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Nirmatrelvir + Ritonavir

  • Medicine Name – Paxlovid 
  • API – Nirmatrelvir+Ritonavir
  • Packaging – Tablet 
  • Strength – Nirmatrelvir 150 mg & Ritonavir 100 mg
  • Manufactured by – Pfizer Labs
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Description

PAXLOVID, a treatment comprising Nirmatrelvir + Ritonavir tablet , serves as a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (Mpro) inhibitor and an HIV-1 protease and CYP3A inhibitor. It’s intended for adults with mild-to-moderate COVID-19 at high risk for severe progression, excluding pre/post-exposure prophylaxis for COVID-19 prevention.

Dosage and Side Effects

PAXLOVID consists of nirmatrelvir ritonavir tablets co-administered orally, starting within 5 days of COVID-19 diagnosis. The standard dosage involves 300 mg nirmatrelvir (two 150 mg tablets) with 100 mg ritonavir (one 100 mg tablet) taken together twice daily for 5 days, to be initiated soon after symptom onset. Adjustments are suggested for moderate renal impairment, while severe renal or hepatic impairment requires caution.

The most common adverse reactions observed include dysgeusia and diarrhea.

Warning and Precautions

  • Potential significant drug interactions may occur when PAXLOVID is used with certain other medications. Review the Full Prescribing Information for possible drug interactions before and during treatment.
  • Hypersensitivity Reactions: Immediate discontinuation of PAXLOVID is advised if signs of a clinically significant hypersensitivity reaction or anaphylaxis emerge. Seek immediate medical attention and appropriate care if serious skin reactions occur.
  • Hepatotoxicity: Patients receiving ritonavir, one of the components of PAXLOVID, have experienced elevations in liver enzymes, clinical hepatitis, and jaundice. Monitor liver function tests during treatment.
  • HIV-1 Drug Resistance: PAXLOVID use may lead to the development of resistance to HIV-1 protease inhibitors in individuals with uncontrolled or undiagnosed HIV-1 infection 
  • Avoid PAXLOVID if there’s a history of clinically significant hypersensitivity reactions to its active ingredients (nirmatrelvir or ritonavir) or any other components.
  • Refrain from co-administering PAXLOVID with drugs highly dependent on CYP3A for clearance, as well as potent CYP3A inducers, to prevent potential serious reactions.

FAQ's

What is PAXLOVID used for?

PAXLOVID is for treating mild-to-moderate COVID-19 in high-risk adults to prevent severe progression.

How should PAXLOVID be taken?

It’s taken orally as 300 mg nirmatrelvir with 100 mg ritonavir, twice daily for 5 days, initiated within 5 days of symptom onset.

Are there any restrictions or precautions while using PAXLOVID?

Avoid PAXLOVID if there’s a history of significant hypersensitivity reactions or co-administration with certain drugs.

What are the common side effects of PAXLOVID?

Dysgeusia (distorted taste) and diarrhea are the most frequently observed adverse reactions.

Is PAXLOVID suitable for everyone with COVID-19 symptoms?

PAXLOVID is specifically recommended for adults at high risk for severe COVID-19 progression and should be initiated within 5 days of symptom onset.

What is the price of Paxlovid?

Price of Paxlovid is reasonable and one can readily purchase this medicine from a certified pharmaceutical supplier.

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