Bosutinib is a kinase inhibitor used for the treatment of adult and pediatric patients aged 12 months and older with chronic phase (CP) Ph+ chronic myelogenous leukemia (CML), newly-diagnosed or resistant or intolerant to prior therapy. This therapeutic drug is also used for the treatment of adult patients with accelerated, or blast phase (BP) Ph+ chronic myelogenous leukemia (CML) with resistance or intolerance to prior therapy.
The recommended dose of Bosutinib tablets is taken by mouth (orally) once daily with food. The tablet is to be swallowed as a whole and should not be either broken or chewed. Continue treatment with this drug until the disease is progressive or intolerant to therapy.
Adult Patients with Newly-Diagnosed CP Ph+ CML: The recommended dosage is 400 mg orally once daily with food.
Adult Patients with CP, AP, or BP Ph+ CML with Resistance or Intolerance to Prior Therapy: The recommended dosage is 500 mg orally once daily with food.
Pediatric Patients with Newly-Diagnosed CP Ph+ CML or with CP Ph+ CML with Resistance or Intolerance to Prior Therapy: The recommended dosage of Bosutinib for pediatric patients with newly-diagnosed CP Ph+ CML is 300 mg/m2 orally once daily with food and the recommended dosage for pediatric patients with CP Ph+ CML that is resistant or intolerant to prior therapy is 400 mg/m2 orally once daily with food.
The most common side effects of Bosutinib in adult and pediatric patients with CML are abdominal pain, diarrhea, vomiting, fatigue, hepatic dysfunction, headache, pyrexia, decreased appetite respiratory tract infection, nausea, rash, and constipation.
Vomiting, diarrhea, nausea, and abdominal pain occur with Bosutinib treatment. Monitor and manage patients using standards of care (SOC), including antiemetics, antidiarrheals, and fluid replacement.
Neutropenia, thrombocytopenia, and anemia occur with Bosutinib treatment. Perform complete blood counts (CBCs) weekly for the opening month of therapy and then monthly afterward, or as clinically suggested. To cope with myelosuppression, withhold, dose reduce, or discontinue treatment as required.
Bosutinib 500 mg may cause elevations in serum transaminases (alanine aminotransferase or ALT, aspartate aminotransferase or AST). Do hepatic enzyme tests monthly for the initial three months of treatment and as clinically needed. In those with transaminase elevations, monitor liver enzymes more often. Withhold, dose reduce, or discontinue as required.
Fluid retention may occur with Bosutinib 100mg/400mg/500mg therapy and may manifest as pleural effusion, pericardial effusion, and pulmonary/peripheral edema. Monitor as well as manage patients using standards of care (SOC). Interrupt, dose reduce or discontinue treatment with Bosutinib 100 mg as necessary.
Findings from animal studies and its mechanism of action, Bosutinib can cause fetal harm when used by a pregnant woman. Females of reproductive ability should use effective contraception throughout the treatment and for at least a couple of weeks after the final dose of Bosutinib tablets.
No information exists regarding the presence of Bosutinib 500mg/400mg/100mg in human milk or its probable effects on a breastfed child. Because of the possibility of significant adverse reactions in a nursing child, breastfeeding is not recommended during treatment and for at least 2 weeks after the last dose.
What is Bosutinib?
Bosutinib is formulated as a small molecule BCR-ABL and tyrosine kinase inhibitor (TKI) used for patients with chronic myelogenous leukemia (CML).
What dosage strengths Bosutinib tablets are supplied?
Bosutinib tablets are supplied for oral administration in three different dosage strengths, which are as follows:
How do I take Bosutinib?Â
Bosutinib is available as a tablet to take by mouth. This medicine is typically taken with food once daily.Â
How do I store Bosutinib?Â
Store the tablets at 20-25°C (68-77°F); excursions permitted to 15-30°C (59-86°F). Store and dispense it in the original container.
How much does Bosutinib cost in India?
Bosutinib tablet cost in India is very reasonable and can vary. To procure it legally, you can call us at (+91) 8130290915, TOLL-FREE: 1800-889-1064, Or Write us at info@indiangenericmedicines.com.
Where can I get Bosutinib at the best Price?Â
Order Bosutinib at the best price today. We request you to Call/WhatsApp us at (+91) 8130290915 or dial our TOLL-FREE Number: 1800-889-1064 or Write us at info@indiangenericmedicines.com. We’re fully committed to providing you with the best Bosutinib price from India. That is why we’ll match the cost/price of any other existing suppliers/distributors in the market who require a medical prescription.
Is Bosutinib available in India?
Bosutinib is a (prescription drug, doctor-prescribed medication, or health care professional-prescribed medicine) pharmaceutical drug that can be legally dispensed against a medical prescription. Bosutinib can be made available through the network of authorized distributors in India. (Mumbai, Ahmedabad, Kolkata, Hyderabad, Bangalore, Chennai, Delhi, Pune, etc.).Â
Can You Send the Bosutinib to Foreign Destinations?
Buy generic Bosutinib online at the best/lowest price from a leading supplier. Indian Generic Medicines can assist in the delivery of Bosutinib; the doctor-prescribed medication to the UK, Canada, Australia, Philippines, the USA, Saudi Arabia, Thailand, China, South Africa, Kazakhstan, Uzbekistan, Afghanistan, Pakistan, Kuwait, Sri Lanka, Sweden, Hong kong, UAE, Zambia, Turkey, Malaysia, Singapore, Qatar, Japan, Nepal, and many other countries.
What is the procedure to buy Bosutinib from Indian Generic Medicines?Â
Patients can fill out the order form or send mail to info@indiangenericmedicines.com. Patients can also send WhatsApp messages to +91 8130290915 or can dial the TOLL-FREE Number: 18008891064. We will reply ASAP with the details of the Bosutinib 100mg/400mg/500mg price and the procurement procedure.
Note:- The order will be confirmed only after the valid receipt of the prescription from the Physician.
Is it safe to buy Bosutinib Tablets online from India?
Yes, one can buy Bosutinib tablets online from India-based Indian Generic Medicines if this medicine is not (yet) registered or is unavailable in their respective country. We can facilitate the export of generic Bosutinib through legal channels.
The Indian Generic Medicines is a Consultancy and Service company providing access to genuine generic medicines to patients all across the world. We also have own pharmacy named as Indian Generic Medicines which work under compliant distribution guidelines.
© 2024 Indian Generic Medicines. All rights reserved.
