Clofarabine

  • Medicine Name- Farabine
  • API- Clofarabine
  • Packaging- Single-use flint vials
  • Strength- 20 mg/20 mL (1 mg/mL) 
  • Manufactured by: Intas Pharmaceuticals Ltd.
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Description

Clofarabine 20mg injection is a nucleoside metabolic inhibitor available as a powder for injections generically and under the brand name Farabine. It is approved for use as an antineoplastic agent for the treatment of pediatric patients aged 1 to 21 years with relapsed or refractory acute lymphoblastic leukemia (ALL) after at least a couple of prior regimens.


Dosage and Side Effects of Clofarabine Injection:

The recommended pediatric dose for ALL is 52 mg/m2 administered as an intravenous (IV) infusion over 2 hours once daily for 5 consecutive days of a 28-day cycle, with repeat courses every 2-6 weeks. Provide supportive care, such as anti-hyperuricemic treatment, intravenous (IV) infusion fluids, and alkalinization of urine throughout the 5 days of Clofarabine administration to scale down the probability of tumor lysis and other adverse reactions. Discontinue treatment in case hypotension develops during the five days of administration.

The most common side effects of Clofarabine are headache, vomiting, pain in extremity, nausea, fatigue, diarrhea, abdominal pain, febrile neutropenia, pruritus, bacteremia, pyrexia, rash, tachycardia, anorexia, chills, hypotension, and petechiae.


Warning and Precautions of Clofarabine Injection:

  • Treatment with Clofarabine results in myelosuppression which may be serious and prolonged. Myelosuppression is reversible with interruption of Clofarabine treatment and appears to be dose-dependent. Monitor complete blood counts (CBC).
  • Critical hemorrhage, including cerebral, gastrointestinal, and pulmonary hemorrhage may occur. The maximum number of cases were associated with thrombocytopenia. Evaluate platelets and coagulation parameters and treat patients accordingly.
  • This medicinal product increases the probability of infection, including serious and fatal sepsis, and opportunistic infections. Monitor all the patients for signs and symptoms of infection, stop treatment, and treat them promptly.
  • Use of Farabine 20 mg/20 mL may cause tumor lysis syndrome (TLS) linked with the break-down metabolic products from peripheral leukemia cell death. Monitor patients for signs/ symptoms of tumor lysis syndrome (TLS) and start preventive measures including adequate intravenous (IV) fluids and measures to manage uric acid.
  • Farabine may be responsible for causing a cytokine release syndrome (tachycardia, tachypnea, hypotension, pulmonary edema) that may progress to the SIRS with capillary leak syndrome and organ impairment which may be fatal. Monitor patients a bit frequently for such conditions.
  • Those who have previously received an HSCT are at greater risk for veno-occlusive disease (VOD) of the liver after treatment with clofarabine when used along with etoposide (100 mg/m2 ) and cyclophosphamide (440 mg/m2). Monitor for and discontinue treatment if VOD is suspected.  
  • Serious and fatal hepatotoxicity, including hepatitis and hepatic failure may occur with the use of this medication. Monitor hepatic function and for signs and symptoms of hepatitis and hepatic failure. Stop treatment quickly for Grade 3 or higher liver enzyme and/or bilirubin elevations.
  • Fatal and severe cases of enterocolitis, including cecitis, neutropenic colitis, and C difficile colitis, may occur during treatment with clofarabine 20 mg/20 mL. Enterocolitis may cause perforation, necrosis, hemorrhage, or sepsis complications. Monitor all the patients for signs and symptoms of enterocolitis and treat them quickly.

FAQ's

What is Clofarabine Injection?

Clofarabine Injection is an antineoplastic agent and purine analogue widely used in the therapy of children with acute lymphoblastic leukemia (ALL).

How is Clofarabine typically given/administered? 

The recommended dosage of Clofarabine 20 mg/20 mL Injection may be administered intravenously (into a vein).  

How to store Clofarabine?

Vials that contain undiluted Clofarabine Injection need to be stored at 25°C (77°F); excursions permitted to 15 to 30°C (59 to 86°F). Never freeze it. Retain the same carton until the contents are used. 

How much does Clofarabine cost in India?

Clofarabine Injection cost in India is very reasonable and can vary. To procure this therapeutic drug legally, you can call us at (+91) 8130290915, TOLL-FREE: 1800-889-1064, Or Write us at info@indiangenericmedicines.com.

Can Clofarabine be used while I’m pregnant?

Clofarabine Injection may be not safe if used during pregnancy. Discuss with your healthcare professional about the best way to control your disease if you intend to become pregnant or during pregnancy. 

Can Clofarabine be used while breastfeeding?

Breastfeeding is not recommended while on treatment with Clofarabine Injection. Discuss with your doctor if you are breastfeeding or want to breastfeed.

Where can I get Clofarabine injections at the best Price? 

Order Clofarabine Injection at the best price today. We request you to Call/WhatsApp us at (+91) 8130290915, dial our TOLL-FREE Number: 1800-889-1064 or Write us at info@indiangenericmedicines.com. We’re committed to providing you with the best Clofarabine 20 mg/20 mL price from India. That is why we’ll match the price/cost of any other exporters/suppliers/distributors in the market who need a medical prescription.

Is Clofarabine available in India?

Clofarabine Injection is a (prescription drug, doctor-prescribed medication, or health care professional-prescribed medicine) therapeutic drug that can be legally dispensed against a medical prescription. Clofarabine can be made available through the wide network of authorized distributors in India. (Mumbai, Ahmedabad, Hyderabad, Kolkata, Bangalore, Delhi, Chennai, Pune, etc.)

Can You Send the Clofarabine to a Foreign Destination?

Buy Clofarabine Injection online at the best/lowest price from a leading supplier. Indian Generic Medicines (IGM) can assist in the delivery of Clofarabine; the doctor-prescribed medication to the UK, Australia, Canada, Philippines, Saudi Arabia, Sweden, Thailand, South Africa, Kazakhstan, China, Uzbekistan, Afghanistan, Zambia, Sri Lanka, Pakistan, Kuwait, Hong Kong, UAE, Turkey, Malaysia, Singapore, Qatar, Japan, Nepal, the USA, and many other countries.

What is the procedure to buy Clofarabine from Indian Generic Medicines

Patients can simply fill out the order form or send mail to info@indiangenericmedicines.com. Patients can also send WhatsApp messages to +91 8130290915 or can dial the TOLL-FREE Number: 18008891064. We will reply ASAP with the details of the Clofarabine price and the procurement procedure.

Note:- The order will be confirmed only after the valid receipt of the prescription from the Physician.

Is it safe to buy Clofarabine (Farabine) online from India?

Yes, one can buy Clofarabine (Farabine) Injection online from India-based Indian Generic Medicines (IGM) if it is not (yet) registered or is unavailable in your respective country. We can facilitate the export of Farabine through legal channels.