Liposomal Amphotericin B

  • Medicine Name- Amphonex
  • API- Liposomal Amphotericin B
  • Packaging- Single-dose vial
  • Strength- 50mg/vial
  • Manufactured by- Bharat Serums & Vaccines Ltd
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Description

Liposomal Amphotericin B 50 mg injection is a treatment of invasive fungal infection in patients who are refractory to or intolerant of conventional amphotericin B therapy. This antifungal and an antiprotozoal medicine is used for:

  • Empirical therapy for presumed fungal infection in febrile, neutropenic patients.
  • Treatment of Cryptococcal Meningitis in HIV-infected patients.
  • Treatment of patients with Aspergillus species, Candida species, and/or Cryptococcus species infections refractory to amphotericin B deoxycholate, or in patients where renal impairment or unacceptable toxicity precludes the use of amphotericin B deoxycholate.
  • Treatment of visceral leishmaniasis. In immunocompromised individuals with visceral leishmaniasis treated with Liposomal Amphotericin B, relapse rates were high after initial clearance of parasites.

Dosage and Side Effects

The recommended dosage of Liposomal Amphotericin B should be administered by intravenous infusion, through a controlled infusion device, over a time-span of approximately 120 minutes. The recommended initial dose for each indication for adults and pediatric patients is as follows:

  • For Empirical therapy: The recommended dose is 3 mg/kg/day.

  • For Systemic fungal infections (Aspergillus, Candida, Cryptococcus): The recommended dose is 3 to 5 mg/kg/day.

  • Cryptococcal meningitis in HIV infected patients: The recommended dose is 6 mg/kg/day.

Standard doses of injection of liposomal amphotericin b for visceral leishmaniasis are as follows:

  • For Immunocompetent patients: The recommended dose is 3 mg/kg/day (days 1 to 5) and 3 mg/kg/day on days 14, 21.

  • For Immunocompromised patients: Recommended dose is 4 mg/kg/day (days 1 to 5) and 4 mg/kg/day on days 10, 17, 24, 31, 38.

The most common side effects of Liposomal Amphotericin B are hyperglycemia, hypokalemia, nausea, rash, diarrhea, vomiting, anemia, increased alkaline phosphatase, increased creatinine, increased blood urea nitrogen, hypomagnesemia, chills, insomnia, and dyspnea.

Warning and Precautions

  • Anaphylaxis may occur with amphotericin B deoxycholate and other existing amphotericin B-containing therapeutic drugs, including liposomal amphotericin b injection. If a critical anaphylactic reaction occurs, the infusion needs to be promptly stopped and the patient should not receive further infusions.
  • As with any amphotericin B-containing medicinal product the medicine should be administered by a professionally trained personnel. During the initial dosing period, patients should be under close clinical observation. This medicinal product is significantly less toxic than amphotericin B deoxycholate; however, some side effects may still emerge
  • Patients receiving treatment with this medicine should be monitored for serum potassium, urea, calcium, urine output, magnesium, creatinine, liver function tests, and complete blood count.
  • Renal toxicity basically is dose dependent; dose adjustments need to be considered only after evaluating and considering the patient’s overall clinical picture.

FAQ's

What is Liposomal Amphotericin B?

Liposomal Amphotericin B is a unique lipid formulation of amphotericin B. It is a standard of care for a wide range of medically crucial opportunistic fungal pathogens.

What dosage strengths Liposomal Amphotericin B supplied?

This medicine is supplied as single cartons (equivalent to 50 mg) and in vial cartons for intravenous (IV) administration.

How is Liposomal Amphotericin B administered?

Liposomal Amphotericin B comes as a suspension (liquid) to be injected intravenously (into a vein).

How much does Liposomal Amphotericin B cost in India?

Liposomal Amphotericin B cost in India is very reasonable and can vary. To procure it legally, you can call us at (+91) 8130290915, TOLL-FREE: 1800-889-1064, Or Write us at info@indiangenericmedicines.com.

Where can I get Liposomal Amphotericin B at the best Price? 

Order Liposomal Amphotericin B at the best price today. We request you to Call/WhatsApp us at (+91) 8130290915 or dial our TOLL-FREE: 1800-889-1064 or Write us at info@indiangenericmedicines.com. We are committed to providing you with the best Liposomal Amphotericin B price from India. That is why we’ll match the cost/price of any existing facilitators/suppliers/distributors in the market who require a medical prescription.

Is Liposomal Amphotericin B available in India?

Liposomal Amphotericin B is a (prescription drug, doctor-prescribed medication, or health care professional-prescribed medicine) pharmaceutical drug that can be legally dispensed against a medical prescription. Liposomal Amphotericin B can be made available through the network of authorized distributors in India (Hyderabad, Bangalore, Mumbai, Ahmedabad, Kolkata, Chennai, Delhi, Pune, etc.)

Can You Send the Liposomal Amphotericin B to Foreign Destinations?

Buy generic Liposomal Amphotericin B online at the best/lowest price from a leading supplier. Indian Generic Medicines can assist in the delivery of Liposomal Amphotericin B; the doctor-prescribed drug to the UK, Canada, Saudi Arabia, Thailand, China, Australia, Philippines, the USA, South Africa, Kazakhstan, Zambia, Pakistan, Kuwait, Uzbekistan, Sri Lanka, Sweden, Turkey, Afghanistan, Hong kong, UAE, Malaysia, Japan, Nepal, Singapore, Qatar, and many other countries.

What is the procedure to buy Liposomal Amphotericin B from Indian Generic Medicines

Patients can fill out the order form or send mail to info@indiangenericmedicines.com. Patients can also send WhatsApp messages to +91 8130290915 or can dial the TOLL-FREE Number: 18008891064. We will reply ASAP with the details of the Liposomal Amphotericin B 50mg price and the procurement procedure.

Note:- The order will be confirmed only after the valid receipt of the prescription from the Physician.

Is it safe to buy Liposomal Amphotericin B online from India?

Yes, one can buy Liposomal Amphotericin B online from India-based Indian Generic Medicines (IGM) if it is not (yet) registered or is unavailable in their respective country. We can facilitate the supply/export of Liposomal Amphotericin B through legal channels.