Darzalex

  • Medicine Name- Darzalex
  • API- Daratumumab
  • Packaging- Single-dose vial
  • Strength- 100 mg/5 mL and 400 mg/20 mL
  • Manufactured by: Janssen Pharmaceuticals
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Description

Daratumumab (Darzalex) injection is a CD38-directed cytolytic antibody widely used for the treatment of adult patients with  a type of blood cancer known as multiple myeloma (MM):

    • In combination with drugs lenalidomide (D-Rd) and dexamethasone in newly diagnosed patients who are not eligible for autologous stem cell transplant (ASCT) and in patients with relapsed or refractory multiple myeloma (MM) who have previously been treated with at least one therapy
    • In combination with drugs bortezomib, melphalan, and prednisone (D-VMP) in newly diagnosed patients who are not eligible for autologous stem cell transplant (ASCT)
    • In combination with medicines bortezomib, thalidomide, and dexamethasone (D-VTd) in newly diagnosed patients who are eligible for autologous stem cell transplant (ASCT)
    • In combination with medicines bortezomib and dexamethasone in patients who have received at least one prior therapy
    • In combination with therapeutic drugs carfilzomib and dexamethasone in patients with relapsed or refractory multiple myeloma (RRMM) who have been treated with 1 to 3 prior lines of therapy
    • In combination with medicines pomalidomide (D-Pd) and dexamethasone in patients who have previously been treated with at least a couple of treatments including lenalidomide (D-Rd) and a proteasome inhibitor (PI)
    • As monotherapy, in patients who have been treated with at least three prior lines of treatment including a PI and an immunomodulatory agent, or who are double-refractory to a proteasome inhibitor (PI) and an immunomodulatory agent.

Dosage and Side Effects of Darzalex Injection

The recommended dose of Daratumumab injection is 16 mg/kg actual body weight administered (in combination with other medications) as an intravenous (IV) infusion. Pre-medicate with corticosteroids, antipyretics, and antihistamines. Administer post-infusion medications.

The most common side effects of Darzalex injection are infusion-related reactions, cough, upper respiratory infection, peripheral edema, neutropenia, constipation, thrombocytopenia, diarrhea, anemia, peripheral sensory neuropathy, dyspnea, fatigue, pyrexia, nausea, and asthenia.

Warning and Precautions

  • Daratumumab injection can cause serious IRRs including anaphylactic reactions. Pre-medicate patients with antipyretics, antihistamines, and corticosteroids. Monitor patients throughout the infusion. Interrupt infusion for reactions of any severity and institute medical management as required. Permanently stop therapy if an anaphylactic reaction or critical (Grade 4) reaction occurs and institute apt emergency care.
  • Daratumumab 100 mg/5 mL or 400 mg/20 mL may be responsible for increased neutropenia induced by background therapy. Monitor complete blood cell counts periodically throughout therapy as per the manufacturer’s PI for background therapies. Assess patients with neutropenia for signs and symptoms of infection. Consider withholding treatment until the full recovery of neutrophils.
  • Treatment with Daratumumab injection may increase thrombocytopenia induced by background therapy. Monitor complete blood cell counts (CBC) periodically throughout treatment according to the manufacturer’s PI for background therapies. Consider withholding this treatment until the full recovery of platelets. 
  • Based on the mechanism of action, the medicine Daratumumab can cause fetal harm if given to a pregnant woman. It may cause depletion of fetal immune cells and scaled-down bone density. Females of reproductive age must use suitable contraception during treatment and for 3 months after the last dose.

FAQ's

What is Daratumumab?

Daratumumab injection is a cancer therapeutic drug used to treat adults with multiple myeloma (a cancer of the bone marrow).

How is Daratumumab used

The recommended dosage of Daratumumab injection is given by infusion (drip) into a vein or by injection under the skin. 

How to store Daratumumab?

Store this medicinal product in a refrigerator at 2-8°C (36-46°F). Never freeze or shake it. Protect it from the light.

How much does Daratumumab cost in India?

Daratumumab injection cost in India is very reasonable and can vary. To procure this CD38-directed cytolytic antibody legally, you can call us at (+91) 8130290915, TOLL-FREE: 1800-889-1064, Or Write us at info@indiangenericmedicines.com.

Can Daratumumab be used while I’m pregnant?

Daratumumab injection may be unsafe if used by pregnant females. They should talk to their clinician about the best way to manage their disease if they intend to become pregnant or during pregnancy. 

Can Daratumumab be used while breastfeeding?

Do not breastfeed while on Daratumumab treatment. Talk to your clinician if you are breastfeeding or intend to breastfeed.

Where can I get Daratumumab at the best Price? 

Order Daratumumab injection at the best price today. We request you to Call/WhatsApp us at (+91) 8130290915, dial our TOLL-FREE Number: 1800-889-1064, or Write us at info@indiangenericmedicines.com. We’re fully committed to providing you with the best Daratumumab price from India. That is why we’ll match the cost/price of any other suppliers/facilitators/distributors in the market who require a valid medical prescription.

Is Daratumumab available in India?

Daratumumab injection is a (prescription drug, health care professional-prescribed medicine, or doctor-prescribed medication) pharmaceutical drug that can be legally dispensed against a valid medical prescription. Daratumumab can be made available through the network of authorized distributors in India. (Mumbai, Delhi, Ahmedabad, Hyderabad, Kolkata, Bangalore, Chennai, Pune, etc.)

Can You Send the Daratumumab to a Foreign Destination?

Buy Daratumumab injection online at the best/lowest price from a leading supplier. Indian Generic Medicines can assist in the delivery of Daratumumab; the doctor-prescribed medication to the UK, Canada, Philippines, Australia, the USA, South Africa, Saudi Arabia, Thailand, China, Kazakhstan, Uzbekistan, Zambia, Pakistan, UAE, Kuwait, Sweden, Turkey, Afghanistan, Malaysia, Singapore, Qatar, Japan, Hong Kong, Nepal, Sri Lanka, and many other countries.

What is the procedure to buy Daratumumab from Indian Generic Medicines

Patients can just fill out the order form or send mail to info@indiangenericmedicines.com. Patients can also send WhatsApp messages to +91 8130290915 or can dial the TOLL-FREE Number: 18008891064. We will reply ASAP with the details of the Daratumumab 400 mg/20 mL injection price as well as the procurement procedure.

Note:- The order will be confirmed only after the valid receipt of the prescription from the Physician.

Is it safe to buy Daratumumab online from India?

Yes, one can buy Daratumumab injection online from India-based Indian Generic Medicines (IGM) if it is not (yet) registered or is available in their respective country. We can facilitate the supply/export of Daratumumab through legal channels.