• Medicine Name- Ibrunat
  • API- Ibrutinib
  • Packaging- 30 Capsules
  • Strength- 140 mg
  • Manufactured by- Natco Pharma
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Ibrutinib Capsule is an orally administered, selective and covalent inhibitor of the enzyme called Bruton’s tyrosine kinase (BTK). This oral therapeutic medicine is used for the management and treatment of:

  • Adult patients with mantle cell lymphoma (MCL) who have previously been treated with at least one therapy (This indication of Ibrutinib is approved under accelerated approval on behalf of the overall response rate).
  • Adult individuals with chronic lymphocytic leukemia-CLL/Small lymphocytic lymphoma-SLL.
  • Adult patients with chronic lymphocytic leukemia-CLL/Small lymphocytic lymphoma-SLL with 17p deletion.
  • Adult patients with Waldenström’s macroglobulinemia (WM).
  • Adult patients with marginal zone lymphoma (MZL) who require systemic therapy and have been treated with at least one prior anti-CD20-based treatment (This indication of Ibrutinib 140 mg is approved under accelerated approval on behalf of the overall response rate).
  • Adult and pediatric patients aged 1 year and older with chronic graft versus host disease (cGVHD) after failure of single or multiple lines of systemic therapy.

Dosage and Side Effects

Mantle Cell Lymphoma (MCL) and Marginal Zone Lymphoma (MZL): The recommended dosage for MCL and MZL is 560 mg administered orally once daily until disease progression or unacceptable toxicity.

Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL) and Waldenström’s Macroglobulinemia (WM): The recommended dosage for CLL/SLL and WM is 420 mg orally once daily until disease progression or unacceptable toxicity. For CLL/SLL, Ibrutinib Capsule can be used as a single agent, in combination with medicine rituximab or obinutuzumab, or together with bendamustine and rituximab (BR). For WM, Ibrutinib can be used as a single agent or together with rituximab. 

Chronic Graft versus Host Disease (cGVHD): The recommended dosage for patients aged 12 years and older with cGVHD is 420 mg administered orally once daily, and for patients aged 1 to less than 12 years with cGVHD is 240 mg/m2 given orally once daily (up to a dose of 420 mg), until disease progression, or recurrence of an underlying malignancy, or unacceptable toxicity. Swallow capsules completely through a glass of water. Avoid chewing, opening, or breaking the capsules.

The most common side effects of Ibrutinib Capsule in patients with B-cell malignancies (MCL, CLL/SLL, WM, and MZL) are diarrhea, thrombocytopenia, fatigue, musculoskeletal pain, neutropenia, anemia, bruising, and rash.

The most common adverse reactions in adult or pediatric patients with cGVHD are musculoskeletal pain, fatigue, anemia, diarrhea, bruising, thrombocytopenia, pyrexia, stomatitis, muscle spasms, hemorrhage, nausea, headache, abdominal pain, and pneumonia.

Warning and Precautions

  • Fatal bleeding events may occur in patients who received Ibrutinib Capsule. Use of either antiplatelet or anticoagulant agents concomitantly with Ibrutinib may increase the risk of major hemorrhage. Consider the risks and benefits of antiplatelet or anticoagulant therapy when co-administered with Ibrutinib Capsule. Monitor patients for bleeding-associated signs and symptoms. 
  • Fatal and non-fatal infections (including viral, bacterial, or fungal) may occur with Ibrunat 140 mg Capsule treatment. Monitor and assess all patients for fever and infections and treat them appropriately.  
  • Fatal and critical cardiac arrhythmias and cardiac failure may occur with this medicine. Evaluate cardiac history and function at baseline, and assess patients for cardiac arrhythmias and cardiac function. Obtain further evaluation (such as ECG, or echocardiogram) as required.
  • Hypertension may develop in patients taking treatment with Ibrutinib Capsule. Monitor blood pressure in those treated with Ibrutinib oral drug, initiate or adjust anti-hypertensive medication throughout the treatment as appropriate, and follow dosage modification guidelines for Grade 3 or higher hypertension.
  • Tumor lysis syndrome (TLS) may infrequently develop with Ibrutinib Capsule therapy. Assess the baseline risk (such as high tumor burden) and take all the relevant precautions. Monitor patients precisely and treat them as appropriate.
  • In patients with B-cell malignancies who are receiving treatment with Ibrutinib Capsule as a single agent, grade 3/4 neutropenia, grade 3/4 thrombocytopenia, and grade 3/4 anemia may occur, based on laboratory measurements. Monitor complete blood counts (CBC) monthly.


