Anti-Thymocyte Globulin-Equine

  • Medicine Name- Atgam
  • API- Anti-Thymocyte Globulin-Equine
  • Packaging- 1 Vial
  • Strength- 250 mg/5 mL
  • Manufactured by- Pfizer Inc
Get an Enquiry
Category:

Description

Atgam 250 mg Injection (Horse anti-human T-lymphocyte immunoglobulin) is a hyperimmune globulin preparation made from the plasma of horses and immunized with human thymocytes or T cells. This immunoglobulin G is used for renal allograft rejection and aplastic anemia (moderate to severe) in individuals not suitable for bone marrow transplantation (BMT).

Limitations of Use: The usefulness of Atgam 250 mg has not been shown in those with aplastic anemia who are suitable candidates for BMT or in patients with aplastic anemia secondary to neoplastic disease, storage disease, myelofibrosis, Fanconi’s syndrome, or in individuals known to have been exposed to myelotoxic agents or radiation.

Dosage and Side Effects

Renal Allograft Rejection: The recommended dosage of ATGAM injection for renal allograft rejection is 10-15 mg/kg daily intravenously for 2 weeks (14 days). Additional alternate-day therapy up to a total of 21 doses may be considered.

Aplastic Anemia (Moderate to Severe): The recommended dosage for aplastic anemia is 10 to 20 mg/kg daily administered intravenously for 8-14 days. Additional alternate-day therapy up to a total of 21 doses may be considered.

The most common side effects of ATGAM are chills, pyrexia, rash, thrombocytopenia, leukopenia, and arthralgia.

Warning and Precautions

  • Cytokine release syndrome may occur with the use of ATGAM injection, which can be fatal. Signs and symptoms may include fever, chills, headache, chest pain, hypotension, dyspnea, tachypnea, and edema. Assess patients for signs and symptoms of cytokine release syndrome and manage them as per clinical guidelines.

  • Anaphylaxis may occur with the use of ATGAM. Anaphylaxis is life-threatening. Stop treatment in case anaphylaxis develops. Rash, dyspnea, tachycardia, and hypotension can be signs/symptoms of an anaphylactic reaction. Assess patients for symptoms of anaphylaxis during infusion and for at least 24 hours after the infusion.

  • Critical infusion-related reactions may occur with the administration of ATGAM 250 mg/5 mL injection. Signs and symptoms associated with infusion-associated reactions include dyspnea, tachycardia, rash, and hypotension. Assess patients for infusion-associated reactions and manage them as per clinical guidelines.

  • Serum sickness is a resisted hypersensitivity or immune reaction. Signs and symptoms of serum sickness may include arthralgia, pyrexia, chills, rash, and pain. Assess all the patients for serum sickness and manage them as per clinical guidelines.

  • Due to the immunosuppressive effects of ATGAM/ATG, opportunistic infections (such as viral, bacterial, and fungal) may occur. Sepsis may also occur. There is an increased probability of viral reactivation (such as cytomegalovirus, Epstein–Barr virus infection, and herpes simplex virus). Assess all the patients for concurrent infection. 

  • Thrombocytopenia and neutropenia may occur with the use of ATG or ATGAM injection. In case thrombocytopenia occurs, consider platelet transfusions to maintain platelets at required levels. Stop treatment in case serious and unremitting thrombocytopenia or neutropenia occurs.

FAQ's

What is ATGAM?

ATGAM is an antibody preparation derived from horses hyperimmunized with human thymocytes, which is used to prevent or treat acute cellular rejection following solid organ transplantation and as a therapy of acute aplastic anemia.

How is ATGAM administered? 

ATGAM is administered as an intravenous (IV, into a vein) infusion, generally in the hospital.

How do I store ATGAM?

Store the vials of ATGAM in a refrigerator at 2-8°C (36-46°F). Never freezing it. Store in the original carton to protect the vials from the light.

How much does ATGAM cost in India?

ATGAM 250 mg/5 mL cost in India is very reasonable and can vary. To procure it legally, you can call us at (+91) 8130290915, TOLL-FREE: 1800-889-1064, Or Write us at info@indiangenericmedicines.com.

Where can I get ATGAM at the best Price? 

Order ATGAM at the best price today. We request you to Call/WhatsApp us at (+91) 8130290915 or dial our TOLL-FREE: 1800-889-1064 or Write us at info@indiangenericmedicines.com. We are committed to providing you with the best ATGAM 250 mg/5 mL price from India. That is why we’ll match the cost or price of any existing facilitators/suppliers/distributors in the market who require a medical prescription.

Is ATGAM available in India?

ATGAM is a (prescription medicine, doctor-prescribed medication, or health care professional-prescribed drug) pharmaceutical drug that can be legally dispensed against a medical prescription. ATGAM can be made available through the network of authorized distributors in India. (Hyderabad, Mumbai, Bangalore, Ahmedabad, Delhi, Kolkata, Chennai, Pune, etc.)

Can You Send the ATGAM to Foreign Destinations?

Buy generic ATGAM online at the best/lowest price from a leading supplier. Indian Generic Medicines can assist in the delivery of ATGAM; doctor-prescribed medication to Australia, Philippines, the USA, Saudi Arabia, Canada, the UK, Thailand, Kazakhstan, Sri Lanka, China, Uzbekistan, Zambia, Pakistan, Singapore, Afghanistan, Malaysia, Kuwait, South Africa, Hong kong, UAE, Turkey, Qatar, Japan, Nepal, and many other countries.

What is the procedure to buy ATGAM from Indian Generic Medicines

Patients can just fill out the order form or send mail to info@indiangenericmedicines.com. Patients can also send WhatsApp messages to +91 8130290915 or can dial the TOLL-FREE Number: 18008891064. We will reply ASAP with the details of the ATGAM 250 mg/5 mL price and the procurement procedure.

Note:- The order will be confirmed only after the valid receipt of the prescription from the Physician.

Is it safe to buy ATGAM online from India?

Yes, one can buy ATGAM 250 mg/5 mL online from India-based Indian Generic Medicines if it is not (yet) registered or is unavailable in their respective country. We can facilitate the supply of ATGAM through legal channels.