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VORICONAZOLE is an antifungal medication indicated for the treatment of: Fungal Infections: includes aspergillosis, candidiasis, coccidioidomycosis, histoplasmosis, penicilliosis, and infections by Scedosporium or Fusarium. This medication also can be used in order to prevent fungal infection in people as they undergo Bone Marrow Transplant. This is also the recommended medication for the CNS fungal infections which is transmitted by epidural injection of contaminated steroids.

Dosage and Side Effects

Voriconazole or Vorier is intended for administration by intravenous infusion. It is a single-dose, unpreserved product. Your doctor or nurse may give you this medication through a needle in your vein (intravenous, I.V.). It takes 1 to 2 hours to get each dose.

  • Most common side effects of Voriconazole Injection include peripheral edema, headaches, trouble breathing, diarrhea, vomiting, abdominal pain, nausea, rashes, fever,  anxiety, insomnia, confusion, weakness, tingling, sleepiness, dizziness, irregular heartbeats, slow or fast heartbeats, low blood pressure, stomach upset, constipation, jaundice, hair loss, flaky skin, itchiness, red skin, back pain, chest pain, and chills.
  • Some adverse effects may also appear in patients with this drug which are as squamous cell skin cancer, damage due to phototoxicity, and Stevens-Johnson syndrome; in long-term use, there is a warning of the risk of bone fluorosis and periostitis.

Warning and Precautions

  • It is toxic to the fetus; pregnant women should not take it and women taking it should not become pregnant. Use during pregnancy may result in harm to the baby.
  • People who have hereditary intolerance for galactose, Lapp lactase deficiency, or glucose-galactose malabsorption should not take this drug.
  • It should be used with caution in people with arrhythmias or long QT.
  • In long-term use, there is a warning of the risk of bone fluorosis and periostitis.
  • Vorier should not be used in conjunction with many drugs including sirolimus, rifampicin, rifabutin, carbamazepine, quinidine, and ergot alkaloids).
  • Intravenous use of Voriconazole 200mg must be avoided in patients with severe as well as moderate renal impairment, unless an assessment of the risk/benefit to the patient clarifies the use of intravenous voriconazole.
  • People with this medication should avoid night driving, because VFEND may cause vision problems like blurry vision.
  • Also need to avoid all driving or using dangerous machinery, if you have any change in your eyesight.
  • No dose adjustment is needed for renal impairment or advanced age, but children seem to clear voriconazole faster than adults and drug levels may need monitoring.


How does Voriconazole works?

Voriconazole works by affecting the fungal metabolism and fungal cell membranes.

What is the active Ingredients of Vorier Injection

Active ingredient of Vorier is Voriconazole.

What are the inactive ingredients of the medicine Voriconazole?

The inactive ingredient is sulfobutyl ether beta-cyclodextrin sodium.

What are the uses of Voriconazole?

Voriconazole 200 mg is prescribed for the treatment of numerous fungal infections:

  • aspergillosis
  • candidiasis
  • coccidioidomycosis
  • histoplasmosis
  • penicilliosis
  • and infections by Scedosporium or Fusarium.

When Voriconazole was patented and approved?

In 1990 Voriconazole was patented and in 2002 this medication was approved for medical use in the United States.