What is Ibrunat?

Ibrunat Capsule is a generic of Imbruvica that contains Ibrutinib as the major component. This medicinal product is used for the treatment of mantle cell lymphoma (MCL), chronic lymphocytic leukemia (CLL)/Small lymphocytic lymphoma (SLL), Waldenström’s macroglobulinemia (WM), marginal zone lymphoma (MZL), and chronic graft versus host disease (cGVHD).

Who launched the generic Ibrunat?

Natco Pharma Limited launched the Imbruvica generic under the brand name Ibrunat as 140 mg oral capsules.

How do I take Ibrutinib

Ibrutinib is supplied as a capsule to take by mouth (orally). The dosage of this medication is usually taken once daily at the same time.

How do I store Ibrutinib?

Store at room temperature 20-25°C (68-77°F). Brief exposure to 15-30°C (59-86°F) permitted. Retain it in the original package until dispensing. 

How much does Ibrutinib cost in India?

Ibrutinib 140 mg Capsule cost in India is very reasonable and can vary. To procure this kinase inhibitor legally, you can call us at (+91) 8130290915, TOLL-FREE: 1800-889-1064, Or Write us at info@indiangenericmedicines.com.

Can Ibrutinib be used while I’m pregnant?

Ibrutinib capsules may be hazardous during pregnancy. Talk to your healthcare specialist about the best way to manage your disease/condition during pregnancy. 

Can Ibrutinib be used while breastfeeding?

Breastfeeding is not recommended while on treatment with Ibrutinib. Talk to your healthcare specialist if you are breastfeeding or want to breastfeed.

Where can I get Ibrutinib at the best Price? 

Order Ibrutinib Capsule Online At Lowest Prices today. We request you to Call/WhatsApp us at (+91) 8130290915 or dial our TOLL-FREE Number: 1800-889-1064 or Write us at info@indiangenericmedicines.com. We’re fully committed to providing you with the best Ibrutinib Capsule price from India. That is why we’ll match the cost or price of any existing suppliers/distributors/facilitators in the market who require a medical prescription.

Is the Ibrutinib available in India?

Ibrutinib Capsule is a (prescription drug, doctor-prescribed medication, or health care professional-prescribed medicine) pharmaceutical drug that can be legally dispensed against a medical prescription. Ibrutinib Capsule can be made available through the network of authorized distributors in India. (Mumbai, Ahmedabad, Pune, Kolkata, Hyderabad, Bangalore, Chennai, Delhi, etc.)

Can You Send the Ibrutinib to Foreign Destinations?

Buy generic Ibrutinib Capsule online at the best/lowest price from a leading supplier. Indian Generic Medicines (IGM) can assist in the delivery of Ibrutinib Capsule; the doctor-prescribed medication to the UK, Canada, Turkey, Australia, Philippines, Saudi Arabia, Thailand, China, Kazakhstan, Uzbekistan, Zambia, the USA, Pakistan, South Africa, Singapore, Kuwait, Sweden, Malaysia, Hong Kong, UAE, Afghanistan, Qatar, Japan, Nepal, Sri Lanka, and many other countries.

What is the procedure to buy Ibrutinib from Indian Generic Medicines

Patients can fill out the order form or send mail to info@indiangenericmedicines.com. Patients can also send WhatsApp messages to +91 8130290915 or can dial the TOLL-FREE Number: 18008891064. We will reply ASAP with the details of the Ibrutinib 140 mg Capsule price and the procurement procedure.

Note:- The order will be confirmed only after the valid receipt of the prescription from the Physician.

Is it safe to buy Ibrutinib (Ibrunat) online from India?

Yes, one can buy Ibrutinib (Ibrunat) Capsule online from India-based Indian Generic Medicines (IGM) if this drug is not (yet) registered or is unavailable in their respective country. We can facilitate the supply/export of generic Ibrutinib Capsule through legal channels.