Apremilast

  • Medicine Name- Aprezo
  • API- Apremilast
  • Packaging- Tablets
  • Strength- 30mg
  • Manufactured by- Glenmark
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Description

Apremilast is a small molecule phosphodiesterase 4 (PDE4) inhibitor used for treating psoriatic arthritis in adult patients with moderately to severely active disease, plaque psoriasis in adult patients who are prospects for phototherapy or systemic therapy, and adult patients with Behcet disease associated with oral ulcers.

Dosage and Side Effects

The recommended dosing regimen for treating Plaque psoriasis, Psoriatic arthritis, and Behcet disease is initiated as a 5-day titration period, gradually increasing the dose of apremilast over the initial five days until the recommended dose is reached.

  • Day 1 – 10 mg administered in the morning once daily
  • Day 2 – 10 mg administered in the morning and 10 mg administered in the evening
  • Day 3 – 10 mg administered in the morning and 20 mg administered in the evening
  • Day 4 – 20 mg administered in the morning and 20 mg administered in the evening
  • Day 5 – 20 mg administered in the morning and 30 mg administered in the evening
  • Day 6 – 30 mg administered twice daily moving forward

During the treatment initiation, patients need to be started on an Apremilast 10 mg dosage, followed by gradual dosage titration by an increase of 10 mg daily for 6 days, reaching the optimal daily dosage of 30 mg twice daily by day six. Dosage can be administered without regard to meals. Never break, crush, or chew the tablets. 

The most frequently reported side effects of apremilast are suicidal thoughts/ideas, nausea, diarrhea, and depression.

Warning and Precautions

  • Treatment with this medicine is related to a rising incidence of depression. Prior to using this medicine in patients with a known history of depression or suicidal thoughts, prescribers should specifically weigh the risks as well as advantages of treatment with apremilast tablets.

  • Cases of severe diarrhea, vomiting, and nausea may occur with the use of apremilast. Watch over patients who are a bit more sensitive to complications of vomiting or diarrhea. Patients who reduced dosage or halted this treatment generally improved promptly.

  • Hypersensitivity reactions, including cases of angioedema and anaphylaxis, may occur. Avoid the usage of apremilast 30 mg in those with known hypersensitivity to this medicine or any of the excipients in the formulation. If symptoms of serious hypersensitivity reactions develop during therapy, discontinue treatment and institute suitable medicine. 

  • Co-administration of strong cytochrome P450 enzyme inducer, rifampin, may cause a deduction of systemic exposure to apremilast, which may cause a loss of efficacy of Aprezo. Therefore, cytochrome P450 enzyme inducers (e.g., phenobarbital, rifampin, carbamazepine, phenytoin) with Aprezo are not advised.

  • Patients treated with generic apremilast tablets must have their weight monitored regularly. In case a sudden or clinically significant weight loss occurs, weight loss must be assessed, and discontinuation therapy should be considered.

FAQ's

What is Aprezo (Apremilast)?

Aprezo is a generic of Otezla that contains apremilast, as a main component. It is a prescription oral drug used for the treatment of certain types of psoriasis and psoriatic arthritis.

Who has launched the generic Aprezo?

Glenmark has launched the generic Aprezo as a 30 mg tablet for oral consumption.

How do I take Apremilast

Apremilast is supplied in tablet form for oral administration. It may be taken with or without regard. However, it should not be nibbled, granulated, or split.

How do I store Apremilast tablets?

Store the pills of Apremilast below 30°C (86°F).

How much does Apremilast cost in India?

Apremilast 30 mg cost in India is very reasonable and can vary. To procure this oral drug legally, you can call us at (+91) 8130290915, TOLL-FREE: 1800-889-1064, Or Write us at info@indiangenericmedicines.com.

Can Apremilast be used while I’m pregnant?

The use of Apremilast tablets may be unsafe during pregnancy. Contact your healthcare provider about the best way to manage your disease during suspected pregnancy. 

Can Apremilast be used while breastfeeding?

Breastfeeding is not recommended while on Apremilast treatment. Contact your healthcare provider if you are breastfeeding or want to breastfeed.

Where can I get Apremilast tablets at the best Price? 

Order Apremilast at the best price today. We request you to Call/WhatsApp us at (+91) 8130290915 or dial our TOLL-FREE Number: 1800-889-1064 or Write us at info@indiangenericmedicines.com. We’re fully committed to providing you with the best Apremilast 30 mg price from India. That is why we will match the cost/price of any other existing suppliers/distributors in the market who require a medical prescription.

Is Apremilast available in India?

Apremilast is a (prescription drug, doctor-prescribed medication, or health care professional-prescribed medicine) pharmaceutical drug that can be legally dispensed against a medical prescription. Apremilast can be made available through the network of authorized distributors in India. (Hyderabad, Ahmedabad, Mumbai, Kolkata, Bangalore, Delhi, Pune, Chennai, etc.)

Can You Send the Apremilast to Foreign Destinations?

Buy generic Apremilast online at the best/lowest price from a leading supplier. Indian Generic Medicines can assist in the delivery of Apremilast; the doctor-prescribed medication to Australia, the UK, Canada, the Philippines, Saudi Arabia, South Africa, the USA, Thailand, China, Zambia, Pakistan, Sri Lanka, Hong Kong, UAE, Kazakhstan, Uzbekistan, Afghanistan, Sweden, Turkey, Malaysia, Singapore, Kuwait, Qatar, Japan, Nepal, and many other countries.

What is the procedure to buy Apremilast from Indian Generic Medicines

Patients can just fill out the order form or send mail to info@indiangenericmedicines.com. Patients can also send WhatsApp messages to +91 8130290915 or can dial the TOLL-FREE Number: 18008891064. We will reply ASAP with the details of the Apremilast 30 mg price as well as the procurement procedure.

Note:- The order will be confirmed only after the valid receipt of the prescription from the Physician.

Is it safe to buy Aprezo (Apremilast) online from India?

Yes, one can buy Aprezo (Apremilast 30 mg) online from India-based Indian Generic Medicines (IGM) if it is not (yet) registered or is unavailable in their respective country. We can facilitate the supply/export of generic Apremilast through legal channels.