Arsenic Trioxide

  • Medicine Name- Arsenox
  • API- Arsenic Trioxide
  • Packaging- 10 Ampules
  • Strength- Injection: 10 mL vial (1 mg/mL)
  • Manufactured by: Intas Pharmaceuticals
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Arsenic trioxide injection is an arsenical that falls under the general group of medicines called antineoplastics. It is used in combination with the drug tretinoin for the treatment of adults with newly diagnosed low-risk acute promyelocytic leukemia (APL: cancer of the blood and bone marrow) whose APL is characterized by the existence of the t(15;17) translocation or PML/RAR-alpha gene expression.

The medicine Arsenic trioxide injection is also used for induction of remission and consolidation in patients with acute promyelocytic leukemia (APL: a form of leukemia) who are refractory to, or have relapsed from, retinoid and anthracycline chemotherapy, and whose disease is characterized by the existence of the t(15;17) translocation or PML/RAR-alpha gene expression.

Dosage and Side Effects:

Newly-diagnosed low-risk APL: 

  • Induction: The recommended dose is 0.15 mg/kg/day intravenously daily in combination with medicine tretinoin until bone marrow remission. Avoid exceeding 60 days.
  • Consolidation: The recommended dose is 0.15 mg/kg/day intravenously (IV) daily for 5 days per week during weeks 1 to 4 of each 8-week cycle for a total of four cycles along with the drug tretinoin. 

Relapsed or refractory APL:

  • Induction: The recommended dose is 0.15 mg/kg/day intravenously daily until bone marrow remission. Avoid exceeding 60 days.
  • Consolidation: The recommended dose is 0.15 mg/kg/day intravenously daily for 25 doses over a period of up to 5 weeks.

 The most common side effects of Arsenic trioxide are abdominal pain, nausea, fatigue, pyrexia, dyspnea, headache, vomiting, tachycardia, diarrhea, hypokalemia, leukocytosis, hyperglycemia, QTc prolongation, cough, hypomagnesemia, insomnia, sore throat, dermatitis, edema, rigors, arthralgia, paresthesia, and pruritus.

Warning and Precautions:

  • Differentiation syndrome (life-threatening or fatal) may occur in those with acute promyelocytic leukemia (APL) treated with Arsenic trioxide. If it is suspected, temporarily withhold treatment and promptly start dexamethasone 10 mg intravenously (IV) every 12 hours and hemodynamic monitoring until elimination of signs and symptoms for at least three days.
  • Patients treated with this drug can develop torsade de pointes, QTc prolongation, and complete atrioventricular block. Before initiating treatment, assess the QTc interval by electrocardiogram, correct pre-existing electrolyte abnormalities, and consider discontinuing medications known to prolong QTc interval. 
  • Severe encephalopathies may occur in patients receiving Arsenic trioxide. Monitor patients for neurological symptoms, such as seizures, confusion, decreased level of consciousness, cognitive deficits, ataxia, visual symptoms, and ocular motor dysfunction. Instruct patients and caregivers on the requirement for precise observation.
  • Wernicke’s encephalopathy may occur in patients receiving this medicine. Monitor patients for nutritional status and neurological symptoms while receiving it. If Wernicke’s encephalopathy is suspected, promptly interrupt treatment and start parenteral thiamine. Monitor until symptoms are eliminated or enhanced and thiamine levels normalize.
  • Those with newly diagnosed low-risk APL treated with Arsenic along with tretinoin experienced alkaline phosphatase, elevated aspartate aminotransferase (AST), and/or serum bilirubin. During treatment, monitor hepatic function tests at least twice a week during induction and at least once a week during consolidation.
  • The active pharmaceutical ingredient (API) of Arsenox, arsenic trioxide, is a human carcinogen. Monitor respective patients for the establishment of second primary malignancies. 
  • This medicinal product can be responsible for causing fetal harm if administered to a pregnant woman. The respective females of reproductive potential should use apt contraception during treatment and for six months after the final dose.


What is Arsenic Trioxide?

Arsenic trioxide is a chemotherapeutic medicinal product used for the treatment of a form of leukemia (acute promyelocytic leukemia or APL).

How Arsenic Trioxide (Arsenox) is supplied? 

Arsenox is an injectable solution supplied in 10-mL, single-use ampules containing 10 mg of arsenic trioxide.

How to store Arsenic Trioxide?

Store at 20-25°C (68-77°F); excursions permitted to 15-30°C (59-86°F). It is not advisable to freeze this medicine. 

How much does Arsenic Trioxide cost in India?

Arsenic trioxide cost in India is very reasonable and can vary. To procure Arsenic Trioxide legally, you can Call us at (+91) 8130290915, TOLL-FREE: 1800-889-1064, Or Write us at

Can Arsenic Trioxide be used while I’m pregnant?

Arsenic trioxide may be unsafe if used during pregnancy. Talk to your clinician about the best way to help control your disease if you are looking to become pregnant or during pregnancy. 

Can Arsenic Trioxide be used while breastfeeding?

Breastfeeding is not recommended while on Arsenic trioxide treatment. Talk to your clinician in case you are breastfeeding or intend to breastfeed.

Where can I get Arsenic Trioxide at the best Price? 

Order Arsenic trioxide at the best price today. We request you to Call/WhatsApp us at (+91) 8130290915 or dial our TOLL-FREE Number: 1800-889-1064 or Write us at We’re fully committed to providing you with the best Arsenic trioxide price from India. That is why we’ll match the cost/price of any other suppliers/distributors in the market who require a medical prescription.

Is Arsenox (Arsenic Trioxide) available in India?

Arsenox (Arsenic Trioxide) is a (prescription drug, doctor-prescribed medication, or healthcare specialist prescribed medicine) pharmaceutical drug that can be legally dispensed against a medical prescription.

Arsenox (Arsenic Trioxide) can be made available through the network of authorized distributors in India. (Mumbai, Kolkata, Hyderabad, Chennai, Ahmedabad, Delhi, Bangalore and Pune etc.)

Can You Send the Arsenic Trioxide to a Foreign Destination?

Buy generic Arsenic trioxide (Arsenox) online at the best price from India`s leading supplier/exporter. Indian Generic Medicines (IGM) can assist in the delivery of Arsenox (Arsenic Trioxide), doctor-prescribed medicine to the USA, the UK, Canada, Australia, China, Thailand, South Africa, Saudi Arabia, Zambia, Pakistan, Qatar, Kuwait, Sweden, Hong kong, UAE, Philippines, Kazakhstan, Turkey, Singapore, Malaysia, Sri Lanka, Nepal, Uzbekistan Afghanistan, Japan, and many more countries.

What is the procedure for buying Arsenic Trioxide from Indian Generic Medicines (IGM)

Patients can simply fill out the order form or send mail to Patients can also send WhatsApp messages to +91 8130290915 or can dial the TOLL-FREE Number: 18008891064. We will reply ASAP with the details of the Arsenic Trioxide price and the procurement procedure.

Note:- The order will be confirmed only after the valid receipt of the prescription from the Physician.

Is it safe to buy Arsenic Trioxide (Arsenox) online from India?

Yes, one can buy Arsenic trioxide online from India-based Indian Generic Medicines if this medication is not (yet) registered or is unavailable in their respective country. We can facilitate the export of Arsenic trioxide through legal channels.