What is the generic name of Afinitor?
Generic name of Afinitor is Everolimus.
Who is the manufacturer of Afinitor?
Afinitor is manufactured and marketed by Novartis Ltd.
Is Afinitor approved by USA FDA?
Yes, Afinitor is approved by FDA. The product was approved in 2009.
What are the storage conditions of Afinitor?
AFINITOR tablets should be stored at 20°C to 25°C (68°F to 77°F).
How Afinitor is supplied?
Afinitor is supplied as pack of 10 tablets in one strip of 5mg and 10mg .
How does Afinitor work?
Everolimus is an inhibitor of mammalian target of rapamycin (mTOR), a serine-threonine kinase, downstream of the PI3K/AKT pathway. The mTOR pathway is dysregulated in several human cancers and in tuberous sclerosis complex (TSC). Everolimus binds to an intracellular protein, FKBP-12, resulting in an inhibitory complex formation with mTOR complex 1 (mTORC1) and thus inhibition of mTOR kinase activity. Everolimus reduced the activity of S6 ribosomal protein kinase (S6K1) and eukaryotic initiation factor 4E-binding protein (4E-BP1), downstream effectors of mTOR, involved in protein synthesis. S6K1 is a substrate of mTORC1 and phosphorylates the activation domain 1 of the estrogen receptor which results in ligand-independent activation of the receptor. In addition, everolimus inhibited the expression of hypoxia-inducible factor (e.g., HIF-1) and reduced the expression of vascular endothelial growth factor (VEGF).
What is Afinitor used for?
AFINITOR is a kinase inhibitor indicated for the treatment of:
- Postmenopausal women with advanced hormone receptor-positive, HER2- negative breast cancer in combination with exemestane after failure of treatment with letrozole or anastrozole.
- Adults with progressive neuroendocrine tumors of pancreatic origin (PNET) and adults with progressive, well-differentiated, non-functional neuroendocrine tumors (NET) of gastrointestinal (GI) or lung origin that are unresectable, locally advanced or metastatic. Limitation of Use: AFINITOR is not indicated for the treatment of patients with functional carcinoid tumors.
- Adults with advanced renal cell carcinoma (RCC) after failure of treatment with sunitinib or sorafenib. • Adults with renal angiomyolipoma and tuberous sclerosis complex (TSC), not requiring immediate surgery
How many brands of Afinitor are available in India?
Afinitor is an innovator medicine. There are other generic brands available for Everolimus.
Is there any generic or bio similar available for Afinitor.
Yes, there are generic brands available for Afinitor.
Other information about Afinitor
The European Court of Justice has determined that Roche’s Afinitor may be reimbursed for ARMD- despite Novartis and Bayer’s challenge.