Fulvestrant-250

Fulvestrant

API- Fulvestrant

Packaging- 2×5ml

Strength-  250mg/5ml

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Description

Fulvestrant is an estrogen receptor antagonist used for the treatment of:

  • HR +Ve metastatic breast cancer in the postmenopausal women with disease progression.
  • HR +Ve, HER2 -Ve advanced breast cancer along with palbociclib in women with disease progression after the therapy of endocrine.

Dosage and Side Effects

The recommended fulvestrant dose is 500 mg, should be administered intramuscularly into the buttocks slowly (1 to 2 minutes per injection) as two 5 mL injections, one in each buttock, on the days 1’st, 15’th, 29’th and once monthly thereafter.

Most common adverse reactions include bone pain, hot flash, musculoskeletal pain, nausea, arthralgia, injection site pain, headache, pain in extremity, cough, vomiting, constipation, back pain, fatigue, anorexia, asthenia, and dyspnea.

Warning and Precautions

  • The fulvestrant uses are normally contraindicated in patients with the known hypersensitivity to it or any of its existing components.
  • The faslodex 250 injection should be used with caution in patients with thrombocytopenia, bleeding diathesis, or anticoagulant use.
  • Caution should be imposed while administering faslodex at the dorsogluteal injection site due to the proximity of the underlying sciatic nerve.
  • A fulvestrant 250 mg dose is recommended in patients with the moderate hepatic impairment.
  • Women must be apprised of the potential hazard to the fetus and to avoid becoming pregnant while on Faslodex.
  • Breastfeeding is restricted while on the therapy with fulvestrant 250 mg.

FAQ's

From which class of drug Fulvestrant belongs?

Fulvestrant specifically belongs to the class of drugs named estrogen receptor antagonists. 

What are the alternate brands of Fulvestrant Injection?

  • Fulvenat 250mg InjectionInjection (Natco Pharma Ltd) 
  • Fulvetraz 250mg Injection (Alkem Laboratories Ltd) 
  • Strantas Injection (Intas Pharmaceuticals Ltd) 
  • Fuvestrol 250mg Injection (Cadila Pharmaceuticals Ltd) 
  • Fulviglen 250mg Injection (Glenmark Pharmaceuticals Ltd) 
  • Fasnorm 250mg Injection (Biocon Ltd) 
  • Celvestrant 250mg Injection (Celon Laboratories Ltd)

What are commonly reported side effects of Fulvestrant?

Hypersensitivity reactions, hot flushes, urinary tract infections, loss of appetite, blood clots in veins, headache, vomiting, diarrhea, elevated bilirubin, back pain and rashes are the common fulvestrant side effects. 

How should Fulvestrant be administered?

The recommended dose of fulvestrant injection should be administered by injection into a muscle.

How does Fulvestrant work?

As a SERD (Selective Estrogen Receptor Degrader), fulvestrant works in order to bind to the estrogen receptor and destabilize it, causing the cell’s protein degradation actions to kill it.

How much does faslodex cost?

The average wholesale fulvestrant injection price in India for 50 mg/mL is around 146,448 INR for a supply of 10 milliliters.

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