• Medicine Name- Hyponat O 
  • API- Tolvaptan 
  • Pack Size – 10 Tablets strip
  • Strength- 15mg/30mg 
  • Manufactured by- Zydus Cadila
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A selective vasopressin V2-receptor antagonist called tolvaptan tablet is used to treat patients with heart failure, cirrhosis, and Syndrome of Inappropriate Antidiuretic Hormone (SIADH) who have clinically significant hypervolemic and euvolemic hyponatremia, defined as serum sodium <125 mEq/L or less marked hyponatremia that is symptomatic and has resisted correction with fluid restriction. 

Dosage and Side Effects

Tolvaptan tablets are often started at a dose of 15 mg once daily, without regard to meals. If necessary to reach the target level of serum sodium, the dose can be raised to 30 mg once daily, up to a maximum of 60 mg once daily, after at least 24 hours. Always keep an eye out for variations in the volume and serum electrolytes during the beginning and titration phases. Don’t forget to take your Tolvaptan tablet’s dosages. Take the missed dose as soon as you remember it if you miss it. If the next dose is almost here, skip the one you missed. Simply take the subsequent dosage around your scheduled time. Never take more than one dose at once.

Warning and Precautions

  • Upon cessation of tolvaptan tablets 15 mg, patients should revert to their fluid restriction regimen and undergo monitoring for alterations in serum sodium levels and volume status. 
  • Continuous monitoring of serum sodium concentrations and neurological condition is imperative for patients undergoing tolvaptan treatment, particularly during commencement and dose adjustment. 
  • In the event of a swift surge in serum sodium levels, discontinue or suspend tolvaptan usage and contemplate the administration of hypotonic fluids. 
  • Exercising fluid restriction in the initial 24 hours of tolvaptan therapy may heighten the risk of excessively rapid correction of serum sodium and is generally discouraged.
  • Restricting fluid intake while on tolvaptan therapy, such as with Samsca, could elevate the likelihood of dehydration and diminished blood volume. Patients should heed their thirst cues and continue fluid intake accordingly.
  • Individuals undergoing tolvaptan therapy should refrain from attempting to conceive or breastfeed an infant during treatment. 
  • Consumption of grapefruit juice while taking tab tolvaptan 15 mg should be avoided as it may elevate tolvaptan levels in the bloodstream beyond acceptable limits.


How does Tolvaptan Tablet work? 

To boost low blood sodium levels in adults with illnesses such liver disease, heart failure, and specific hormone imbalances, Tolvaptan tablets is a prescription medication. Tolvaptan tablet helps the body rid itself of excess water in the urine, which raises blood salt levels. 

Which Tolvaptan tablet dose strengths are available? 

There are two dosing strengths for the tablet, which are as follows: 

  • tolvaptan 15 mg 
  • tolvaptan 30 mg