Linezolid Oral/Injection & tablets

Linezolid

  • Medicine Name- Linospan
  • API- Linezolid
  • Packaging- Injectable solution, Oral suspension, and Tablets
  • Strength- 2 mg/mL, 100 mg/5 mL, and 600 mg
  • Manufactured by- Cipla Ltd
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Description

Linezolid is an antibiotic used to treat various bacterial infections, particularly those caused by Gram-positive bacteria. It belongs to the oxazolidinone class of antimicrobials, which function by inhibiting bacterial protein synthesis, thereby stopping bacterial growth. Linezolid is effective against a wide range of bacteria, including resistant strains such as methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE). The primary indications are as follows:

  • Nosocomial Pneumonia: The medicine is indicated for the treatment of hospital-acquired pneumonia, particularly when caused by MRSA or other Gram-positive pathogens. It is used in cases where standard antibiotics are ineffective or contraindicated.
  • Community-Acquired Pneumonia (CAP): This therapeutic drug can also treat community-acquired pneumonia caused by susceptible strains of Streptococcus pneumoniae and Staphylococcus aureus, including MRSA.
  • Skin and Soft Tissue Infections: It is prescribed for complicated skin and soft tissue infections (cSSTIs), including diabetic foot infections without osteomyelitis, caused by susceptible Gram-positive bacteria.
  • Vancomycin-Resistant Enterococcal Infections: It is used to treat infections caused by vancomycin-resistant Enterococcus faecium (VRE), including cases with concurrent bacteremia.
  • Multi-Resistant Gram-Positive Infections: This medicinal product is a valuable option for treating other serious infections caused by multi-drug resistant Gram-positive bacteria when alternative treatments are not effective or available.

Dosage and Side Effects

Linezolid is available in oral and intravenous formulations, allowing flexibility in treatment. The dosages of intravenous and tablet formulations are interchangeable. For pediatric patients, the dosage is adjusted based on body weight and clinical condition. The recommended adult dosing is as follows:

  • Nosocomial pneumonia: The recommended dose for nosocomial pneumonia is 600 mg, administered IV or orally every 12 hours. Treatment duration is typically continued for 10 to 14 days.
  • Community-acquired pneumonia with concurrent bacteremia (CAP): The recommended dose of community-acquired pneumonia with concurrent bacteremia is 600 mg administered IV or orally every 12 hours. Treatment duration usually continues for 10 to 14 days.
  • Complicated skin and skin structure infections: In complicated skin and soft tissue infections (cSSTIs), the recommended linezolid dosage is 600 mg IV or orally every 12 hours. Treatment duration typically is 10 to 14 days.
  • Vancomycin-resistant Enterococcus faecium infections, including concurrent bacteremia: The recommended dose for vancomycin-resistant Enterococcus faecium infections, including concurrent bacteremia, is 600 mg administered IV or orally every 12 hours. Treatment duration is extended for a period of 14 to 28 days.
  • Uncomplicated skin and skin structure infections: Adults should take a recommended dose of 400 mg orally every 12 hours. Treatment duration typically is 10 to 14 days.

The most common side effects of Linezolid are decreased platelets, hemoglobin, white blood cell counts, elevated pancreatic enzymes, headache, nausea, diarrhea, elevated liver function tests, and neuropathy.

