Cloxacillin Sodium

Warning and Precautions

• During the long-term therapy with cloxacillin antibiotic, hepatic, renal and hematopoietic functions needs to be checked periodically.
• Severe and sometimes fatal hypersensitivity (anaphylactoid) reactions have been observed in such patients who recieving cephalosporin or penicillin therapy.
• Watchful inquiry should be made concerning prior hypersensitivity to reactions to penicillins, cephalosporins or certain other allergens.
• During treatment with cloxacillin generic, in case allergic or anaphylactic reactions occur, interrupt treatment and administer the usual agents, e.g. pressor amines, antihistamines, corticosteroids.
• The passage of any penicillin from blood into the brain is facilitated by inflamed meninges and during cardiopulmonary bypass. In the existence of such factors, mainly in renal failure when high serum concentration can be attained, CNS side effects including convulsive seizures, myoclonia and depressed consciousness can be expected.
• During long-term therapy with cloxacillin 10g or with any other dosage strength, renal, hepatic and hematopoietic functions needs to be checked periodically.
• Candidiasis and some other superinfections may emerge, mainy in debilitated and malnourished patients, or those with low resistance to infection due to immunosuppressors, corticosteroids or irradiation. If superinfection apears, institute apt measures.