Bortezomib Injection

Bortezomib 2mg & 3.5mg Injection

  • Medicine Name- Bortenat
  • API- Bortezomib
  • Packaging- 10 mL single-dose vial
  • Strength- 2mg/vial & 3.5mg/vial
  • Manufactured by: Natco Pharma
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Description

Bortezomib belongs to a group of medicines known as proteasome inhibitors (PIs). It is an antineoplastic agent supplied for intravenous injection (IV) or subcutaneous use (SC). Bortezomib injection is approved for the treatment of adult patients with multiple myeloma (MM) and mantle cell lymphoma (MCL).

Dosage and Side Effects

The recommended initial dose of Bortezomib Injection is 1.3 mg/m2 administered as a 3-5 second bolus intravenous (IV) injection. Dosage administered intravenously (IV) at a concentration of 1 mg/mL or 2.5 mg/mL. Retreatment with Bortezomib may be considered for patients with multiple myeloma (MM) who had earlier responded to therapy with bortezomib injections and who have relapsed at least six months after completing prior bortezomib therapy. Treatment may be initiated at the final tolerated dose. 

The most common side effects of Bortezomib are vomiting, leukopenia, thrombocytopenia, neutropenia, diarrhea, peripheral neuropathy, fatigue, neuralgia, anemia, constipation, lymphopenia, nausea, pyrexia, rash, and anorexia

Warning and Precautions

  • This medicine causes a peripheral neuropathy that is predominantly sensory; however, cases of serious sensory and motor peripheral neuropathy may develop. Individuals experiencing new or worsening peripheral neuropathy during treatment may require a reduction in the dose and/or a less dose-intense schedule.
  • Events of hypotension (orthostatic, postural, and hypotension NOS) may occur during treatment. Those with a previous history of syncope, patients receiving medicines known to be linked with hypotension, and patients who are dehydrated may be at increased risk of hypotension. Adjust antihypertensive drugs, hydration, and administer mineralocorticoids and/or sympathomimetics.
  • Acute Respiratory Distress Syndrome (ARDS) and acute diffuse infiltrative pulmonary disease of unknown etiology such as pneumonitis, interstitial pneumonia, and lung infiltration may occur in all those receiving bortezomib 3.5mg/2mg. Some of these events have been fatal. In the event of any new or worsening cardiopulmonary signs and symptoms, interrupt treatment until a quick and complete diagnostic assessment is conducted.
  • PRES; formerly known as Reversible Posterior Leukoencephalopathy Syndrome (RPLS) may occur in patients receiving treatment with bortezomib. Magnetic Resonance Imaging (MRI), is used for the confirmation of the diagnosis. In those developing PRES, stop bortezomib treatment.
  • Treatment with bortezomib can be responsible for nausea, constipation, diarrhea, and vomiting sometimes requiring the use of antidiarrheal and antiemetic drugs. Ileus can occur. Administer fluid and electrolyte replacement to prevent dehydration. Interrupt this treatment for any critical symptom.
  • Bortezomib 2mg/3.5mg can be responsible for causing neutropenia and thrombocytopenia that follow a cyclical pattern with nadirs occurring after the final dose of each cycle and typically recovering before initiating the subsequent cycle. Monitor CBC frequently throughout treatment. Platelet counts need to be measured before each dose.
  • Tumor lysis syndrome (TLS) may occur with bortezomib treatment. Patients at risk of tumor lysis syndrome (TLS) are those with high tumor burden before treatment. Monitor patients Precisely and consider relevant precautions.
  • Mechanism of action and findings suggest that Bortezomib can cause fetal harm when used by a pregnant woman. Due to the potential for serious side effects in a breastfed child from medicine, advise nursing women to avoid breastfeeding during treatment and for 2 months after therapy. 

FAQ's

What is Bortezomib?

Bortezomib is a proteasome inhibitor, widely used for the treatment of Multiple Myeloma and Mantle Cell Lymphoma.

What kind of medicine is Bortezomib?

Bortezomib is a kind of chemotherapy called targeted therapy. It belongs to a class of medications known as proteasome inhibitors.

Where is Bortezomib given?

You have bortezomib either as an injection under the skin (subcutaneous (SC) injection) or as an injection into the bloodstream (intravenously),

How to store Bortezomib?

Store this medicine in a refrigerator at 2° to 8°C (36° to 46°F) in the original package in order to protect it from light.  

What is the cost of Bortezomib?

The medicine bortezomib cost in India is very reasonable and can vary. In order to procure it legally, you can Call us at (+91) 8130290915, TOLL-FREE: 1800-889-1064, Or Write us at info@indiangenericmedicines.com.

Can Bortezomib be used while I’m pregnant?

Bortezomib injections may be unsafe if used during pregnancy. Talk to your clinician about the finest way to help manage your disease in case you want to become pregnant or during pregnancy. 

Can Bortezomib be used while breastfeeding?

Breastfeeding is not recommended while on Bortezomib. Talk to your healthcare professional in case you are breastfeeding or intend to breastfeed.

Where can I get Bortezomib at the best Price? 

Order Bortezomib at the best price today. We request you to Call/WhatsApp us at (+91) 8130290915 or dial our TOLL-FREE Number: 1800-889-1064 or Write us at info@indiangenericmedicines.com. We’re fully committed to providing you with the best Bortezomib price from India. That is why we’ll match the cost/price of any other existing suppliers/distributors in the market who require a medical prescription.

Is Bortezomib available in India?

Bortezomib is a (doctor-prescribed medication, prescription drug, or health care professional-prescribed medicine) pharmaceutical drug that can be legally dispensed against a medical prescription. Bortezomib can be made available through the network of authorized distributors in India. (Hyderabad, Ahmedabad, Kolkata, Chennai, Mumbai, Bangalore, Delhi, Pune, etc.). 

Can You Send the Bortezomib to a Foreign Destination?

Buy Bortezomib online at the best/lowest price from a leading supplier. Indian Generic Medicines can assist in the delivery of Bortezomib; the doctor-prescribed medicine to the UK, Afghanistan, Australia, Philippines, the USA, Saudi Arabia, Thailand, South Africa, Kazakhstan, Uzbekistan, Zambia, Canada, Sri Lanka, Pakistan, China, Kuwait, Sweden, Hong Kong, Turkey, Singapore, Malaysia, Qatar, Japan, Nepal, UAE, and many other countries.

What is the procedure to buy Bortezomib from Indian Generic Medicines? 

Patients can simply fill out the order form or send mail to info@indiangenericmedicines.com. Patients can also send WhatsApp messages to +91 8130290915 or can dial the TOLL-FREE Number: 18008891064. We will reply ASAP with the details of the Bortezomib 2mg/3.5mg price and procurement procedure.

Note:- The order will be confirmed only after the valid receipt of the prescription from the Physician.

Is it safe to buy Bortezomib (Bortenat) online from India?

Yes, one can buy Bortezomib (Bortenat) online from India-based Indian Generic Medicines (IGM) if this medication is not (yet) registered or is unavailable in their respective country. We can help facilitate the export/supply of Bortezomib injections through legal channels.

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