Lenalidomide Capsules

  • Medicine Name- Lenalid
  • API- Lenalidomide
  • Packaging- Capsules
  • Strength- 5mg, 10mg, 15mg, 25mg
  • Manufactured by- Natco Pharma
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Description

Lenalidomide Capsules is an immunomodulatory oral medicine that is a more potent analog of thalidomide used for the treatment of adult patients with:

  • Multiple myeloma (MM), also known as Kahler’s disease, in combination with the therapeutic drug dexamethasone.
  • Multiple myeloma (MM), as maintenance therapy following autologous hematopoietic stem cell transplantation (auto-HSCT).
  • Transfusion-dependent anemia because of low- or intermediate-1-risk MDS associated with a deletion 5q abnormality with or without additional cytogenetic abnormalities.
  • Mantle cell lymphoma (MCL) whose disease has relapsed or progressed after 2 prior therapies, one of which included bortezomib.
  • Previously treated follicular lymphoma (FL), in combination with a medicinal product rituximab.
  • Previously treated marginal zone lymphoma (MZL), in combination with a medication rituximab.

Dosage and Side Effects

The recommended starting dose of Lenalidomide is taken orally at about the same time each day, either with or without food. Swallow the capsules whole with water and do not open, break, or chew them as per the following dosage regimen:

  • MM combination therapy: Lenalidomide 25 mg once daily administered orally on Days 1 to 21 of repeated 28-day cycles.
  • MM maintenance therapy following auto-HSCT: Lenalidomide 10 mg once daily administered continuously on Days 1 to 28 of repeated 28-day cycles.
  • MDS: Lenalidomide 10 mg once daily.
  • MCL: Lenalidomide 25 mg once daily administered orally on Days 1-21 of repeated 28-day cycles.
  • FL or MZL: Lenalidomide 20 mg once daily administered orally on Days 1-21 of repeated 28-day cycles for up to 12 cycles.

The most common side effects of Lenalidomide capsules in patients with Multiple myeloma (MM), MDS, and Non-Hodgkin’s Lymphoma (NHL: MCL, FL or MZL) are as follows:

  • MM: diarrhea, anemia, fatigue, constipation, leukopenia, neutropenia, peripheral edema, back pain, insomnia, muscle cramp/spasms, abdominal pain, nausea, asthenia, pyrexia, cough, upper respiratory tract infection, nasopharyngitis, bronchitis, gastroenteritis, rash, dyspnea, dizziness, thrombocytopenia, decreased appetite, and tremor.
  • MDS: thrombocytopenia, dizziness, headache, neutropenia, pruritus, rash, fatigue, constipation, diarrhea, nausea, nasopharyngitis, arthralgia, pyrexia, back pain, pharyngitis, peripheral edema, muscle cramp, cough, dyspnea, and epistaxis.
  • Non-Hodgkin’s Lymphoma (NHL: MCL, FL or MZL): nausea, neutropenia, rash, diarrhea, fatigue, thrombocytopenia, anemia, constipation, leukopenia, pyrexia, cough, and upper respiratory tract infection.

Warning and Precautions

  • Lenalidomide oral drug can result in neutropenia and thrombocytopenia. Monitor patients with neutropenia for symptoms of infection. Observe them for bleeding or bruising, mainly with the use of concomitant drugs that may increase the probability of bleeding. Assess complete blood counts (CBC) periodically.
  • Venous thromboembolic events (VTE [PR and DVT]) and arterial thromboembolic events (ATE, myocardial infarction, and stroke) are increased in those treated with Lenalidomide capsules.  
  • Hepatic failure, including fatal cases, may occur in patients treated with Lenalidomide together with dexamethasone. Monitor liver enzymes periodically. Stop treatment upon elevation of liver enzymes. After the return to baseline values, treatment at a reduced dose may be considered. 
  • Angioedema and severe cutaneous reactions including TEN, Stevens-Johnson syndrome (SJS), and drug reactions with eosinophilia and systemic symptoms (DRESS) may occur. DRESS may present with a cutaneous reaction (such as exfoliative dermatitis or rash), fever, eosinophilia, or lymphadenopathy with systemic complications such as nephritis, myocarditis, pneumonitis, hepatitis, and/or pericarditis.
  • Fatal cases of tumor lysis syndrome (TLS) may occur during therapy with Lenalidomide 5 mg, 10 mg, 15 mg, and 25 mg capsules. The patients at probability of TLS are those with higher tumor burden before treatment. Monitor patients at risk precisely and consider suitable preventive approaches.
  • Tumor flare reaction (TFR) may occur during the use of Lenalidomide for CLL and lymphoma and is characterized by tender lymph node swelling, pain, low-grade fever, and rash. This drug is not for use in CLL outside of controlled clinical trials. Monitoring and assessment for TFR is required in those with MCL, FL, or MZL. TFR may mimic the progression of disease (PD).

