One macrolide drug, Sirolimus Tablets was approved for treatment of:
With or without food, sirolimus should be taken orally at roughly the same time every day. It is recommended to take sirolimux tablets whole, along with water. The tablet must not be chewed, opened, or damaged.
A decrease in glucose tolerance and insulin sensitivity, dizziness, leg swelling, thrombocytopenia, pain, headache, abdominal pain, acne, chest pain, hypertension, hypertriglyceridemia, fever, hypercholesterolemia, creatinine, anemia, nausea, urinary tract infection, arthralgia, sore throat, and dizziness are the most frequent side effects of sirolimus.
Sirolimus 1 mg should not be used by those with a known hypersensitivity to the drug. The safety of LAM treatment using sirolimus has not been assessed in individuals under 18 years old.Â
Using sirolimus may elevate the risk of developing type 2 diabetes. Lung toxicity, particularly in lung transplant cases, can be a severe complication of sirolimus therapy.
There are warnings associated with sirolimus use in transplants as it might heighten mortality risk due to an increased susceptibility to infections. Sirolimus tablets could potentially heighten the risk of skin cancers with exposure to sunlight or UV radiation, as well as the risk of developing lymphoma.
Individuals taking sirolimus 1 mg face an increased likelihood of experiencing impaired or delayed wound healing, especially if their body mass index exceeds 30 kg/m2. Sirolimus dosage, also known as rapamycin dosage, is metabolized by the CYP3A4 enzyme and acts as a substrate for the P-glycoprotein (P-gp) efflux pump.Â
Consequently, inhibitors of either protein may escalate sirolimus concentrations in the bloodstream, while P-gp and CYP3A4 inducers may lower these concentrations.
Women capable of bearing children should be advised to avoid pregnancy while on or during Rapamune therapy.Â
Since sirolimus is not absorbed through the skin, no special precautions are necessary. However, if direct contact occurs with the skin or mucous membranes, immediate washing with soap and water is recommended, along with rinsing the eyes with plain water.
What are the uses of Sirolimus?
Sirolimus is prescribed to prevent organ transplant rejection and to treat LAM (lymphangioleiomyomatosis).
Is Sirolimus safe to use on its own?
Sirolimus can be used alone or combined with a calcineurin inhibitor (such as tacrolimus) and/or mycophenolate mofetil to create steroid-free immunosuppression regimens.
What components make up Sirolimus medication?
The active ingredient in Sirolimus is Sirolimus itself, while the inactive ingredients include sucrose, lactose, polyethylene glycol 8000, calcium sulfate, microcrystalline cellulose, pharmaceutical glaze, talc, titanium dioxide, magnesium stearate, povidone, poloxamer 188, polyethylene glycol 20,000, glyceryl monooleate, carnauba wax, and dl-alpha-tocopherol.
Was Sirolimus or Rapamycin initially designed as an antifungal agent?
Yes, Sirolimus/Rapamycin was originally developed as an antifungal medication.
What type of compound is Sirolimus?
Sirolimus belongs to the class of macrolide compounds.
The Indian Generic Medicines is a Consultancy and Service company providing access to genuine generic medicines to patients all across the world. We also have own pharmacy named as Indian Generic Medicines which work under compliant distribution guidelines.
© 2024 Indian Generic Medicines. All rights reserved.
