API- Bendamustine HCL

Packaging- Single-dose Vial

Strength- 100mg

Get an Enquiry


Bendamustine is an alkylating medication used for the treatment of patients with CLL (Chronic lymphocytic leukemia), and Indolent B-cell non-Hodgkin’s lymphoma (NHL) that has progressed during or within 6 months of the treatment with rituximab or a rituximab containing regimen.

Dosage and Side Effects

The recommended dose for CLL is bendamustine 100 mg/m2, which should be administered intravenously (IV) over 30-minutes on the Days 1’st and 2’nd of a 28 day cycle, up to the 6-cycles.
The recommended dose for NHL is 120mg/m2, which should be administered intravenously over 60 minutes on Days 1’st and 2’nd of a 21 day cycle, up to the 8 cycles.

  • CLL: Most common adverse reactions include pyrexia, nausea, and vomiting.
  • NHL: Most common adverse reactions include nausea, vomiting, fatigue, diarrhea, anorexia, constipation, headache, weight decreased, rash, dyspnea, cough, stomatitis and pyrexia.

Warning and Precautions

  • The bendit should not be used in patients with a known hypersensitivity to bendamustine or mannitol.
  • Patients on bendamustine injection should be monitored for the fever and other signs of the infection and should be treated promptly.
  • Patients receiving treatment with bendamustine hydrochloride should be monitored clinically and the drug should be discontinued in case of severe reactions.
  • Patients with myelosuppression after bendamustine injection 50 mg treatment should be advised to contact a doctor if they have signs or symptoms of infection.
  • Women with childbearing age should be advised to avoid becoming pregnant while on bendamustine 50 mg injection.


Is Bendamustin FDA approved drug?

FDA approved this drug in 2008 for the treatment of Chronic lymphocytic leukemia and many more.

What are all the ingredients of medicine along with Bendamustine?

Bendamustine hydrochloride is the active ingredient, and the inactive ingredient is mannitol.

From which class of drug does Bendamustine belong?

Bendamustine specifically belongs to the class of drugs named alkylating agents. 

What are commonly reported side effects of bendamustine?

Fever, low blood cell counts, nausea, diarrhea, loss of appetite, cough, and rash