• Medicine Name- Tipanat
  • API- Trifluridine/Tipiracil
  • Packaging- 20 tablets bottle
  • Strength- 15 mg Trifluridine/6.14 mg Tipiracil, 20 mg Trifluridine/8.19 mg Tipiracil
  • Manufactured by- Natco
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It is a fixed-dose combination of the medications tipracil and trifluridine. Tipiracil is an inhibitor of thymidine phosphorylase, while trifluridine is a nucleoside metabolic inhibitor.

It is advised for patients who have:

  • Chemotherapy based on fluoropyrimidines, oxaliplatin, and irinotecan was formerly used to treat metastatic colorectal cancer.
  • Treatment for metastatic gastric or gastroesophageal junction cancer involved at least two rounds of chemotherapy in the past.

Dosage and Side Effects

When taking Trifluridine Tipiracil tablets orally twice daily with food on Days 1 through Days 5 and Days 8 through Days 12 of each 28-day cycle, the recommended dosage is 35 mg/m2 up to a maximum of 80 mg per dose (based on the trifluridine component). This dosage should be continued until the disease progresses or the toxicity becomes intolerable. The tablet should be swallowed whole by the patient.

Trifluridine Tipiracil side effects that occur most frequently include anaemia, thrombocytopenia, nausea, vomiting, diarrhoea, and neutropenia.

Warning and Precautions

  • Prior to and on Day 15 of every Trifluridine Titracil cycle, as well as more frequently as clinically required, get complete blood counts.
  • Trifluridine tipiracil administration may result in thrombocytopenia, anaemia, neutropenia, febrile neutropenia, myelosuppression, and septic shock.
  • In cases of severe myelosuppression, stop taking Trifluridine tipiracil and start again at a reduced dosage.
  • Because trifluridine tipiracil pills can harm the foetus, medical practitioners urge reproductive females to use an effective method of contraception during and for at least six months after the final dose.


What is Trifluridine Tipiracil?

Trifluridine constitutes a thymidine-derived nucleoside analog, while Tipiracil acts as a thymidine phosphorylase inhibitor. This prescription medicine is utilized for treating colorectal and gastric cancer patients.

What comprises Trifluridine Tipiracil?

The active components in this medication encompass Trifluridine and tipiracil hydrochloride, while the inactive constituents include lactose monohydrate, pregelatinized starch, stearic acid, hypromellose, polyethylene glycol, titanium dioxide, ferric oxide, and magnesium stearate.