Nitisinone

  • Medicine Name- Lasinone 
  • API- Nitisinone
  • Packaging- 60 Capsules
  • Strength- 2 mg,5 mg and 10 mg
  • Manufactured by: Laurus Labs
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Description

Nitisinone 2 mg, 5 mg and 10 mg capsule is generically available under the brand Lasinone. It is also available as a trade name drug under the brand Orfadin among others. Nitisinone Capsule is used for the treatment of adult and pediatric patients (in any age range) with a confirmed diagnosis of HT-1 (Hereditary tyrosinemia type-1 or Tyrosinemia type-1) in conjunction with dietary restriction of phenylalanine and tyrosine.

HT-1 is a condition in which the body can’t break down a substance called tyrosine properly, which can build up and cause serious health problems. Nitisinone Capsule helps to block an enzyme in the body that’s involved in making harmful substances from tyrosine. By blocking this enzyme, nitisinone helps to reduce the levels of these harmful substances in the body, which can prevent damage to the liver, kidneys, and other organs.

Nitisinone Capsule is currently approved in dosage strengths of 2 mg, 5 mg, and 10 mg. The dosage of Nitisinone is usually taken as a capsule by mouth, once a day. It’s crucial to take the dosage at the same time each day as per doctor’s advice. While taking Nitisinone Capsule, a doctor will monitor the blood regularly to make sure the therapeutic drug is working well and to check for any potential side effects.

Dosage and Side Effects

Nitisinone capsule should be taken orally twice a day, at least 60 minutes before or 120 minutes after a meal, with a beginning dosage of 0.5 mg per kilogram. If, following at least four weeks on an astable dosage of Nitisinone capsule, patients aged five years and older had undetectable blood and urine succinylacetone concentrations, the entire daily dosage could be administered once daily (e.g., 1 mg/kg to 2 mg/kg once daily). 

The dietary limitation of phenylalanine and tyrosine must be upheld. Nitisinone capsule dosages can be adjusted for each patient based on their unique reaction to treatment, both biochemically and clinically.

Conjunctivitis, eye pain, dry skin, elevated tyrosine levels, thrombocytopenia, leukopenia, corneal opacity, photophobia, blepharitis, cataracts, keratitis, granulocytopenia, epistaxis, exfoliative dermatitis, maculopapular rash, pruritus, and alopecia are among the most frequently reported side effects of Nitisinone capsules.

Warning and Precautions

  • Nitisinone Capsules can raise tyrosine levels in the body by blocking an enzyme involved in its breakdown,
  • Using Nitisinone Capsule may cause eye problems like redness, sensitivity to light, and vision issues. Before starting and during treatment, regular eye check-ups are vital.
  • While on Nitisinone Capsule therapy and a restricted diet, there might be temporary drops in white blood cells and platelets. Regular checks for these levels are necessary.
    • Those taking Nitisinone capsules need regular checks for certain substances in the body and liver function. Watching the intake of specific foods is also important.
  • If pregnant, using Nitisinone capsule is carefully considered based on potential risks. Nursing women should talk to their doctor about stopping Nitisinone generic treatment or breastfeeding.

FAQ's

What is Lasinone?

Lasinone Capsule is a generic brand that contains Nitisinone, as an active substance. It is used to treat hereditary tyrosinemia type 1 (HT-1), a rare genetic disorder that affects the body’s ability to break down the amino acid tyrosine. 

How is Nitisinone supplied?

Nitisinone capsule is typically supplied in the form of capsules for oral administration. These capsules are available in various strengths, such as 2 mg, 5 mg, and 10 mg, depending on the manufacturer and specific product. 

How can I take Nitisinone capsules?

Nitisinone capsules are typically taken orally with water, as directed by your Clinician. Preferably it should be taken at the same time each day with or without food, but consistency in timing is crucial for positive outcomes. 

How much does Nitisinone cost in India?

The Nitisinone Capsule Price in India is reasonable and can vary. Call/WhatsApp: +91 8130290915 or dial TOLL-FREE: 1800-889-1064 to get the latest Nitisinone Capsule cost. If you want to procure Nitisinone capsules online, then Indian Generic Medicines (IGM) can help you access this medicinal product at the most competitive price through legal channels.

Where can I get Nitisinone Capsules at the best price?

Order Nitisinone at the best price today. We request you to Call/WhatsApp us at (+91) 8130290915 or dial our TOLL-FREE Number: 1800-889-1064 or Write us at info@indiangenericmedicines.com. We are fully committed to providing you with the best Nitisinone Capsule price from India. That is why we’ll match the cost/price of any other existing facilitators/suppliers/distributors in the market who require a medical prescription.

Is Nitisinone available in India?

Nitisinone capsule is a (prescription drug, doctor-prescribed medication, or health care professional-prescribed medicine) pharmaceutical drug that can be legally dispensed against a medical prescription. Nitisinone capsule can be made available through the network of authorized distributors in India. (Mumbai, Ahmedabad, Bangalore, Chennai, Kolkata, Hyderabad, Delhi, Pune, etc.). 

Can You Send Nitisinone to Foreign Destinations?

Buy generic Nitisinone capsule online at the best/lowest price from a leading supplier. Indian Generic Medicines (IGM) can assist in the delivery of Nitisinone Capsule; the doctor-prescribed medicine to the UK, Canada, Saudi Arabia, Philippines, Australia, the USA, China, Thailand, South Africa, Oman,  Uzbekistan, Kazakhstan, Zambia, Hong Kong, UAE, Pakistan, Kuwait, Sri Lanka, Sweden, Malaysia, Singapore, Turkey, Afghanistan, Qatar, Japan, Nepal, and many other countries.

What is the procedure to buy Nitisinone from Indian Generic Medicines? 

Patients can fill out the order form or send mail to info@indiangenericmedicines.com. Patients can also send WhatsApp messages to +91 8130290915 or can dial the TOLL-FREE Number: 18008891064. We will reply ASAP with the details of the Nitisinone Capsule price and the procurement procedure.

Note:- The order will be confirmed only after the valid receipt of the prescription from the Physician.

Is it safe to buy Nitisinone online from India?

Yes, one can buy Nitisinone capsule online at the best price from The Indian Generic Medicines (IGM) if the drug is not registered or is unavailable in their country. We can help facilitate the supply of Nitisinone through legal channels.

What are the common side effects associated with Nitisinone Capsules?

Side effects can include eye-related issues like conjunctivitis and vision problems, as well as elevated tyrosine levels, skin conditions, and blood-related concerns such as drops in white blood cells and platelets.

What precautions are important to consider while taking Nitisinone Capsules?

Regular eye check-ups are crucial during treatment. Additionally, maintaining a restricted diet and monitoring blood cell counts are essential. There’s also a consideration for using Nitisinone capsule instead of oral suspension due to potential gastrointestinal side effects.

Are there specific considerations for pregnant or nursing individuals using Nitisinone?

Using Nitisinone capsule during pregnancy should be carefully weighed against potential risks, and nursing women should consult their doctor regarding treatment continuation or breastfeeding.