Thiotepa (Thioplan)

  • Medicine Name- Thioplan
  • API- Thiotepa
  • Packaging- Single-use vial
  • Strength- 15 mg/Vial
  • Manufactured by- Natco Pharma
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Description

Thiotepa, an alkylating agent, is supplied generically under the brand Thioplan. This therapeutic drug is used:

  • To mitigate the risk of graft rejection when used in conjunction with high-dose busulfan and cyclophosphamide as a preparative regimen for allogeneic hematopoietic progenitor (stem) cell transplantation (HSCT) in pediatric patients with class 3 beta-thalassemia.
  • For the management of adenocarcinoma affecting the breast or ovary.
  • For managing intracavitary effusions arising from diffuse or localized neoplastic conditions affecting different serosal cavities.
  • For treatment of superficial papillary carcinoma of the urinary bladder.

Dosage & Side-effects

For class 3 beta-thalassemia, the recommended dose of Thiotepa is two intravenous administrations of 5 mg/kg each, approximately 12 hours apart on Day -6 before allogeneic HSCT, combined with high-dose busulfan and cyclophosphamide.

For adenocarcinoma of the breast or ovary, the recommended intravenous dose of Thiotepa ranges from 0.3 to 0.4 mg/kg.

For the treatment of malignant effusions, the recommended intracavitary dose of Thiotepa ranges from 0.6 mg/kg to 0.8 mg/kg.

For treating superficial papillary carcinoma of the urinary bladder, the recommended dose of Thiotepa is 60 mg administered into the bladder via a catheter in 30 to 60 mL of Sodium Chloride Injection.

The most common side effects of Thiotepa injection are hemorrhage, elevated alanine aminotransferase, anemia, diarrhea, neutropenia, thrombocytopenia, elevated aspartate aminotransferase, rash, elevated bilirubin, cytomegalovirus infection, mucositis, and hematuria.

Warnings & precautions

  • Administering high doses of Thiotepa alongside other chemotherapy as prescribed for class 3 beta-thalassemia can lead to significant myelosuppression in all patients. It’s crucial to refrain from initiating the preparative regimen without a stem cell donor. Regularly monitor complete blood counts (CBC) and offer supportive care for infections, anemia, and thrombocytopenia until adequate hematopoietic recovery occurs.
  • For patients undergoing Thioplan 15 mg treatment for breast adenocarcinoma, ovarian adenocarcinoma, malignant effusions, or urinary bladder papillary carcinoma, caution is advised if the bone marrow is compromised or recovering from prior treatment. Regular CBC monitoring is recommended, with supportive care for related symptoms.
  • In the event of clinically significant hypersensitivity reactions, including anaphylaxis, associated with Thiotepa usage, discontinue treatment, administer appropriate therapy, and closely monitor patients until resolution of signs and symptoms.
  • In the event of accidental exposure to Thiotepa 15 mg treatment, skin reactions may occur. Rinse the affected skin thoroughly with soap and water. If the solution comes into contact with mucous membranes, flush them immediately.

FAQs

What is Thiotepa?

Thiotepa is a chemotherapy medication used to treat various types of cancer, including bladder cancer, breast cancer, and ovarian cancer. 

How is Thiotepa administered

The recommended dosage of Thiotepa is administered intravenously, intracavitary, or intravesically.

How can I store Thiotepa?

Thiotepa should be stored at controlled room temperature, between 20°C to 25°C (68°F to 77°F), in a dry place away from direct sunlight and moisture.

How much does Thiotepa cost in India?

Thiotepa 15 mg cost in India is reasonable and can vary. To procure it legally, you can call us at (+91) 8130290915, TOLL-FREE: 1800-889-1064, Or Write us at info@indiangenericmedicines.com.

Can Thiotepa be used while I’m pregnant?

Thiotepa may be unsafe if used during pregnancy. Talk to your healthcare provider (HCP) about the best way to help control your disease if you want to become pregnant or during pregnancy. 

Can Thiotepa be used while breastfeeding?

Breastfeeding is not recommended while on Thiotepa. Talk to your healthcare provider (HCP) if you are breastfeeding or intend to breastfeed.

Where can I get Thiotepa at the best Price? 

Order Thiotepa at the best price today. We request you to Call/WhatsApp us at (+91) 8130290915 or dial our TOLL-FREE Number: 1800-889-1064 or Write us at info@indiangenericmedicines.com. We are fully committed to providing you with the best Thiotepa 15 mg price from India. That is why we will match the price of any other facilitators/suppliers/distributors in the market who require a medical prescription.

Is the Thiotepa available in India?

Thiotepa is a (prescription drug, doctor-prescribed medication, or health care professional-prescribed medicine) pharmaceutical drug that can be legally dispensed against a medical prescription. Thiotepa can be made available through the network of authorized distributors in India. (Mumbai, Ahmedabad, Kolkata, Hyderabad, Delhi, Bangalore, Chennai, Pune, etc.)

Can You Send the Thiotepa to Foreign Destinations?

Buy generic Thiotepa online at the best/lowest price from a leading supplier. Indian Generic Medicines (IGM) can assist in the delivery of Thiotepa; the doctor-prescribed medication to the UK, Canada, South Africa, Australia, China, Kazakhstan, Philippines, the USA, Saudi Arabia, Thailand, Uzbekistan, Zambia, Pakistan, UAE, Turkey, Kuwait, Sri Lanka, Sweden, Hong Kong, Afghanistan, Malaysia, Singapore, Qatar, Nepal, Japan, and many other countries.

What is the procedure to buy Thiotepa from Indian Generic Medicines

Patients can fill out the order form or send mail to info@indiangenericmedicines.com. Patients can also send WhatsApp messages to +91 8130290915 or can dial the TOLL-FREE Number: 18008891064. We will reply ASAP with the details of the Thiotepa 15 mg price and the procurement procedure.

Note:- The order will be confirmed only after the valid receipt of the prescription from the Physician.

Is it safe to buy Thiotepa online from India?

Yes, one can buy Thiotepa 15 mg online from India-based Indian Generic Medicines if the medicine is not (yet) registered or is unavailable in their respective country. We can help facilitate the supply of Thiotepa through legal channels.