The recommended dose of Bosutinib tablets is taken by mouth (orally) once daily with food. The tablet is to be swallowed as a whole and should not be either broken or cut. Continue treatment with this medicine (Bosutinib) until the disease is progressive or intolerant to therapy.
- Newly-Diagnosed CP Ph+ CML: The recommended dose of Bosutinib is 400 mg taken orally once daily with food.
- CP, AP, or BP Ph+ CML with Resistance or Intolerance to Prior Therapy: The recommended dose and schedule of Bosutinib is 500 mg taken orally once daily with food.
If a dose of Bosutinib is missed/skipped beyond 12 hours, the patient should skip the dose and take the usual prescribed dose on the following day.
Consider dose escalation by increments of 100 mg once a day to a maximum of 600 mg daily in all those who do not reach full hematologic, cytogenetic, or molecular response and do not have Grade three or greater side effects.
The most commonly reported Bosutinib side effects in patients with CML are diarrhea, rash, vomiting, fatigue, nausea, abdominal pain, hepatic dysfunction, pyrexia, respiratory tract infection, and headache.