Trabectedin Injection

Trabectedin

  • Medicine Name- Trabec natco
  • API- Trabectedin
  • Packaging- 1 Single-dose vial
  • Strength- 1mg
  • Manufactured by- Natco

Note: Trabectedin is a prescription medicine and should only be used under a qualified doctor’s guidance. Do not use it without a prescription or recommend/give it to anyone else without medical advice. Follow your doctor’s instructions and consult a healthcare professional regarding its use, safety, or side effects.

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Description

Trabectedin Injection

Trabectedin Injection is a prescription anticancer medicine used in the treatment of certain advanced soft-tissue sarcomas. It is indicated for adults with unresectable or metastatic leiomyosarcoma or liposarcoma who have previously received an anthracycline-containing chemotherapy regimen.

Trabectedin is administered by intravenous infusion under the supervision of a qualified healthcare professional. The appropriate dose and treatment schedule depend on the patient’s medical condition, previous treatment, liver function and response to therapy.

Trabectedin Injection Uses

Trabectedin Injection 1mg is used for eligible adult patients with:

  • Leiomyosarcoma – unresectable or metastatic disease following previous anthracycline-containing therapy.
  • Liposarcoma – unresectable or metastatic disease following previous anthracycline-containing therapy.

The exact indication, dosage and treatment protocol should be confirmed from the approved product information applicable to the specific product and country.

Trabectedin Injection 1mg Price & Availability

Trabectedin Injection availability and pricing may vary according to the strength, presentation, manufacturer, quantity and destination country. Product availability can be checked for individual requirements, including institutional and pharmaceutical procurement.

Trabectedin Supplier from India

Indian Generic Medicines supports Trabectedin pharmaceutical supply from India for eligible procurement requirements. Hospitals, distributors, wholesalers, NGOs, importers and international pharmaceutical buyers can enquire about the required product presentation, quantity, availability and applicable documentation.

Trabectedin Export from India

For international requirements, Trabectedin can be assessed for pharmaceutical export from India based on product availability, destination-country requirements and applicable regulatory and logistics conditions. Buyers should provide the required strength, quantity and destination country when submitting an enquiry.

Trabectedin Product Documentation

Depending on the product and manufacturer, buyers may request available documentation such as:

  • Product Specifications,
  • Batch Details,
  • Certificate of Analysis (CoA),
  • Manufacturing information and other applicable regulatory documents.

Please consult a qualified healthcare professional for guidance, as the approved use and treatment of Trabectedin may vary depending on the product and country.

Dosage and Side Effects

In patients with normal bilirubin levels and AST or ALT levels less than or equal to 2.5 times the upper limit of normal, the standard dose of Trabectedin is 1.5 mg/m2. This medication should be given as an intravenous infusion over 24 hours through a central venous line every three weeks or 21 days, until the disease progresses or unacceptable toxicity occurs.

Constipation, nausea, exhaustion, decreased appetite, peripheral edoema, vomiting, diarrhoea, dyspnea, and headache are among the side effects of trabectedin that are frequently observed.

Warning and Precautions

  • Give the intravenous dexamethasone dosage of 20 mg half an hour before to each Trabectedin dose.
  • Patients who have severe allergy to trabectedin, including anaphylaxis, should not take 1 mg of trabectedin.
  • Before each Trabectedin dose is administered and subsequently on a recurring basis during the course of treatment, the neutrophil count must be evaluated.
  • Examine LFTs prior to each injection of trabectedin. Depending on the degree and length of the LFT anomaly, manage the increased LFTs by stopping therapy, reducing the dose, or permanently stopping the medication.
  • Evaluate the left ventricular ejection fraction (LVEF) with an echocardiography or MUGA (Multigated Acquisition) scan before starting trabectedin and then every two to three months until the medication is stopped.
  • When given to a pregnant woman, trabectedin injection has the potential to harm the foetus due to its mode of action.
  • Nursing women are recommended to stop nursing while on trabectedin medication due to the possibility of serious side effects in breastfed infants.

FAQ's

What is Trabectedin?

In particular, Trabectedin is an anticancer chemotherapy drug used to treat ovarian cancer and advanced soft-tissue sarcoma.

How should 0.25 mg of Trabectedin be administered? 

The recommended method of administration for Trabectedin 0.25 mg is intravenous infusion. 

Who should not receive Trabectedin? 

If you have experienced a severe allergic reaction to trabectedin, you will not be administered trabectedin.

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