advanced or metastatic anaplastic thyroid cancer (ATC) with mutation BRAF V600E and with no satisfactory locoregional therapy options.
    • The treatment of adult and pediatric patients aged 6 years and older with unresectable or metastatic solid tumors with mutation BRAF V600E who have progressed after prior treatment and have no satisfactory alternative therapy options. (This indication of Trametinib is approved under accelerated approval on behalf of the overall response rate and duration of response).
    • The treatment of pediatric patients aged 1 year and older with low-grade glioma (LGG) with a mutation BRAF V600E who require systemic therapy.

Dosage and Side Effects of Trametinib Tablets

The recommended dosage of Trametinib tablets in adults is 2 mg orally once daily. The recommended dosage in pediatric patients is based on body weight. Patients weighing 26 kg to 37 kg should take 1 mg orally once daily, patients weighing 38 kg to 50 kg should take 1.5 mg orally once daily, and patients weighing 51 kg or greater should take 2 mg orally once daily. Take Trametinib at least 1 hour prior to or at least 2 hours after a meal without crushing or breaking the tablets.

The most common side effects of Trametinib tablet as a single agent include diarrhea, rash, and lymphedema. Side effects of Trametinib in combination with dabrafenib include:

  • Unresectable or metastatic melanoma: hypertension, pyrexia, nausea, chills, diarrhea, vomiting, rash, and peripheral edema.
  • Adjuvant treatment of melanoma: headache, pyrexia, nausea, fatigue, chills, diarrhea, vomiting, rash, arthralgia, and myalgia.
  • NSCLC: vomiting, pyrexia, fatigue, nausea, hemorrhage, diarrhea, dry skin, decreased appetite, edema, chills, rash, cough, and dyspnea.
  • Adult patients with solid tumors: headache, pyrexia, fatigue, nausea, rash, chills, hemorrhage, cough, vomiting, constipation, diarrhea, myalgia, arthralgia, and edema.
  • Pediatric patients with solid tumors: vomiting, pyrexia, fatigue, cough, diarrhea, headache, dry skin, abdominal pain, dermatitis acneiform, nausea, hemorrhage, constipation, paronychia, and rash.
  • Pediatric patients with LGG: vomiting, pyrexia, rash, headache, musculoskeletal pain, diarrhea, fatigue, dry skin, nausea, abdominal pain, hemorrhage, and dermatitis acneiform.

Warning and Precautions

  • Perform dermatologic assessments prior to initiation of treatment with Trametinib 0.5 mg/2 mg when used along with dabrafenib, every two months while on treatment, and for up to 6 months after discontinuation of the combination.
  • Based on its mechanism of action, dabrafenib may promote the growth as well as development of malignancies with activation of RAS through mutation or other mechanisms. Monitor patients taking this medication along with dabrafenib precisely for signs or symptoms of non-cutaneous malignancies.
  • Hemorrhages, including prime hemorrhages defined as symptomatic bleeding in a severe area or organ, can occur with this treatment. Fatal cases may occur. Permanently discontinue treatment for all Grade 4 hemorrhagic events and for any Grade 3 hemorrhagic events that do not improve.
  • Colitis and gastrointestinal perforation, including fatal outcomes, may develop in patients taking Trametinib 2 mg/0.5 mg oral medication. Monitor patients closely for colitis and gastrointestinal perforations.
  • Cardiomyopathy, including cardiac failure, may occur with Trametinib treatment. Assess LVEF by echocardiogram or MUGA/multi-gated acquisition scan before initiation of Trametinib as a single agent or along with dabrafenib, 1 month after initiation, and then at 2-3-month intervals while on treatment.
  • Assess serum glucose levels upon starting and as clinically suitable when Trametinib treatment is used together with dabrafenib in individuals with preexisting hyperglycemia or diabetes. Start or optimize anti-hyperglycemic medicines as clinically required.


What is Trametinib?

Trametinib is a highly selective, oral reversible inhibitor of kinases MEK1 and MEK2. This medicine is used for the treatment of melanoma, non-small cell lung cancer (NSCLC), anaplastic thyroid cancer (ATC), solid tumors with mutation BRAF V600E, and low-grade glioma (LGG).

How do I take Trametinib? 

Take Trametinib by mouth (orally) as a tablet. Take it once daily at approximately the same time each day.

How do I store Trametinib?

Store refrigerated at 2-8°C (36-46°F). Dispense in the original bottle. Avoid removing desiccant. Protect it from moisture as well as light. Do not place medicine in pill boxes.

How much does Trametinib cost in India?

Trametinib 0.5 mg/2 mg cost in India is very reasonable and can vary. To procure it legally, you can call us at (+91) 8130290915, TOLL-FREE: 1800-889-1064, Or Write us at

Can Trametinib be used while I’m pregnant?

Trametinib may be not safe if used during pregnancy. Call your doctor about the best way to help control your condition during pregnancy. 

Can Trametinib be used while breastfeeding?

Breastfeeding is not recommended while on Trametinib therapy. Call your doctor if you are breastfeeding or want to breastfeed.

Where can I get Trametinib at the best Price? 

Order Trametinib at the best price today. We request you to Call/WhatsApp us at (+91) 8130290915 or dial our TOLL-FREE Number: 1800-889-1064 or Write us at We are fully committed to providing you with the best Trametinib price from India. That is why we’ll match the cost/price of any other existing facilitators/suppliers/distributors in the market who require a medical prescription.

Is Trametinib available in India?

Trametinib is a (prescription drug, doctor-prescribed medication, or health care professional-prescribed medicine) pharmaceutical drug that can be legally dispensed against a medical prescription. Trametinib can be made available through the network of authorized distributors in India. (Bangalore, Ahmedabad, Mumbai, Kolkata, Hyderabad, Chennai, Pune, Delhi, etc.)

Can You Send the Trametinib to Foreign Destinations?

Buy generic trametinib online at the best/lowest price from a leading supplier. Indian Generic Medicines (IGM) can assist in the delivery of Trametinib; the doctor-prescribed medication to the UK, Canada, UAE, Australia, Philippines, the USA, Saudi Arabia, Thailand, China, South Africa, Kazakhstan, Uzbekistan, Hong Kong, Kuwait, Zambia, Sri Lanka, Sweden, Turkey, Afghanistan, Singapore, Malaysia, Qatar, Japan, Nepal, Pakistan, and many other countries.

What is the procedure to buy Trametinib from Indian Generic Medicines

Patients can fill out the order form or send mail to Patients can also send WhatsApp messages to +91 8130290915 or can dial the TOLL-FREE Number: 18008891064. We will reply ASAP with the details of the Trametinib 0.5 mg/2 mg price and the procurement procedure.

Note:- The order will be confirmed only after the valid receipt of the prescription from the Physician.

Is it safe to buy Trametinib online from India?

Yes, one can buy Trametinib online from India-based Indian Generic Medicines (IGM) if this medication is not (yet) registered or is unavailable in their respective country. We can help facilitate the supply/export of Trametinib through legal channels.