Darunavir-ritonavir

Darunavir Ritonavir

API- Darunavir Ritonavir

Packaging- 60 Tablets

Strength- 400mg/50mg

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Description

Darunavir: 

  • This is a protease inhibitor (PI) that inhibits the replication of the HIV virus in combination with other antiretroviral agents (ARV). 
  • Initial studies indicate that darunavir may be active against strains of HIV that are already resistant to some other currently available protease inhibitors.

Ritonavir:

  • This is also a protease inhibitor used to inhibit the replication of the HIV virus in combination with other antiretroviral agents or to increase blood levels of other protease inhibitors. 

The combination of darunavir and ritonavir are taken together because ritonavir will “boost” the level of darunavir and increase its effect.

Dosage and Side Effects

Darunavir and ritonavir should be taken orally at about the same time each day, Durart R tablets should be taken with food to increase absorption and decrease side effects.

Darunavir and ritonavir tablets should be swallowed whole with water. The tablets should not be opened, broken, or chewed.

  • Darunavir: Most common side effects of darunavir include nausea, vomiting, diarrhea, stomach pain or gas , tiredness, allergic skin rash, headache, yellowing of the skin or eyes, and pale stool.
  • Ritonavir: The most common side effects include nausea, diarrhea, vomiting, stomach pain, taste changes, and abnormal feelings in the hands, feet, or in and around the mouth.

Warning and Precautions

  • Some medications can interact with darunavir and/or ritonavir requiring a dosage adjustment or an alternate medication: eg. Some antihistamines, sedatives, anti-tuberculosis medications, some antifungal medications, narcotic analgesics, methadone, heart/blood-pressure medications, psychiatric medications, anticonvulsants, transplant/immunosuppressant medications, warfarin, cholesterol-lowering agents, sildenafil (Viagra), oral contraceptives (birth control pill), ergot containing migraine medications.
  • Avoid the following Herbal/Natural remedies: St. John’s Wort, Milk Thistle, raw Garlic or Garlic capsules which may decrease levels of darunavir.
  • Protease inhibitors not only interact with each other, but may change the level of
  • other medications (by changing the processing of drugs in your liver).
  • Always check with the pharmacist or your doctor before starting any new medications (prescription, non-prescription and herbal) to ensure the safety of the combination.
  • The consumption of alcohol is not recommended while on the initial 4 weeks of the therapy and also alcohol should be used with caution thereafter.
  • In order to the increased absorption and decreases in the side effects, Darunavir and ritonavir should be taken with food.
  • The combined darunavir and ritonavir should be consumed at the same time every day, because missing doses or taking doses late can lead to the development of drug resistance.
  • Darunavir has been shown to increase total cholesterol and/or triglyceride levels. Redistribution or accumulation/loss of body fat (lipodystrophy) and also increases in the blood sugars can occur.
  • Sometimes Darunavir may affect your liver and cause a change in liver function tests. Contact your healthcare provider if you have stomach pain that doesn’t go away and/or have signs of jaundice (e.g. yellowing of the skin or eyes, pale stool etc).

FAQ's

What is HIV infection?

HIV (human immunodeficiency viruses) over time causes acquired immunodeficiency syndrome (AIDS). It is a condition in which the immune system weakens, leading the body to become prone to infections and cancers.

What does Darunavir Ritonavir do?

Darunavir and Ritonavir are used in combination for treating patients suffering from HIV infection. It inhibits the replication of HIV.

Is Durarat R 450 a fixed-dose combination medication?

Yes, it is a Fixed-Dose Combination (FDC) drug comprising Darunavir 400mg & Ritonavir 50mg for treatment experienced adults and adolescents weighing more than 40kg with HIV-1.

What is the motive behind using fixed-dose combination therapy of Darunavir Ritonavir?

The fixed-dose combination therapy may improve the overall patient treatment outcome.

In what forms Darunavir Ritonavir comes?

Darunavir is available in 600 mg and 800 mg dose forms & Ritonavir is available in the 100 mg and 50 mg dose forms.

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