API- Cytarabine

Packaging- Single-use Vial

Strength- 100mg/500mg/1000mg

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Cytarabine (Cytosine Arabinoside or ara-C), specifically is a chemotherapy medication used for the treatment of acute myeloid leukemia (AML), acute lymphocytic leukemia (ALL), chronic myelogenous leukemia (CML), and non-Hodgkin’s lymphoma.

Dosage and Side Effects

The recommended cytarabine dose should be administered by infusion into a vein (through a drip) or by injection into a vein or by subcutaneous injection under the direction of your healthcare practitioner.
Your healthcare provider will determine what dose of cytarabine injection to administer and the number of days’ cytarabine treatment you will receive on behalf of your condition.

Most common adverse reactions include back pain, headache, confusion, arachnoiditis, weakness, abnormal gait, convulsions, pyrexia, constipation, fatigue, nausea and vomiting.

Warning and Precautions

  • Patients taking cytarabine treatment must be monitored closely.
  • The cytarabine uses are contraindicated in patients with hypersensitivity to it.
  • Women of childbearing potential with cytarabine injection are advised to avoid becoming pregnant.
  • Use the medication with caution and possibly at decreased dose in patients with poor liver/kidney function.
  • Periodic evaluations of bone marrow, liver/kidney functions need to be performed in patients with cytarabine 100 mg/500mg/1000mg injection.
  • Patients should stop breast-feeding prior to starting cytarabine therapy because it may be harmful to infants being breast-fed.
  • In patients with the reduced bone marrow, therapy with cytosine injection, must be started under precise medical supervision.


From which class of drug Cytarabine belongs?

Cytarabine (cytosar) specifically belongs to the class of drugs named antimetabolite and nucleoside analog. 

What are the alternate brands of Cytarabine Injection?

  • Biobin 500mg Injection (Cadila Healthcare Ltd)
  • Arasid 500mg Injection (Intas Pharmaceuticals Ltd) 
  • Remcyta 500mg Injection (Alkem Laboratories Ltd) 
  • Cytalon 500Mg Injection (Celon Laboratories Ltd) 

What are commonly reported side effects of cytarabine?

Liver problem, bone marrow suppression, rash, vomiting, diarrhea, bleeding and ulcer formation in the mouth are the common cytarabine side effects

How should Cytarabine be administered?

The recommended dose of cytarabine injection should be administered by injection into a vein, under the skin, or into the cerebrospinal fluid. 

How does Cytarabine work?

Cytosar is the cytarabine brand name, which works in order to block the function of DNA polymerase.