Pentoxifylline

  • Medicine name- Kinetal
  • API- Pentoxifylline
  • Packaging- Tablets
  • Strength- 400mg 
  • Manufactured By: Cipla Ltd
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Description

Introduction to Pentoxifylline Tablets

Uses of Medicine: Pentoxifylline tablets 400 mg belongs to a group of medicines known as xanthine derivatives or hemorrheologic agents. Patients, Healthcare Professionals, or Hospitals can buy Pentoxifylline 400 mg Tablets online from India through Indian Generic Medicines (a trusted Pentoxifylline Supplier, Exporter, and Contract Manufacturer in India) for the management and treatment of:

  • Peripheral arterial disease (PAD)
  • Chronic venous insufficiency (CVI)
  • Vascular dementia
  • Sickle cell disease
  • Alcoholic hepatitis
  • Raynaud’s phenomenon
  • Impaired wound healing

Pentoxifylline 400 mg is designed to work by improving blood flow in the body. This is performed by reducing the thickness (viscosity) of the blood and making red blood cells (RBCs) more flexible. This drug is particularly used for treating a condition known as Peripheral Arterial Disease (PAD). In PAD, the blood flow to the limbs—usually the legs—is reduced because of narrowed arteries. This causes pain and cramping during walking or exercise, a symptom known as intermittent claudication. This therapeutic drug helps ease these signs and symptoms by improving circulation.

Apart from PAD, the Pentoxifylline 400 mg tablet is also effective in treating chronic venous insufficiency. This is a condition where blood does not flow appropriately back to the heart from the legs. This can be responsible for causing swelling, pain, or changes to the skin. The medicine also supports the healing of certain skin conditions developed due to poor blood flow. Improving the circulation helps the body repair tissues and relieve discomfort. Always take this medicinal product as directed by your healthcare provider (HCP), and do not change the dose without consulting a medical professional.

Some individuals should avoid taking Pentoxifylline 400 mg. If you are allergic to it or any ingredient in the tablet, just avoid it. Individuals with bleeding disorders, a known history of stroke, or recent major surgery should also not take this medicine. The medicine is not safe for individuals with recent bleeding in the brain or eyes. Before taking the tablet, let your doctor know in case you have kidney complications or if you are using therapeutic drugs that affect the kidneys or increase the risk of bleeding.

This medicinal product is not recommended for children. Its effects have not been completely studied in young patients. The elderly should use it under proper supervision, as they may require dose adjustments. It is important to follow your clinician’s instructions and inform them about all current medicinal products and health complications before starting treatment with Pentoxifylline 400 mg tablets.

Dosage & Side Effects

  • Regular Dosage:
    • Take one tablet of Pentoxifylline 400 mg 3 times a day with meals.
    • It’s best to keep taking it for at least 8 weeks to see its full effects.
    • The medicine usually starts working within 2 to 4 weeks.
  • Side Effects and Adjustments:
    • Some side effects might occur in the digestive or nervous system, especially if the dosage is high.
    • If these side effects show up, the dosage should be decreased to one tablet twice a day (800 mg/day).
    • If the side effects continue even with the lower dosage, stop taking Pentoxifylline.
  • Severe Renal Impairment:
    • For patients with severe kidney problems (creatinine clearance below 30 mL/min), the dose should be reduced to 400 mg once a day.
  • Hepatic Impairment:
    • There isn’t specific dosing information available for patients with liver problems, so it’s best to consult a healthcare professional in such cases.

The common side effects of Pentoxifylline tablet are Chest Pain, Abdominal Discomfort, Bloating, Diarrhea, Nausea, Vomiting, Headache, Dizziness, etc.

Warnings and Precautions

Warning – Contraindications:

  • Pentoxifylline should not be used if:
    • There has been recent bleeding in the brain or eyes.
    • There’s a history of intolerance or bad reactions to Kinetal tablet or similar substances like caffeine.

Precautions:

  • General:
    • Stop taking Kinetal tablet immediately if signs of a severe allergic reaction appear.
    • People with artery problems in their limbs might experience chest pain, low blood pressure, or irregular heartbeat while taking Kinetal tablet, though this is not common. It’s related to substances like caffeine.
    • Those taking Warfarin or with a risk of bleeding (due to recent surgery, ulcers, brain or eye bleeding) need more frequent checks for bleeding issues.
  • Specific Conditions:
    • In individuals with liver or kidney problems, the levels of Kinetal tablet in the body may increase. However, the consequences of this increase are not fully understood.

FAQ's

What is Pentoxifylline used for?

Pentoxifylline is used to improve blood flow in people with circulation problems due to conditions like peripheral artery disease (PAD). It helps by making blood flow more smoothly through the small blood vessels.

 How does Pentoxifylline work?

It works by making red blood cells more flexible, which helps them move easily through narrowed blood vessels. This improved blood flow can benefit individuals with circulation issues in their legs or arms.

What are the common side effects of Pentoxifylline?

Common side effects include nausea, vomiting, dizziness, headache, and upset stomach. In some cases, individuals might experience flushing, low blood pressure, or changes in heart rate.

Can Pentoxifylline be used by everyone with circulation problems?

Not necessarily. It’s important to consult a healthcare professional before starting Pentoxifylline, especially if you have specific health conditions, allergies, or if you’re taking other medications. Certain conditions or medications might interact with Pentoxifylline or increase the risk of side effects.

How should Pentoxifylline be taken?

The typical dosage of Pentoxifylline is usually prescribed by a doctor and is taken orally with meals. It’s commonly taken two or three times a day. It’s crucial to follow the prescribed dosage and not adjust it without consulting a healthcare provider.