Treosulfan Injection

  • Medicine Name- Emtreo
  • API- Treosulfan
  • Packaging- 1 Vial
  • Strength- 5gm/Vial
  • Manufactured by- Emcure Pharma Ltd
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Description

Treosulfan 5 mg Injection in combination with fludarabine is used as part of conditioning treatment before allogeneic hematopoietic stem cell transplantation (alloHSCT) in adults and in pediatric patients older than one month with malignant and non-malignant diseases. 

Dosage and Side Effects

Adults with malignant disease: Treosulfan Injection is given along with fludarabine. The recommended dosage is 10 g/m² body surface area (BSA) per day as a two-hour intravenous infusion, given on three consecutive days (day -4, -3, -2) before stem cell infusion (day 0). The total treosulfan injection dose is 30 g/m². Fludarabine 30 mg/m² BSA daily as a 0.5-hour intravenous (IV) infusion, given on five consecutive days (day -6, -5, -4, -3, -2) before stem cell infusion (day 0). The total fludarabine dose is 150 mg/m². Treosulfan needs to be given before fludarabine on days -4, -3, -2.

Adults with non-malignant disease: Treosulfan injection is given in combination with fludarabine with or without thiotepa. The recommended dose is 14 g/m² body surface area (BSA) per day as a two-hour intravenous infusion, given on 3 consecutive days (day -6, -5, -4) before stem cell infusion (day 0). The total treosulfan dose is 42 g/m². Fludarabine 30 mg/m² BSA daily as a 0.5-hour intravenous (IV) infusion, given on five consecutive days (day -7, -6, -5, -4, -3) before stem cell infusion (day 0). The total fludarabine dose is 150 mg/m². Treosulfan needs to be given before fludarabine on days -6, -5, -4. Thiotepa 5 mg/kg twice daily, given as two intravenous (IV) infusions over 2 to 4 hours on day -2 before stem cell infusion (day 0). 

The most common side effects in adults and children with Treosulfan are infections, nausea (feeling sick), stomatitis (inflammation of the lining of the mouth), vomiting, diarrhea, tiredness, febrile neutropenia (low white blood cell counts with fever), high blood levels of bilirubin (a breakdown product of red blood cells), abdominal pain (belly ache), itching, and fever.

Warning and Precautions

  • Profound myelosuppression with pancytopenia is the desired therapeutic effect of treosulfan, occurring in all the respective patients. Frequently monitor blood cell counts until recovery of the hematopoietic system. 
  • Oral mucositis or OM (including high-grade severity) is an extremely common undesirable effect of treosulfan-based conditioning followed by alloHSCT. Use of mucositis prophylaxis (e.g. barrier protectants, topical antimicrobials, ice, and adequate oral hygiene) is recommended.
  • Treosulfan injection may impair fertility. Therefore, men taking treatment with treosulfan should not father a child during and up to six months after therapy and seek advice on cryo-conservation of sperm before therapy because of the potential of irreversible infertility due to treatment with treosulfan. Ovarian suppression and amenorrhoea with menopausal signs and symptoms occur in pre-menopausal patients.
  • Animal studies are not sufficient with respect to reproductive toxicity. The medicine Treosulfan is contraindicated during pregnancy. It is not specified whether this therapeutic drug is excreted in human milk. Breastfeeding needs to be discontinued while on therapy with treosulfan.

FAQ's

What is Treosulfan?

Treosulfan injection is a kind of chemotherapy. Individuals might have it as a treatment before a stem cell or bone marrow transplant.

How is Treosulfan administered

The recommended dosage of Treosulfan is administered as an intravenous infusion (IV) into the vein.

How much does Treosulfan cost in India?

Treosulfan 5 mg injection cost in India can vary. To procure this therapeutic drug legally, you can call us at (+91) 8130290915, TOLL-FREE: 1800-889-1064, Or Write us at info@indiangenericmedicines.com.

Can Treosulfan Injection be used while I’m pregnant?

Treosulfan injection may be unsafe if used during pregnancy. Talk to your clinician about the best way to help control your disease in case you want to become pregnant or during pregnancy. 

Can Treosulfan Injection be used while breastfeeding?

Breastfeeding is not recommended while on Treosulfan Injection. Talk to your clinician if you are breastfeeding or intend to breastfeed.

Where can I get Treosulfan Injection at the best Price? 

Order Treosulfan 5 mg Injection at the best price today. We request you to Call/WhatsApp us at (+91) 8130290915 or dial our TOLL-FREE Number: 1800-889-1064 or Write us at info@indiangenericmedicines.com. We are fully committed to providing you with the best Treosulfan Injection price in India. That is why we will match the cost/price of any other existing suppliers/distributors in the market who require a medical prescription.

Is the Treosulfan available in India?

Treosulfan is a (prescription drug, doctor-prescribed medication, or health care professional-prescribed medicine) pharmaceutical drug that can be legally dispensed against a medical prescription. Treosulfan can be made available through the network of authorized distributors in India. (Mumbai, Ahmedabad, Kolkata, Hyderabad, Bangalore, Chennai, Delhi, Pune, etc.)

Can You Send the Treosulfan to Foreign Destinations?

Buy Treosulfan online at the best/lowest price from a leading supplier. Indian Generic Medicines (IGM) can assist in the delivery of Treosulfan; the doctor-prescribed medication to the UK, Canada, Australia, China, South Africa, Philippines, the USA, Saudi Arabia, Thailand, Kazakhstan, Uzbekistan, Zambia, UAE, Sri Lanka, Pakistan, Kuwait, Sweden, Hong Kong, Turkey, Afghanistan, Malaysia, Singapore, Qatar, Japan, Nepal, and many other countries.

What is the procedure for buying Treosulfan from Indian Generic Medicines

Patients can fill out the order form or send mail to info@indiangenericmedicines.com. Patients can also send WhatsApp messages to +91 8130290915 or can dial the TOLL-FREE Number: 18008891064. We will reply ASAP with the details of the Treosulfan 5g price and procurement procedure.

Note:- The order will be confirmed only after the valid receipt of the prescription from the Physician.

Is it safe to buy Treosulfan (Emtreo) online from India?

Yes, one can buy Treosulfan (Emtreo 5 mg Injection) online from India-based Indian Generic Medicines if Treosulfan is not (yet) registered or is unavailable in their respective country. We can facilitate the supply/export of Treosulfan through legal channels.