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Trabectedin is an alkylating medication used to treat patients with unresectable or metastatic liposarcoma or leiomyosarcoma who have taken an earlier anthracycline-containing regimen.

Dosage and Side Effects

The standard dose of Trabectedin is 1.5 mg/m2 which should be administered as an intravenous infusion over 24 hours through a central venous line every 3 weeks or 21 days, until the disease is progressive or unacceptable toxicity occurred, in patients with normal bilirubin and AST or ALT less than or equal to 2.5 times the upper limit of normal.

Commonly reported trabectedin side effects include: constipation, nausea, fatigue, decreased appetite, peripheral edema, vomiting, diarrhea, dyspnea, headache.

Warning and Precautions

  • Administer the dexamethasone 20 mg intravenously 30 minutes before each dose of Trabectedin.
  • Trabectedin 1 mg is contraindicated in patients with severe hypersensitivity, including anaphylaxis, to trabectedin.
  • Neutrophil count needs to be assessed before the administration of each dose of Trabectedin and then periodically throughout the therapy.
  • Assess LFTs before each administration of trabectedin injection. Manage the elevated LFTs with interruption of therapy, dose reduction, or permanent discontinuation based on severity and duration of LFT abnormality.
  • Assess left ventricular ejection fraction (LVEF) by echocardiogram or MUGA (Multigated Acquisition) scan prior to beginning of trabectedin and at 2-3 month intervals thereafter until the therapy is discontinued.
  • Based on its mechanism of action, trabectedin injection can cause fetal harm in cases administered to a pregnant woman.
  • Due to potential for severe adverse events from trabectedin in breastfed infants, nursing women are advised to interrupt nursing while on trabectedin treatment.


What is Trabectedin?

Trabectedin specifically is an antitumor chemo medicine aimed to treat advanced soft-tissue sarcoma and ovarian cancer.

How should Trabectedin 0.25 mg be administered? 

Trabectedin 0.25 mg should be administered as an intravenous infusion. 

Who should not receive Trabectedin? 

You will not be given trabectedin if you have had a severe allergic reaction to Trabectedin. 

What should I avoid while receiving Trabectedin?

Patients are advised to avoid grapefruit as well as grapefruit juice while on therapy with Trabectedin.

Where can I buy Trabectedin? 

You can buy Trabectedin from any authorized whole-seller after getting a prescription from a qualified doctor. It is always better to check the credential of the whole-seller/supplier/exporter before buying the product.

The buyer should check the existing law in their home country before importing the product.