It is a fixed-dose combination of drugs Trifluridine and Tipiracil. Trifluridine is a nucleoside metabolic inhibitor and Tipiracil is a thymidine phosphorylase inhibitor.
It is recommended in patients with:-
- Metastatic colorectal cancer was previously treated with fluoropyrimidine-, oxaliplatin- and irinotecan-based chemotherapy.
- Metastatic gastric or gastroesophageal junction adenocarcinoma was previously treated with at least two prior lines of chemotherapy.
Dosage and Side Effects
The recommended dosage of Trifluridine Tipiracil tablets is 35 mg/m2 up to a maximum of 80 mg per dose (based on the trifluridine component) administered orally twice daily with food on Day 1 till to Days 5 and Days 8 till to Days 12 of each 28-day cycle until disease progression or unacceptable toxicity. The patient should swallow the tablet whole.
The most common side effects of Trifluridine Tipiracil are neutropenia, anemia, nausea, decreased appetite, thrombocytopenia, vomiting, and diarrhea.
What is Trifluridine Tipracil?
Trifluridine is a thymidine-based nucleoside analog, and Tipiracil is a thymidine phosphorylase inhibitor. It is a prescription-only medicine to treat colorectal and gastric cancer patients.
What is the composition of the medicine Trifluridine tipiracil?
The active ingredients in the medicine are Trifluridine and tipiracil hydrochloride, and the inactive ingredients are lactose monohydrate, pregelatinized starch, stearic acid, hypromellose, polyethylene glycol, titanium dioxide, ferric oxide, and magnesium stearate.
What are the strengths in which Trifluridine Tipiracil is available?
- Trifluridine Tipiracil 20 mg/8.19 mg
- Trifluridine Tipiracil 15 mg/6.14 mg
What kind of drug is Lonsurf?
Lonsurf consists of Trifluridine Tipiracil is an anti-cancer chemotherapy drug.
Where can I find Trifluridine tipiracil 15 mg/6.14 mg or 20 mg/8.19 mg?
One can buy this medicine from any certified wholesale generic medicine supplier after getting a prescription from a qualified doctor.
The buyer should check the existing law in their home country before importing the product.