- Dimethyl fumarate is indicated for the treatment of patients with relapsing forms of multiple sclerosis.
- Dimethyl fumarate is a white to off-white powder.
The common side-effects of Dimethyl Fumarate are flushing, abdominal pain, diarrhea, and nausea.
Dimethyl Fumarate120 mg may cause lymphopenia. A recent CBC should be available before initiating treatment with Dimethyl Fumarate. A CBC is recommended annually, and as clinically indicated. Consider withholding treatment in patients with serious infections.
What is Dimethyl fumarate used for?
Healthcare professionals recommend using Dimethyl Fumarate in treating patients with relapsing forms of multiple sclerosis.
What is the mechanism of action of dimethyl fumarate?
The mechanism by which Dimethyl fumarate (DMF) exerts its therapeutic effect in multiple sclerosis is unknown. DMF and the metabolite, monomethyl fumarate (MMF), have been shown to activate the Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) pathway in vitro and in vivo in animals and humans. The Nrf2 pathway is involved in the cellular response to oxidative stress. MMF has been identified as a nicotinic acid receptor agonist in vitro.
How much does Dimethyl fumarate cost?
The cost of Dimethyl Fumarate is reasonable and one can readily purchase this medicine from any certified pharmaceutical supplier.