Thiotepa 15 mg & 100 mg Injection

Thiotepa 15 mg & 100 mg Injection

  • Medicine Name- Thiomed
  • API- Thiotepa
  • Packaging- Single-use vial
  • Strength- 15 mg, 100 mg
  • Manufactured by-  Samarth Life Sciences Pvt Ltd
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Description

It is a type of alkylating agent used for the following conditions:

  • Treating Adenocarcinoma in the Breast or Ovary.

  • Managing intracavitary effusions related to neoplastic diseases in various serosal cavities.

  • Addressing Superficial Papillary Carcinoma in the Urinary Bladder.

  • Minimizing the risk of graft rejection in pediatric patients with Class 3 Beta-Thalassemia undergoing allogeneic HSCT, especially when used alongside higher doses of busulfan and cyclophosphamide as a preparative regimen.

Dosage and Side Effects

Thiotepa dose should be administered intravenously by a qualified healthcare provider.

The common side effects of thiotepa include vomiting, abdominal pain, nausea, anorexia, fatigue, rash, weakness, urticaria, laryngeal edema, anaphylactic shock, asthma, wheezing, contact dermatitis, pain at the injection site, vision dizziness, blurred vision, headache, dysuria, urinary retention, chemical cystitis, amenorrhea, conjunctivitis and interference with the spermatogenesis.

Warning and Precautions

  • Do not administer live or weakened viral or bacterial vaccines to a patient undergoing this treatment until the immune system’s suppressive effects have subsided.

  • This treatment may cause severe skin reactions like discoloration, blistering, itching, and peeling, especially in specific areas like the groin, skin folds, armpits, neck, and under bandages.

  • Advise patients to shower or bathe at least twice daily for 48 hours following this treatment.

  • Monitor patients’ liver enzymes and bilirubin daily until BMT Day +28 and offer supportive care for those developing hepatic veno-occlusive disease.

  • Febrile reactions and discharge from a skin lesion might occur due to tumor tissue breakdown.

  • Inform patients about potential low blood cell counts and the need for hematopoietic progenitor cell infusion.

  • Some patients experienced prolonged apnea after succinylcholine administration before surgery, following combined use of thiotepa 15 mg with other anticancer drugs.

  • Patients should promptly report any bleeding or fever to their doctor.

  • Educate patients about hypersensitivity symptoms and advise seeking emergency help if they experience any.

  • Males using this drug should use effective contraception with female partners and continue this for at least 12 months after the final dose of Thiotepa.

  • This medication may cause harm to a fetus. Females taking it should avoid pregnancy during treatment and for at least six months after the last dose.

  • Females should report pregnancy as soon as possible.

  • Inform patients that this medication might lead to infertility. Male patients should consider sperm conservation before starting treatment.

  • Patients should refrain from breastfeeding while on this medication.

  • Explain to patients that this drug might elevate the risk of developing another type of cancer.

FAQ's

What is Thiotepa, and what conditions is it used to treat?

Thiotepa is a chemotherapy medication used to treat various cancers, including adenocarcinoma of the breast or ovary, superficial papillary carcinoma of the urinary bladder, malignant effusions, and certain types of thalassemia.

How does Thiotepa work in the body?

Thiotepa works by interfering with the growth and spread of cancer cells. It is classified as an alkylating agent, disrupting the DNA structure within cancer cells to prevent them from multiplying.

Are there any precautions or considerations before taking Thiotepa?

Before starting Thiotepa, patients and healthcare providers should discuss potential side effects, especially related to skin reactions, liver function, and the risks of pregnancy or fertility issues. Patients should also avoid live vaccines during treatment due to its impact on the immune system.

What are the potential side effects of Thiotepa?

Common side effects may include skin discoloration, severe skin reactions, fever, bleeding, liver complications, and low blood cell counts. Patients should promptly report any unusual symptoms to their healthcare provider.

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