Votrient-Pazopanib

  • Medicine Name- Votrient
  • API- Pazopanib
  • Packaging- Tablets
  • Strength- 200 mg
  • Manufactured by- Novartis
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Description

Pazopanib is a kinase inhibitor used for the treatment of adults with advanced renal cell carcinoma (RCC) and advanced soft tissue sarcoma (STS) who have previously been treated with chemotherapy.

Limitations of Use: The efficacy of Pazopanib for the treatment of patients with adipocytic soft tissue sarcoma or gastrointestinal stromal tumors (GISTs) has not been demonstrated.

Dosage and Side Effects

The recommended dosage of Pazopanib is 800 mg (four 200 mg tablets) orally once daily without food (at least 60 minutes before or 120 minutes after a meal) until there is evidence of disease progression or unacceptable toxicity. Swallow tablets whole. Do not crush tablets due to the potential for an increased rate of absorption, which may affect systemic exposure. The dosage needs to be modified for hepatic impairment and in those taking certain concomitant medicines. If a dose is missed, it need not be taken if it is < 12 hours until the very next dose.

The most common side effects of Pazopanib 200 mg tablets are

  • RCC: diarrhea, nausea, hypertension, hair color changes (depigmentation), anorexia, and vomiting. 
  • STS: fatigue, nausea, diarrhea, decreased weight, vomiting, hypertension, decreased appetite, headache, tumor pain, hair color changes, musculoskeletal pain, dyspnea, dysgeusia, and skin hypopigmentation.

Warning and Precautions

  • Serious and potentially life-threatening liver damage can occur. Regularly monitor liver function tests during Sorafenib treatment and as needed. If severe hepatotoxicity occurs, temporarily stop treatment and resume at a lower dose with weekly monitoring for 8 weeks. Alternatively, discontinue treatment permanently with weekly monitoring until hepatotoxicity resolves.
  • Regularly monitor patients at risk of QT interval prolongation. Conduct baseline and periodic electrocardiograms (ECGs) and electrolyte assessments. Correct any imbalances in potassium, magnesium, and calcium levels before starting and during Pazopanib 200 mg treatment.
  • Cardiac issues, such as reduced left ventricular ejection fraction (LVEF) and congestive heart failure, may arise with Pazopanib treatment. Monitor blood pressure and watch for signs of heart failure. Assess LVEF regularly in high-risk patients and adjust treatment accordingly. Consider withholding or discontinuing Pazopanib depending on the severity of cardiac dysfunction.
  • Venous thromboembolic events (VTEs), including potentially fatal pulmonary emboli (PE), have been noted. It is crucial to monitor for any indications or symptoms of VTE and PE. In the event of VTE occurrence, consider temporarily pausing Pazopanib treatment and then recommencing at the same dosage, or making the decision to discontinue treatment permanently based on the severity of the VTE. 
  • Severe infections, potentially leading to fatal outcomes, may arise, with or without neutropenia, during treatment with Pazopanib. Keep vigilant for any signs or symptoms of infection and initiate appropriate anti-infective treatment promptly. Consider temporarily halting or discontinuing Pazopanib therapy if necessary.

FAQ's

What is Pazopanib?

Pazopanib is a prescription medication used to treat advanced renal cell carcinoma (kidney cancer) and soft tissue sarcoma (cancer of soft tissues).

How should I take Pazopanib? 

Take Pazopanib orally with or without food as directed by your doctor, usually once daily. Follow your doctor’s instructions carefully.

How can I store Pazopanib?

Store Pazopanib at room temperature, away from moisture and heat, in its original container with the lid tightly closed.

How much does Pazopanib cost in India?

Pazopanib 200 mg cost in India is reasonable and can vary. To procure it legally, you can call us at (+91) 8130290915, TOLL-FREE: 1800-889-1064, Or Write us at info@indiangenericmedicines.com.

Can Pazopanib be used while I’m pregnant?

Pazopanib may be unsafe if used during pregnancy. Talk to your doctor about the best way to help control your disease if you want to become pregnant or during pregnancy. 

Can Pazopanib be used while breastfeeding?

Breastfeeding is not recommended while on Pazopanib. Talk to your doctor if you are breastfeeding or intend to breastfeed.

Where can I get Pazopanib at the best Price? 

Order Pazopanib at the best price today. We request you to Call/WhatsApp us at (+91) 8130290915 or dial our TOLL-FREE Number: 1800-889-1064 or Write us at info@indiangenericmedicines.com. We are fully committed to providing you with the best Pazopanib price from India. That is why we’ll match the cost/price of any other existing suppliers/distributors in the market who require a medical prescription.

Is Pazopanib available in India?

Pazopanib is a (prescription drug, doctor-prescribed medication, or health care professional-prescribed medicine) pharmaceutical drug that can be legally dispensed against a medical prescription. Pazopanib can be made available through the network of authorized distributors in India. (Mumbai, Ahmedabad, Kolkata, Hyderabad, Bangalore, Chennai, Delhi, Pune, etc.)

Can You Send the Pazopanib to Foreign Destinations?

Buy Pazopanib online at the best/lowest price from a leading supplier. Indian Generic Medicines (IGM) can assist in the delivery of Pazopanib; the doctor-prescribed medication to the UK, Canada, Australia, the USA, Philippines, China, Saudi Arabia, Thailand, South Africa, Kazakhstan, Zambia, Pakistan, Kuwait, Uzbekistan, Sri Lanka, Sweden, Hong Kong, UAE, Turkey, Afghanistan, Malaysia, Singapore, Qatar, Japan, Nepal, and many other countries.

What is the procedure to buy Pazopanib from Indian Generic Medicines

Patients can just fill out the order form or send mail to info@indiangenericmedicines.com. Patients can also send WhatsApp messages to +91 8130290915 or can dial the TOLL-FREE Number: 18008891064. We will reply ASAP with the details of the Pazopanib 200 mg price and the procurement procedure.

Note:- The order will be confirmed only after the valid receipt of the prescription from the Physician.

Is it safe to buy Pazopanib online from India?

Yes, one can buy Pazopanib 200 mg online from India-based Indian Generic Medicines if the medicine is not (yet) registered or is unavailable in their respective country. We can facilitate the supply of Pazopanib tablets through legal channels.