In case a dose of cefazolin injection is needed that does not equal 1 gram or 2 grams, this product is not recommended for use and as an alternative formulation of cefazolin should be considered. Cefazolin injection is for intravenous use only over approximately 30 minutes.
Standard Dosing Schedule in Adults with CLcr Higher Than or Equal To 55 mL per min:
- For moderate to severe infections: cefazolin 500 mg to 1 gram, given every 6 to 8 hours.
- For mild infections caused by susceptible gram-positive cocci: cefazolin 250 mg to 500 mg, given every 8 hours.
- Acute, uncomplicated urinary tract infections: 1 gram, given every 12 hours.
- Pneumococcal pneumonia: cefazolin 500 mg, given every 12 hours.
Severe, life-threatening infections (e.g., endocarditis, septicemia): cefazolin 1 gram to 1.5 grams, given every 6 hours.
- Perioperative prophylaxis: cefazolin 1 gram to 2 grams (given ½ to 1 hour prior to start of surgery), cefazolin 500 mg to 1 gram (given during surgery for lengthy procedures), cefazolin 500 mg to 1 gram (given every 6 to 8 hours for 24 hours postoperatively).
Standard Dosing Schedule in Pediatrics with CLcr Higher than or Equal to 70 mL per min:
- For moderate to severe infections: cefazolin 25 to 50 mg per kg, given in 3 or 4 equally divided doses.
- For severe infections: a dosage of cefazolin may increase to 100 mg per kg, given in 3 or 4 equally divided doses.
The most commonly reported side effects due to cefazolin iv injection include: gastrointestinal (nausea, vomiting, diarrhea), and allergic reactions (skin rash, anaphylaxis, urticaria).