Methylprednisolone Injection

  • Medicine name- Mypred
  • API- Methylprednisolone Sodium Succinate
  • Pack Size- single-dose vial 
  • Strength- 500 mg, 1000 mg, 40 mg & 125 mg
  • Marketed By: Samarth Life Sciences Pvt Ltd
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Methylprednisolone injection is used for the treatment of any condition in which rapid and intense corticosteroid effect is needed such as:

Dermatological Disease:

  • Severe erythema multiforme (Stevens Johnson syndrome)

Allergic States:

  • Bronchial asthma
  • Severe seasonal and perennial allergic rhinitis
  • Angioneurotic oedema
  • Anaphylaxis

Gastrointestinal Diseases:

  • Ulcerative colitis
  • Crohn’s disease

Respiratory Diseases:

  • Aspiration of gastric contents
  • Fulminating or disseminated TB (Tuberculosis) (with apt antituberculous chemotherapy)

Neurological Disorders:

  • Cerebral oedema secondary to cerebral tumour
  • Acute exacerbations of the multiple sclerosis superimposed on a relapsing or remitting background.


  • T.B. meningitis (with appropriate antituberculous chemotherapy)
  • Transplantation

Dosage and Side Effects

The recommended initial dose for adult patients is usually 10-500 mg depending on the disease treated. Larger doses of methylprednisolone injection may be required for short-term management of severe, acute conditions. The initial dose, up to 250 mg, should be administered intravenously as a bolus injection over a period of at least 5 minutes, doses exceeding 250 mg should be administered as an infusion over a period of at least 30 minutes.

Elderly: Elderly will normally receive the same treatment as younger adults although the health specialist may decide to check the adverse events of treatment more closely.

Use in children: In infancy, childhood and adolescence, corticosteroids may be responsible for causing growth to be slowed down. This may be irreversible. A healthcare specialist should limit treatment to the minimum dose for the shortest period of time.

The most commonly reported side effects due to methylprednisolone injection include: headache, dizziness, nausea, sweating, and swelling in the hands or ankles (edema).

Warning and Precautions

  • Exposure to measles needs to be avoided. Medical advice should be sought promptly in case exposure occurs. Prophylaxis with normal intramuscular immunoglobulin may be required.

  • Do not give live vaccines to individuals with impaired immune responsiveness. The antibody response to certain other existing vaccines may be diminished.

  • If methylprednisolone 1000 mg (corticosteroids) are prescribed in patients with latent tuberculosis or tuberculin reactivity, precise observation is needed as reactivation of the disease may occur. While on prolonged corticosteroid therapy, these patients should receive chemoprophylaxis.

  • Nonsteroidal anti-inflammatory agents and aspirin should be used cautiously in conjunction with methylprednisolone iv therapy.

  • Methylprednisolone should be used with caution in those patients who are with seizure disorders. Frequent patient monitoring is recommended in patients with epilepsy.

  • Methylprednisolone should be used with caution in those patients who are with myasthenia gravis. Frequent patient monitoring is recommended in patients with myasthenia gravis.

  • During treatment with methylprednisolone iv, frequent patient monitoring is recommended in those patients who are with glaucoma (or a family history of glaucoma) and in patients with ocular herpes simplex, for fear of corneal perforation.

  • Use methylprednisolone cautiously in patients with hypertension. Frequent patient monitoring is recommended.


What is Methylprednisolone?

Methylprednisolone contains Methylprednisolone Sodium Succinate and belongs to a group of medicines named corticosteroids (steroids). Corticosteroids are produced naturally in the body and are crucial for many body functions. Boosting the body with extra corticosteroids such as methylprednisolone 1000 mg can help with surgery (e.g. organ transplants), flare-ups of the signs and symptoms of multiple sclerosis or other stressful conditions.

What dosage strengths Methylprednisolone injection is supplied?

Methylprednisolone is supplied as Powder for solution for injection in the following dosage strength which are:

  • Methylprednisolone 40 mg
  • Methylprednisolone 125 mg
  • Methylprednisolone 250 mg
  • Methylprednisolone 500 mg
  • Methylprednisolone 1000 mg 

How is Methylprednisolone administered?

Methylprednisolone powder for injection/infusion is administered intravenously or intramuscularly. 

What type of medicine is Methylprednisolone?

Methylprednisolone specifically is a type of medicine called corticosteroids (steroids).

Where can I buy Methylprednisolone?  

You can buy Methylprednisolone from any authorized whole-seller after getting a prescription from a qualified doctor. It is always better to check the credential of the whole-seller/supplier/exporter before buying the product.

The buyer should check the existing law in their home country before importing the product.