Melphalan

  • Medicine name- Alkacel
  • API- Melphalan Hydrochloride 
  • Pack Size- 25 tablets strips & 1 single-dose vial
  • Strength- 2mg, 5 mg and 50 mg injection
  • Marketed By: Celon Laboratories Ltd
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Description

Melphalan Hydrochloride is an alkylating drug indicated for:  

  • Use as a high-dose conditioning treatment prior to hematopoietic progenitor (stem) cell transplantation in patients with multiple myeloma.

  • The palliative treatment of patients with multiple myeloma for whom oral therapy is not appropriate. 

Dosage and Side Effects

  • For Conditioning Treatment, the recommended dose of Melphalan Hydrochloride is 100 mg/m2/day administered over 30 minutes by intravenous infusion for 2 consecutive days (Day -3 and Day -2) prior to autologous stem cell transplantation (ASCT, Day 0).

  • For Palliative Treatment, the recommended dose of Melphalan Hydrochloride is 16 mg/m2 administered as a single intravenous infusion over 15-20 minutes at 2-week intervals for 4 doses, then, after adequate recovery from toxicity, at 4-week intervals.

Most common adverse reactions observed in at least 50% of patients treated with Melphalan Hydrochloride are neutrophil count decreased, white blood cell count decreased, lymphocyte count decreased, platelet count decreased, diarrhea, nausea, fatigue, hypokalemia, anemia, and vomiting.

Warning and Precautions

  • Gastrointestinal toxicity: Nausea, vomiting, diarrhea or oral mucositis may occur; provide supportive care using antiemetic and antidiarrheal medications as needed.

  • Embryo-fetal toxicity: Can cause fetal harm. Advice of potential risk to the fetus and to avoid pregnancy .

  • Infertility: Melphalan may cause ovarian function suppression or testicular suppression.

FAQ's

What type of drug is Melphalan?

It is an alkylating agent of the bis chloroethyl amine type and a chemotherapy drug used to treat various cancers.

What are the ingredients of the medicine Melphalan?

The active ingredient in the medicine is Melphalan hydrochloride, and the inactive ingredients are Betadex Sulfobutyl Ether Sodium.

Is Alkacel safe in order to use in children?

It is not specified if Alkacel is safe and effective in children.

Is Melphalan available in the form of tablets?

Yes, Melphalan tablets, manufactured by Celon labs, are available.

From where i can buy Melphalan 50 mg?

  • Melphalan price is low if you go with generic brand, you can buy Melphalan from any authorized whole seller after getting prescription from a qualified doctor. It is always better to check the credential of the whole seller/supplier/exporter before buying the product.

  • The buyer should check the existing law in their home country before importing the product.