Warning and Precautions

  • Linezolid has been associated with myelosuppression (including anemia, leukopenia, pancytopenia, and thrombocytopenia). It is important to monitor complete blood counts weekly, especially in patients who have preexisting myelosuppression, are taking concomitant medications that may depress hemoglobin levels, platelet counts, or both, or who have a chronic infection and have been receiving Linezolid for more than 2 weeks.
  • Linezolid is a reversible, nonselective inhibitor of monoamine oxidase and can interact with serotonergic agents, potentially leading to serotonin syndrome. Symptoms include mental status changes, hyperthermia, autonomic instability, and neuromuscular abnormalities. Concomitant use with SSRIs, SNRIs, and other serotonergic agents should be avoided unless absolutely necessary.
  • Prolonged use of Linezolid (more than 28 days) has been associated with peripheral and optic neuropathy. Regular monitoring of vision is recommended for patients receiving Linezolid for extended periods.
  • Treatment with this medicine can cause hypoglycemia, particularly in diabetic patients on insulin or oral hypoglycemic agents. Blood glucose levels should be closely monitored in such patients during treatment.
  • There have been reports of lactic acidosis associated with the use of this medication. Symptoms include recurrent nausea and vomiting, unexplained acidosis, or a low bicarbonate level. Patients should be monitored for signs and symptoms of lactic acidosis during treatment.
  • Because Linezolid is a reversible MAO inhibitor, it can cause hypertension if taken with large quantities of tyramine-rich foods or sympathomimetic agents. Patients should be advised to avoid high-tyramine foods and drugs that can raise blood pressure.
  • As with other antibiotics, prolonged use of Linezolid may result in overgrowth of nonsusceptible organisms, including fungi. Regular assessment of the patient is essential to identify potential superinfections, and appropriate measures should be taken if a superinfection occurs.

FAQ's

What is Linospan?

Linospan is a brand name for Linezolid, an antibiotic used to treat serious bacterial infections, including those caused by multidrug-resistant Gram-positive bacteria.

How is Linezolid administered? 

Linezolid is administered orally or intravenously, typically every 12 hours, with or without food, as prescribed by a physician.

How can I store Linezolid?

Store Linezolid at room temperature, away from light and moisture, and keep it out of reach of children and pets.

How much does Linezolid cost in India?

The cost of Linezolid in India is reasonable and can vary. To procure this therapeutic drug legally, you can call us at (+91) 8130290915, TOLL-FREE: 1800-889-1064, Or Write us at info@indiangenericmedicines.com.

Can Linezolid be used while I’m pregnant?

Linezolid may be unsafe if used during pregnancy. Talk to your doctor about the best way to help control your disease if you want to become pregnant or during pregnancy. 

Can Linezolid be used while breastfeeding?

Breastfeeding is not recommended while on Linezolid. Talk to your doctor if you are breastfeeding or intend to breastfeed.

Where can I get Linezolid at the best Price? 

Order Linezolid at the best price today. We request you to Call/WhatsApp us at (+91) 8130290915 or dial our TOLL-FREE Number: 1800-889-1064 or Write us at info@indiangenericmedicines.com. We are fully committed to providing you with the best Linezolid price from India. That is why we’ll match the price of any other facilitators/suppliers/distributors in the market who require a medical prescription.

Is the Linezolid available in India?

Linezolid is a (prescription drug, doctor-prescribed medication, or health care professional-prescribed medicine) pharmaceutical drug that can be legally dispensed against a medical prescription. Linezolid can be made available through the network of authorized distributors in India. (Mumbai, Ahmedabad, Kolkata, Hyderabad, Bangalore, Chennai, Delhi, Pune, etc.). 

Can You Send the Linezolid to Foreign Destinations?

Buy generic Linezolid online at the best/lowest price from a leading supplier. Indian Generic Medicines (IGM) can assist in the delivery of Linezolid; the doctor-prescribed medication to the UK, Canada, UAE, Australia, Philippines, the USA, Saudi Arabia, Thailand, China, South Africa, Kazakhstan, Uzbekistan, Sri Lanka, Zambia, Pakistan, Kuwait, Sweden, Hong Kong, Turkey, Afghanistan, Malaysia, Singapore, Qatar, Japan, Nepal, and many other countries.

What is the procedure to buy Linezolid from Indian Generic Medicines? 

Patients can simply fill out the order form or send mail to info@indiangenericmedicines.com. Patients can also send WhatsApp messages to +91 8130290915 or dial the TOLL-FREE Number: 18008891064. We will reply ASAP with the details of the Linezolid price and the procurement procedure.

Note:- The order will be confirmed only after the valid receipt of the prescription from the Physician.

Is it safe to buy Linezolid online from India?

Yes, one can buy Linezolid online from India-based Indian Generic Medicines if this medicine is not (yet) registered or is unavailable in your respective country. We can facilitate the supply of Linezolid through legal channels.

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