Nelarabine Injection

  • Medicine Name- Nelabin
  • API- Nelarabine 
  • Packaging- Single-Dose Vial
  • Strength- Injection; 250 mg/50 mL (5 mg/mL) 
  • Manufactured By- MSN Laboratories
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Description

Nelarabine injection is a nucleoside metabolic inhibitor used for the treatment of patients with T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoblastic lymphoma (T-LBL). This includes both adult and pediatric patients aged 1 year and older. It is specifically prescribed for individuals whose disease has not responded to or has relapsed following treatment with at least two chemotherapy regimens.

T-ALL and T-LBL are aggressive forms of cancer that originate in the T-cells, which are a type of white blood cell essential for the immune system. These conditions require timely and effective treatment to manage the rapid proliferation of cancerous cells. Nelarabine works as a prodrug that is converted into an active compound within the body, targeting and killing cancerous cells. This mechanism of action provides a targeted approach to destroy malignant T-cells while aiming to minimize damage to healthy cells.

For patients who have exhausted other treatment options, the therapeutic drug Nelarabine injection offers a crucial opportunity for disease management and potential remission.

Dosage and Side Effects of Nelarabine injection

Adults and adolescents (aged 16 years and older): The recommended dose of Nelarabine for adults and adolescents aged 16 years and older is 1,500 mg/m². This dosage is administered intravenously over two hours on days 1, 3, and 5 of the treatment cycle. The cycle is repeated every 21 days. This regimen is designed to ensure the optimal therapeutic effect while managing the side effects associated with the medication.

Children and adolescents (aged 21 years and younger): The recommended dose of Nelarabine injection (250 mg/50 mL, 5 mg/mL) for children and adolescents (aged 21 years and younger) is 650 mg/m². It is administered intravenously over one hour daily for five consecutive days, and this regimen is repeated every 21 days. This dosing schedule is designed to maximize the therapeutic effect while managing potential side effects, ensuring effective treatment for young patients with specific medical conditions. 

The most common side effects of Nelarabine 250 mg/50 mL injection are drowsiness (for several days after injection); nausea, vomiting, diarrhea, constipation; numbness or tingling; headache, tiredness; and blurred vision.

Warning and Precautions

  • Patients receiving nelarabine may experience neurological adverse reactions, including seizures, peripheral neuropathy, and confusion. Monitor patients closely for these symptoms during treatment. Adjust dosage or discontinue treatment if severe neurological symptoms occur.
  • Avoid live organism vaccines during treatment with nelarabine due to the potential for reduced efficacy and risk of infection. Vaccination schedules should be discussed with healthcare providers before starting treatment to ensure optimal immunization without compromising patient safety.
  • Nelarabine injection can cause severe hematologic adverse reactions such as neutropenia, thrombocytopenia, and anemia. Monitor blood counts regularly before and during treatment. Consider dose modifications or supportive care measures based on hematologic parameters to minimize the risk of complications.
  • Patients receiving nelarabine are at risk of developing tumor lysis syndrome (TLS), characterized by metabolic abnormalities such as hyperuricemia, hyperkalemia, hyperphosphatemia, and hypocalcemia. Monitor electrolyte levels closely and initiate preventive measures, including hydration and allopurinol, as appropriate.
  • Nelarabine can cause embryo-fetal toxicity based on animal studies and its mechanism of action. Advise patients of childbearing potential to use effective contraception during treatment and for a period afterward. Consider pregnancy testing before starting therapy and provide counseling on the potential risks to the fetus.

FAQ's

What is Nelabin?

Nelabin is a generic brand of medicine containing Nelarabine as its active ingredient. It is primarily used in the treatment of T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoblastic lymphoma (T-LBL).

How should I take Nelarabine? 

Nelarabine is typically taken intravenously (IV) over 1 to 2 hours. The dosage depends on body weight and medical condition. Follow your doctor’s instructions appropriately for desired results.

How can I store Nelarabine?

Store Nelarabine at room temperature between 20-25°C (68-77°F). Protect from light and moisture. Keep it in its original packaging and out of reach of children and pets.

How much does Nelarabine cost in India?

The cost of Nelarabine in India varies depending on the supplier and dosage. For accurate pricing and procuring Nelarabine legally, one can call us at (+91) 8130290915, TOLL-FREE: 1800-889-1064, Or Write us at info@indiangenericmedicines.com.

Can Nelarabine be used while I’m pregnant?

Nelarabine may be unsafe if considered during pregnancy. Talk to your doctor about the best way to help control your condition if you want to become pregnant or during pregnancy. 

Can Nelarabine be used while breastfeeding?

Breastfeeding is not recommended while on Nelarabine. Talk to your doctor if you are breastfeeding or intend to breastfeed.

Where can I get Nelarabine at the best Price? 

Order Nelarabine at the best price today. We request you to Call/WhatsApp us at (+91) 8130290915 or dial our TOLL-FREE Number: 1800-889-1064 or Write us at info@indiangenericmedicines.com. We are fully committed to providing you with the best Nelarabine price from India. That is why we’ll match the cost/price of any other existing suppliers/distributors in the market who require a medical prescription.

Is the Nelarabine available in India?

Nelarabine is a (prescription drug, doctor-prescribed medication, or health care professional-prescribed medicine) pharmaceutical drug that can be legally dispensed against a medical prescription. Nelarabine can be made available through the network of authorized distributors in India. (Bangalore, Ahmedabad, Mumbai, Kolkata, Hyderabad, Chennai, Delhi, Pune, etc.).

Can You Send the Nelarabine to Foreign Destinations?

Buy generic Nelarabine online at the best/lowest price from a leading supplier. Indian Generic Medicines (IGM) can assist in the delivery of Nelarabine; the doctor-prescribed medication to the UK, Canada, UAE, Australia, Philippines, the USA, Saudi Arabia, Thailand, China, South Africa, Kazakhstan, Uzbekistan, Hong Kong, Zambia, Pakistan, Kuwait, Sweden, Turkey, Afghanistan, Malaysia, Singapore, Qatar, Japan, Nepal, Sri Lanka, and many other countries.

What is the procedure to buy Nelarabine from Indian Generic Medicines

Patients can simply fill out the order form or send mail to info@indiangenericmedicines.com. Patients can also send WhatsApp messages to +91 8130290915 or can dial the TOLL-FREE Number: 18008891064. We will reply ASAP with the details of the Nelarabine 250 mg/50 mL price and the procurement procedure.

Note:- The order will be confirmed only after the valid receipt of the prescription from the Physician.

Is it safe to buy Nelarabine online from India?

Yes, one can buy Nelarabine 250 mg/50 mL injection online from India-based Indian Generic Medicines (IGM) if the medication is not (yet) registered or is unavailable in the respective country. We can facilitate the supply of Nelarabine through legal channels.