Melphalan Injection is an anti-cancer drug used in the treatment of multiple myeloma and ovarian cancer.

Melphalan

  • Medicine Name- Alkacel
  • API- Melphalan
  • Packaging- Lyophilized Powder for Injection
  • Strength- 50 mg
  • Manufactured by- Celon Labs
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Description

Alkacel 50 Injection is a chemotherapy medication primarily used to treat multiple myeloma, ovarian cancer, childhood neuroblastoma (cancer of the nervous system), malignant melanoma (skin cancer), and soft tissue sarcoma (cancer of the muscle, fat, fibrous tissue, blood vessels, or other supporting tissues of the body). It belongs to the class of drugs known as alkylating agents, which inhibit the growth and proliferation of cancer cells by interfering with DNA replication.

The injection contains melphalan hydrochloride as its active ingredient. It is typically supplied in a vial with a lyophilized powder that must be reconstituted with a specified solvent before administration. The reconstituted solution is administered intravenously. 

Melphalan’s mechanism involves forming cross-links between DNA strands, preventing cancer cells from dividing and growing, ultimately leading to cell death. Its effectiveness in targeting rapidly dividing cells makes it particularly useful in treating certain types of cancer.

The dosage and administration of Alkacel 50 Injection depend on the type of cancer, the patient’s body surface area, and overall health. It is typically administered under the supervision of an oncologist in a clinical setting. Monitoring for side effects, such as nausea, vomiting, diarrhea, mouth sores, bone marrow suppression, and liver toxicity, is crucial.

Dosage and Side Effects

The recommended dosage of Melphalan 50 Injection varies by cancer type:

  • Multiple Myeloma: Typically, 16 mg/m² intravenously over 15-20 minutes, repeated every 2 weeks.
  • Ovarian Cancer: 0.2 mg/kg intravenously daily for 5 days, repeated every 4-5 weeks.
  • Childhood Neuroblastoma: 100 mg/m² intravenously as a single dose.
  • Malignant Melanoma: Dosage varies, commonly 2-4 mg/kg intravenously as a single dose, repeated as necessary.
  • Soft Tissue Sarcoma: 100-150 mg/m² intravenously as a single dose, often in combination with other chemotherapy agents.

Dosages of Melphalan injection should be adjusted based on patient response and tolerance.

The most common side effects of Melphalan 50 mg injection are nausea, vomiting, allergic reactions, diarrhea, mouth sores, bone marrow suppression (leading to reduced blood cell counts), increased infection risk, anemia, bleeding, hair loss, and liver toxicity.

Warning and Precautions

  • Melphalan can cause significant bone marrow suppression, leading to low counts of white blood cells, red blood cells, and platelets. Patients should be closely monitored with regular blood tests to manage the risk of infections, anemia, and bleeding.
  • Patients may experience allergic reactions to Alkacel 50 mg, including anaphylaxis, which can be life-threatening. Symptoms may include rash, itching, swelling, severe dizziness, and trouble breathing. Immediate medical attention is required if such reactions occur.
  • Long-term use of this medicine has been associated with the development of secondary cancers, such as acute leukemia. The benefits of treatment should be weighed against this risk, especially for long-term therapy.
  • This medicine is excreted through the kidneys, and patients with pre-existing kidney conditions may require dosage adjustments. Renal function should be regularly assessed during treatment to avoid toxicity.
  • Alkacel injection can cause liver damage. Liver function tests should be performed regularly to monitor for hepatotoxicity. Symptoms of liver issues include jaundice (yellowing of the skin or eyes), dark urine, and severe fatigue.
  • Melphalan can harm a developing fetus and is contraindicated during pregnancy. Both men and women of childbearing potential should use effective contraception during treatment and for a period after the last dose. Breastfeeding is also not recommended during treatment with this medicine.
  • This therapeutic drug can cause severe gastrointestinal side effects such as nausea, vomiting, diarrhea, and mouth sores. Preventative measures and treatments for these side effects should be discussed with the healthcare provider to maintain patient comfort and hydration.

FAQ's

What is Alkacel 50 mg Injection?

Alkacel 50 mg Injection is a medication containing melphalan, an alkylating agent used in chemotherapy to treat multiple myeloma, ovarian cancer, and other malignancies.

How should Melphalan be administered? 

Melphalan is typically administered intravenously under the supervision of a healthcare professional in a clinical setting.

How can I store Melphalan?

Store Melphalan 50 Injection at controlled room temperature (20-25°C) and protect from light. Keep out of reach of children.

How much does Melphalan cost in India?

The cost of Melphalan 50 mg injection in India is reasonable and can vary. To procure this therapeutic drug legally, you can call us at (+91) 8130290915, TOLL-FREE: 1800-889-1064, Or Write us at info@indiangenericmedicines.com.

Can Melphalan be used while I’m pregnant?

Melphalan injections may be unsafe if used during pregnancy. Talk to your doctor about the best way to help control your disease if you want to become pregnant or during pregnancy. 

Can Melphalan be used while breastfeeding?

Breastfeeding is not recommended while on Melphalan. Talk to your doctor if you are breastfeeding or intend to breastfeed.

Where can I get Melphalan at the best Price? 

Order Melphalan at the best price today. We request you to Call/WhatsApp us at (+91) 8130290915 or dial our TOLL-FREE Number: 1800-889-1064 or Write us at info@indiangenericmedicines.com. We are committed to providing you with the best Melphalan price in India. That is why we’ll match the price of any other suppliers/distributors in the market who require a medical prescription.

Is the Melphalan available in India?

Melphalan is a (prescription drug, doctor-prescribed medication, or health care professional-prescribed medicine) pharmaceutical drug that can be legally dispensed against a medical prescription. Melphalan can be made available through the network of authorized distributors in India. (Mumbai, Ahmedabad, Kolkata, Hyderabad, Bangalore, Chennai, Delhi, Pune, etc.). 

Can You Send the Melphalan to Foreign Destinations?

Buy generic Melphalan online at the best/lowest price from a leading supplier. Indian Generic Medicines (IGM) can assist in the delivery of Melphalan; the doctor-prescribed medication to the UK, Canada, UAE, Australia, Philippines, the USA, Saudi Arabia, Thailand, China, South Africa, Kazakhstan, Uzbekistan, Sri Lanka, Zambia, Pakistan, Kuwait, Sweden, Hong Kong, Turkey, Afghanistan, Malaysia, Singapore, Qatar, Japan, Nepal, and many other countries.

What is the procedure for buying Melphalan from Indian Generic Medicines? 

Patients can simply fill out the order form or send mail to info@indiangenericmedicines.com. Patients can also send WhatsApp messages to +91 8130290915 or can dial the TOLL-FREE Number: 18008891064. We will reply ASAP with the details of the Melphalan price and the procurement procedure.

Note:- The order will be confirmed only after the valid receipt of the prescription from the Physician.

Is it safe to buy Melphalan online from India?

Yes, one can buy Melphalan online from India-based Indian Generic Medicines if it is not (yet) registered or is unavailable in your respective country. We can facilitate the supply of Melphalan injection through legal channels.

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