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Pomalidomide

  • Medicine name- Pomalid
  • API- Pomalidomide
  • Packaging- 21 Capsules
  • Strength- 1 mg, 2 mg & 4 mg
  • Manufactured By: Natco Pharma Ltd
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Description

Pomalidomide is used for two main conditions in adults:

  • Treating Multiple Myeloma (MM):
    • Given with dexamethasone after at least two prior treatments, including lenalidomide and a proteasome inhibitor, for those whose disease got worse despite previous therapies.
  • Addressing AIDS-Related Kaposi Sarcoma (KS):
    • Used when standard HIV treatments fail for AIDS-related KS. Also considered for KS in HIV-negative patients, but more evidence is needed from additional studies.

Dosage and Side Effects

  • For Multiple Myeloma (MM):
    • Take a Pomalidomide 4 mg capsule once daily for 21 days in a 28-day cycle until the disease worsens.
    • Follow specific guidelines for taking dexamethasone along with Pomalidomide.
  • For Kaposi Sarcoma (KS):
    • Take a 5 mg capsule once daily for 21 days in a 28-day cycle until the disease worsens or if there are side effects.
  • Adjustments:
    • Doctors might change the dose for patients with kidney or liver issues.
  • For Multiple Myeloma (MM): The most common side effects include tiredness, weakness, low white blood cells, low red blood cells, constipation, nausea, diarrhea, breathing problems, infections, back pain, and fever.
  • For Kaposi Sarcoma (KS): Common side effects include changes in blood counts, kidney function, skin rash, constipation, tiredness, low red blood cells, low platelets, low phosphate, low albumin, high liver enzymes, nausea, and diarrhea.

Warning and Precautions

  • When combining pembrolizumab with dexamethasone and a thalidomide-like drug for multiple myeloma, higher mortality rates were noted.
  • Hematologic toxicity, particularly neutropenia, requires close patient monitoring.
  • Hepatotoxicity resulting in liver failure, albeit rare, necessitates monthly liver function tests.
  • Immediate discontinuation of Pomalidomide is crucial if severe skin reactions occur.
  • Patients with a high tumor burden should be closely monitored for Tumor Lysis Syndrome (TLS) and preventative measures taken.
  • Regular monitoring for potential hypersensitivity reactions, with prompt discontinuation if angioedema or anaphylaxis arises.

FAQ's

Is pomalidomide FDA approved?

FDA approves Pomalidomide for advanced multiple myeloma.

Is pomalidomide classified as a steroid?

Pomalidomide is a class of targeted cancer medication. Another name for it is Imnovid. A steroid is dexamethasone. This treatment is for patients whose myeloma has relapsed or grown worse (refractory) after receiving treatment.

What is Pomalidomide used for?

It’s primarily used in adults for two main conditions: treating Multiple Myeloma (MM) in combination with dexamethasone after at least two prior treatments, and addressing AIDS-Related Kaposi Sarcoma (KS) when standard HIV treatments aren’t effective.

Are there any warnings or precautions to consider when using Pomalidomide capsules?

  • Yes, when combining certain medications with Pomalidomide for MM, higher mortality rates were noted.
  • Close monitoring for blood-related issues like neutropenia and liver function tests monthly is recommended due to rare instances of liver failure.
  • Immediate discontinuation is advised if severe skin reactions occur, and monitoring for tumor-related syndrome and potential hypersensitivity reactions is crucial

Is pomalidomide oral or IV?

The drug, a capsule taken by mouth, belongs to a class of medications called immunomodulating agents.

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