Hepcinat Lp

  • Medicine Name- Hepcinat LP
  • API- Ledipasvir and Sofosbuvir
  • Packaging- 28 Tablets
  • Strength- 90 mg and 400 mg
  • Manufactured by- Natco Pharma
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Description

Hepcinat LP, a generic version of Harvoni, is a fixed-dose combination of Ledipasvir 90 mg, a hepatitis C virus NS5A inhibitor, and Sofosbuvir 400 mg, an HCV nucleotide analog NS5B polymerase inhibitor. This FDC medicine is used for the treatment of chronic hepatitis C virus (HCV) in adult and pediatric patients aged 3 years and older:

  • Genotype 1/4/5/6 infection either without cirrhosis or with compensated cirrhosis.
  • Genotype 1 infection with decompensated cirrhosis, along with ribavirin.
  • Genotype 1/4 infection who are the recipients of liver transplants either without cirrhosis or with compensated cirrhosis, along with ribavirin.

Dosage and Side Effects

The recommended dosage in adult patients with genotype 1/4/5/6 HCV is one tablet (ledipasvir 90 mg and sofosbuvir 400 mg) taken by mouth once daily with or without food. The daily dosage of ribavirin is weight-based (1000 mg for those <75 kg and 1200 mg for those ≥75 kg) administered by mouth in two divided doses with food. In those with decompensated cirrhosis, the beginning dose of ribavirin is 600 mg and may be titrated up to 1000 mg for individuals <75 kg and 1200 mg for individuals ≥75 kg in two divided doses with food.

The recommended dosage in pediatric patients aged 3 years and older with genotype 1/4/5/6 HCV using Hepcinat LP tablets is based on weight. Patients weighing  35 kg can take one 90 mg/400 mg tablet once daily, patients weighing 17 kg to less than 35 mg can take one 45 mg/200 mg tablet once daily, patients weighing less than 17 kg can take 33.75 mg/150 mg daily orally with or without food.

The most common side effects of Ledipasvir and Sofosbuvir tablets are headache fatigue, and asthenia.

Warning and Precautions

  • Test patients for the presence of any ongoing or previous HBV infection by measuring hepatitis B surface antigen (also known as HBsAg) and hepatitis B core antibody (also called anti-HBc) prior to starting hepatitis C virus treatment with Hepcinat LP tablets.
  • Symptomatic bradycardia, and serious cardiac arrest that may require pacemaker intervention, may establish when amiodarone is coadministered with Ledipasvir-Sofosbuvir. Coadministration of medicine amiodarone with Ledipasvir and Sofosbuvir is not recommended. 
  • The concomitant use of Hepcinat LP and P-gp inducers (such as St. John’s wort and rifampin) may significantly decrease the plasma concentrations of ledipasvir and sofosbuvir and may lead to a reduced therapeutic effect of Hepcinat LP tablets. Therefore, the use of this medicine with P-gp inducers (such as St. John’s wort or rifampin) is not recommended.
  • Patients taking Ledipasvir and Sofosbuvir who develop signs or symptoms of bradycardia need to seek prompt medical assessment. Symptoms may include shortness of breath, fainting, malaise, chest pains, dizziness or lightheadedness, weakness, tiredness, and memory problems.

FAQ's

What is Hepcinat LP?

Hepcinat LP, a generic of Harvoni, is a once-a-day, fixed-dose oral combination medication that contains the main components of Ledipasvir-Sofosbuvir. This antiviral agent is authorized for patients with chronic hepatitis C virus (HCV).

Who has launched the generic Hepcinat LP?

Natco Pharma Ltd has launched the generic Hepcinat LP for treating patients with hepatitis C virus (HCV).

How do I take Ledipasvir-Sofosbuvir? 

Take one tablet (containing ledipasvir 90 mg and sofosbuvir 400 mg) orally, once a day with or without food.

How much does Ledipasvir-Sofosbuvir cost in India?

Ledipasvir-Sofosbuvir cost in India is very reasonable and can vary. To procure this FDC medicine legally, you can call us at (+91) 8130290915, TOLL-FREE: 1800-889-1064, Or Write us at info@indiangenericmedicines.com.

Where can I get Ledipasvir-Sofosbuvir at the best Price? 

Order Hepcinat LP at the best price today. We request you to Call/WhatsApp us at (+91) 8130290915 or dial our TOLL-FREE Number: 1800-889-1064 or Write us at info@indiangenericmedicines.com. We’re fully committed to providing you with the best Ledipasvir-Sofosbuvir price from India. That is why we’ll match the cost/price of any other existing suppliers/distributors in the market who require a medical prescription.

Is the Ledipasvir-Sofosbuvir available in India?

Hepcinat LP is a (prescription drug, doctor-prescribed medication, or health care professional-prescribed medicine) pharmaceutical drug that can be legally dispensed against a medical prescription. Hepcinat LP can be made available through the network of authorized distributors in India. (Bangalore, Ahmedabad, Mumbai, Kolkata, Chennai, Hyderabad, Delhi, Pune, etc.)

Can You Send the Ledipasvir-Sofosbuvir to Foreign Destinations?

Buy Ledipasvir-Sofosbuvir online at the lowest price from a leading supplier. Indian Generic Medicines (IGM) can assist in the delivery of Ledipasvir-Sofosbuvir; the doctor-prescribed medication to the UK, Hong Kong, Canada, the USA, Australia, Philippines, Saudi Arabia, Thailand, China, Kazakhstan, South Africa, Uzbekistan, Sri Lanka, Zambia, Pakistan, Kuwait, Sweden, UAE, Afghanistan, Malaysia,  Japan, Singapore, Turkey, Qatar, Nepal, and many other countries.

What is the procedure for buying Ledipasvir-Sofosbuvir from Indian Generic Medicines

Patients can just fill out the order form or send mail to info@indiangenericmedicines.com. Patients can also send WhatsApp messages to +91 8130290915 or can dial the TOLL-FREE Number: 18008891064. We will reply ASAP with the details of the Ledipasvir-Sofosbuvir price and the procurement procedure.

Note:- The order will be confirmed only after the valid receipt of the prescription from the Physician.

Is it safe to buy Ledipasvir-Sofosbuvir (Hepcinat LP) online from India?

Yes, one can buy Ledipasvir-Sofosbuvir (Hepcinat LP) online from India-based Indian Generic Medicines if it is not (yet) registered or is unavailable in their respective country. We can facilitate the supply/export of Hepcinat LP through legal channels.