• Medicine Named : LediHep
  • API : Sofosbuvir+Ledipasvir
  • Strength : 400mg+90mg
  • Pack Size: 28 tablets strip
  • Company Name: Zydus Cadila
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LediHep Tablet treats chronic hepatitis C in adults and kids 3 years and older with:

  • Genotypes 1, 4, 5, or 6 infection without serious liver damage or with manageable liver damage.
  • Genotype 1 infection with serious liver damage, when used with ribavirin.
  • Genotype 1 or 4 infection in people who have had a liver transplant without serious liver damage or with manageable liver damage, also when used with ribavirin.

Dosage and Side Effects

  • Before starting LediHep, you’ll be tested for another virus called HBV.
  • Treatment duration depends on liver condition:
    • Minimal liver damage: 12 weeks of LediHep.
    • More damage: 24 weeks or LediHep plus ribavirin for 12 weeks.
  • How to take LediHep: One tablet daily for adults, dosage varies by weight for kids.
  • Special cases, like HIV co-infection, require adjusted dosages.
  • LediHep comes in tablets or oral pellets with different strengths.
  • People with severe kidney issues might need different treatment.

The most common adverse reactions observed with treatment with LediHep were fatigue, headache, and asthenia

Warning and Precautions

  • To minimize the risk of Hepatitis B Virus reactivation, it’s essential to test all patients for any current or past HBV infection before starting treatment for HCV. For those with both HCV and HBV, careful monitoring for HBV reactivation and potential liver flare-ups during and after HCV treatment is crucial. Patients showing signs of HBV infection should receive appropriate medical attention.
  • Regarding bradycardia when taking amiodarone alongside LediHep: There’s a serious risk of slow heartbeat, especially in patients also on beta blockers, or with existing heart or liver issues. Using amiodarone with LediHep isn’t recommended. If no other treatment options exist, cardiac monitoring becomes necessary.


What is LediHep and What Does It Treat?

LediHep is a medication used to treat chronic hepatitis C virus (HCV) infection in adults and children. It’s a combination of ledipasvir, an HCV NS5A inhibitor, and sofosbuvir, an HCV nucleotide analog NS5B polymerase inhibitor.

How Does LediHep Work?

LediHep works by targeting different parts of the hepatitis C virus, preventing it from multiplying and reducing its presence in the body. This helps the immune system clear the virus.

What Are the Recommended Dosage and Duration of LediHep?

The dosage and duration depend on various factors, such as the patient’s prior treatment history and the severity of liver damage. Typically, it’s taken orally once a day, but specific dosing varies based on individual circumstances.

Are There Any Special Precautions or Considerations When Taking LediHep?

Patients should discuss their medical history, especially concerning heart conditions or prior hepatitis B infections, as well as any medications they’re currently taking, to avoid potential complications or drug interactions.

What Side Effects Can Occur with LediHep?

Common side effects of LediHep may include headache, fatigue, nausea, and trouble sleeping. However, individual responses can vary, so patients should promptly report any unusual symptoms to their healthcare provider.