FAQ's

What is Lenalidomide?

Lenalidomide is sold under the generic brand name Lenalid, which belongs to a group of drugs known as immunomodulatory drugs (IMiD). It is used for the treatment of multiple myeloma (MM), myelodysplastic syndromes (MDS), mantle cell lymphoma (MCL), and marginal zone lymphoma (MZL).

How do I take Lenalidomide

Lenalidomide is available as capsules that you take with a glass of water. Swallow the capsules whole without opening, breaking, or chewing.

How to store Lenalidomide?

Store the capsules of Lenalidomide at 20-25°C (68-77°F); excursions permitted to 15-30°C (59-86°F).

How much does Lenalidomide cost in India?

Lenalidomide cost in India is very reasonable and can vary. To procure this medicine legally, you can call us at (+91) 8130290915, TOLL-FREE: 1800-889-1064, Or Write us at info@indiangenericmedicines.com.

Can Lenalidomide be used while I’m pregnant?

Lenalidomide is a thalidomide analogue and is unsafe for use during pregnancy. Talk to your healthcare provider about the finest way to help control your condition if you want to become pregnant or during pregnancy. 

Where can I get Lenalidomide at the best Price? 

Order Lenalidomide at the best price today. We request you to Call/WhatsApp us at (+91) 8130290915 or dial our TOLL-FREE: 1800-889-1064 or Write us at info@indiangenericmedicines.com. We’re committed to providing you with the best lenalidomide price from India. That is why we’ll match the cost/price of any other existing facilitators/suppliers/distributors in the market who require a medical prescription.

Is Lenalidomide available in India?

Lenalidomide is a (prescription drug, doctor-prescribed medicine, or health care professional-prescribed medication) pharmaceutical drug that can be legally dispensed against a medical prescription. Capsules of Lenalidomide can be made available through the network of authorized distributors in India. (Kolkata, Mumbai, Bangalore, Ahmedabad, Hyderabad, Chennai, Delhi, Pune, etc.)

Can You Send Lenalidomide to Foreign Destinations?

Buy generic lenalidomide online at the lowest price from a leading supplier. Indian Generic Medicines (IGM) can assist in the delivery of Lenalidomide; the doctor-prescribed medication to the UK, Canada, Philippines, Australia, Kazakhstan, the USA, Saudi Arabia, Thailand, China, South Africa, Uzbekistan, Sri Lanka, Afghanistan, Zambia, Pakistan, Malaysia, Kuwait, Sweden, Hong Kong, UAE, Turkey, Singapore, Nepal, Qatar, Japan, and many other countries.

What is the procedure to buy Lenalidomide from Indian Generic Medicines

Patients can fill out the order form or send mail to info@indiangenericmedicines.com. Patients can also send WhatsApp messages to +91 8130290915 or can dial the TOLL-FREE: 18008891064. We will reply ASAP with the details of the lenalidomide 5 mg/10 mg/15 mg/25 mg price and procurement process.

Note:- The order will be confirmed only after the valid receipt of the prescription from the Physician.

Is it safe to buy Lenalidomide (Lenalid) online from India?

Yes, one can buy Lenalidomide (Lenalid) online from India-based Indian Generic Medicines (IGM) if it is not (yet) registered or is unavailable in their respective country. We can help facilitate the supply/export of Lenalidomide capsules through legal channels.